Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

Abstract

Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as a biomedical material was investigated. The results indicated that the densification and crystallinity of MP increased as the sintering temperature increased. As the sintering temperature increased, the degradability of MP in PBS decreased, and the mineralization ability in SBF significantly increased. In addition, the MP sintered at 800 °C (MP8) possessed the lowest degradability and highest mineralization ability. Moreover, the positive response of MG63 cells to MP significantly increased as the sintering temperature increased, and MP8 significantly promoted the cell spreading, proliferation, differentiation and expressions of osteogenic differentiation-related genes. Faster degradation of MP0 resulted in higher pH environments and ion concentrations, which led to negative responses to osteoblasts. However, the appropriate degradation of MP8 resulted in suitable pH environments and ion concentrations, which led to positive responses to osteoblasts. This study demonstrated that the sintering temperature substantially affected the surface morphology/microstructure, degradability and mineralization, and osteoblasts response to magnesium phosphate.

Osteoconductive Effect of a Nanocomposite Membrane Treated with UV Radiation

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“…and C-O stretching vibrations, respectively. Additionally, the absorption band at 1399 cm −1 ascribed to the C-F stretching vibration of DEX [28] is also clearly observed (Fig. 4c).…”

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“…By inducing the formation of apatite on the surface of a biomaterial in contact with relevant biological fluids like SBF, it becomes possible to gain deeper understating of its in vitro bioactivity and its potential to promote bone regeneration or establish interfacial bonding with bone tissue in-vivo [25]. The process of bone growth, where calcium and phosphate are deposited on the bone matrix, plays a crucial role in determining the bone ability to form and develop.…”