Effects of sleep deprivation on cognitive functions

Zhang, Na; Liu, Hongtao

doi:10.1007/s12264-008-0910-z

Cited by 15 publications

(6 citation statements)

References 29 publications

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“…Thus, the indirect excitatory effect of orexin might offset the inhibitory action of adenosine on orexin neurons and consequently reverse the sleeppromoting effect of adenosine. The modulation of orexin neurons plays an important role in regulating sleep and wakefulness, especially under prolonged wakefulness in which sleep pressure is enhanced rapidly due to the large release of endogenous adenosine [35] . Caffeine, a nonselective adenosine receptor antagonist, is a widely used stimulant that effectively reverses the depressant effects of increasing sleep propensity [36] , although the sideeffect of drug-dependence has restricted its therapeutic use as an arousal-promoting agent [37] .…”

Section: Discussionmentioning

confidence: 99%

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats

et al. 2014

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Orexin neurons within the lateral hypothalamus play a crucial role in the promotion and maintenance of arousal. Studies have strongly suggested that orexin neurons are an important target in endogenous adenosine-regulated sleep homeostasis. Orexin A induces a robust increase in the firing activity of orexin neurons, while adenosine has an inhibitory effect. Whether the excitatory action of orexins in the lateral hypothalamus actually promotes wakefulness and reverses the sleep-producing effect of adenosine in vivo is less clear. In this study, electroencephalographic and electromyographic recordings were used to investigate the effects of orexin A and adenosine on sleep and wakefulness in rats. We found that microinjection of orexin A into the lateral hypothalamus increased wakefulness with a concomitant reduction of sleep during the first 3 h of post-injection recording, and this was completely blocked by a selective antagonist for orexin receptor 1, SB 334867. The enhancement of wakefulness also occurred after application of the excitatory neurotransmitter glutamate in the fi rst 3 h post-injection. However, in the presence of the NMDA receptor antagonist APV, orexin A did not induce any change of sleep and wakefulness in the first 3 h. Further, exogenous application of adenosine into the lateral hypothalamus induced a marked increase of sleep in the fi rst 3-h post-injection. No signifi cant change in sleep and wakefulness was detected after adenosine application followed by orexin A administration into the same brain area. These findings suggest that the sleep-promoting action of adenosine can be reversed by orexin A applied to the lateral hypothalamus, perhaps by exciting glutamatergic input to orexin neurons via the action of orexin receptor 1.

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Section: Discussionmentioning

confidence: 99%

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats

et al. 2014

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“…However, it is necessary to consider the effect that sleep loss has on cognitive performance and mood. It is well established that sleep loss degrades cognitive performance [57]. Previous studies in military populations have consistently shown impairments in vigilance, reaction time and working memory [58,59].…”

Section: Additional Considerationsmentioning

confidence: 99%

The Effects of Sleep Loss on Military Physical Performance

et al. 2019

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Sleep loss appears to negatively affect aerobic capacity, upper body anaerobic capacity, muscular endurance and military task performance. Confounding factors such as motivation and nutrition may negate the negative effects of sleep loss on physical domains (e.g. lower body strength and aerobic capacity, respectively). Because the exact relationship between sleep loss and physical performance in military populations remains unclear, applicable practical recommendations cannot be provided.

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“…Sleep plays a key role in human life and work, but sleep deprivation (SD), namely irregular and inadequate sleep, shows a rising trend in today’s society (Feng et al, 2016; Honn et al, 2018). Therefore, the association between SD and cognitive impairment has been paid close attention (Zhang and Liu, 2008; Jin et al, 2017; Li S. et al, 2017). It is well known that SD affects human health and work efficiency (Honn et al, 2018) and that SD is a common state leading to a global cognitive decline for individuals (Jackson et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Inhibited Endogenous H2S Generation and Excessive Autophagy in Hippocampus Contribute to Sleep Deprivation-Induced Cognitive Impairment

et al. 2019

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Background and Aim: Sleep deprivation (SD) causes deficit of cognition, but the mechanisms remain to be fully established. Hydrogen sulfide (H2S) plays an important role in the formation of cognition, while excessive and prolonged autophagy in hippocampus triggers cognitive disorder. In this work, we proposed that disturbances in hippocampal endogenous H2S generation and autophagy might be involved in SD-induced cognitive impairment.Methods: After treatment of adult male wistar rats with 72-h SD, the Y-maze test, object location test (OLT), novel object recognition test (NORT) and the Morris water maze (MWM) test were performed to determine the cognitive function. The autophagosome formation was observed with electron microscope. Generation of endogenous H2S in the hippocampus of rats was detected using unisense H2S microsensor method. The expressions of cystathionine-β-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MST), beclin-1, light chain LC3 II/LC3 I, and p62 in the hippocampus were assessed by western blotting.Results: The Y-maze, OLT, NORT, and MWM test demonstrated that SD-exposed rats exhibited cognitive dysfunction. SD triggered the elevation of hippocampal autophagy as evidenced by enhancement of autophagosome, up-regulations of beclin-1 and LC3 II/LC3 I, and down-regulation of p62. Meanwhile, the generation of endogenous H2S and the expressions of CBS and 3-MST (H2S producing enzyme) in the hippocampus of SD-treated rats were reduced.Conclusion: These results suggested that inhibition of endogenous H2S generation and excessiveness of autophagy in hippocampus are involved in SD-induced cognitive impairment.

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Effects of sleep deprivation on cognitive functions

Cited by 15 publications

References 29 publications

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats

Orexin A attenuates the sleep-promoting effect of adenosine in the lateral hypothalamus of rats

The Effects of Sleep Loss on Military Physical Performance

Inhibited Endogenous H2S Generation and Excessive Autophagy in Hippocampus Contribute to Sleep Deprivation-Induced Cognitive Impairment

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