Effects of sinomenine in LPS‐associated diseases are related to inhibition of LBP, Mac‐1, and L‐selectin levels

Abstract

The aim of the research was to investigate the anti‐endotoxin and anti‐inflammatory effects of Sinomenine, an agent commonly found in Chinese herbal medicines. Endotoxin (i.e., 1 mg lipopolysaccharide (LPS)/kg)) was administered via intraperitoneal (IP) injection to piglets in high‐, middle‐, and low‐dose sinomenine groups. Piglets were then treated with 1, 5 or 10 mg/kg sinomenine, intramuscularly (i.m.), 3 hr after LPS. Vehicle was administered, as above, to drug control group piglets followed 3 hr later by 10 mg/kg sinomenine i.m.. LPS control group piglets were challenged with 1 mg/kg LPS IP, followed by vehicle i.m., and naïve control piglets were treated with normal saline IP, followed by normal saline i.m., as above. Temperatures were measured, and blood samples were collected from the precaval veins of piglets at 12, 24, and 48 hr post‐LPS or vehicle injection. Clinical signs were recorded, and index levels were analyzed via ELISA. Sinomenine was found to reduce the incidence and severity of LPS‐induced toxicities, including body temperature elevation, cell adhesion, and systemic inflammation. These data suggest that sinomenine may be effective for regulating inflammatory responses and has the potential for use as an anti‐endotoxin therapy.

Potential Therapeutic Applications of Plant-Derived Alkaloids against Inflammatory and Neurodegenerative Diseases

“…Sinomenine. Sinomenine is a kind of benzyl alkaloid commonly found in Chinese herbal medicine that is mainly isolated from the root and stem of Sinomenium acutum [108]. It has a therapeutic application in treating chronic nephritis, rheumatoid arthritis, myocardial ischemia, ankylosing spondylitis, and other rapid arrhythmias and reduces associated foot swelling caused by formaldehyde, egg white, or carrageenan [109].…”

Research Progress on Anti‐Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs

“…et Wils. [28]. It can be used in the treatment of rheumatoid arthritis, chronic nephritis, ankylosing spondylitis, myocardial ischemia, ventricular premature beats, and other rapid arrhythmias.…”

Sinomenine Inhibits the Progression of Bladder Cancer Cells by Downregulating LncRNA-HEIH Expression

“…Sinomenine is a monomer alkaloid component extracted from Caulis Sinomenii, which belongs to isoquinoline alkaloid. Sinomenine has anti-inflammatory, antirheumatism, antitumor, sedation, antihypertensive, antiarrhythmia, immunosuppression, and other pharmacological effects [9][10][11]. Numerous experiments have shown that sinomenine can inhibit the development of breast cancer, stomach cancer, lung cancer, and ovarian cancer [12][13][14].…”