Effects of Smoking and HLA-B51 on Clinical Manifestations in Behçet’s Disease: Retrospective Analysis of 209 Patients in a Turkish Population

Abstract

Objectives: This study aims to investigate the separate and cumulative effects of smoking and human leukocyte antigen (HLA)-B51 on the severity and clinical manifestations of Behçet's disease (BD). Patients and methods: A total of 209 patients (119 males, 90 females; mean age 42.97±10.44 years; range 23 to 75 years) with BD were included in this retrospective study. The severity and clinical manifestations of BD, smoking habits, and presence of HLA-B51 of patients were obtained from medical records. The severity of BD was evaluated with Behçet's Syndrome Activity Scale (BSAS). Relationship between smoking habits and presence of HLA-B51 with disease severity and clinical manifestations was investigated. Results: Presence of HLA-B51 was effective on BSAS, erythema nodosum (EN), articular, ocular and neurological involvements (p=0.001, p=0.011, p=0.013, p=0.001, p=0.038, respectively). Smoking was also effective on BSAS, EN, articular, ocular and neurological involvements (p=0.001, p=0.001, p=0.013, p=0.042, p=0.027, respectively). There was a strong association between positive HLA-B51 with smoking (p=0.004). Smoking and HLA-B51 were effective on articular involvement, smoking was effective on EN, and HLA-B51 and smoking were effective on ocular and neurological involvements (p=0. 039, p=0.040, p=0.001, p=0.028, p=0.037, respectively). Conclusion: Our findings indicate that smoking and HLA-B51 influence severity and systemic involvements of BD with a positive relationship in between. We recommend that smoking and HLA-B51 should be considered simultaneously in BD since this relationship may lead to incorrect inferences.

SAT0681 The causal association between childhood and adulthood body mass index and osteoarthritis: a mendelian randomizationstudy

“…Lund 3 , T. M. Aaløkken 4 , P. Szodoray 5 , E. Bodolay 6 . 1 Rheumatology, Oslo University Hospital, Oslo, Norway; 2 Rheumatology, Mayo Foundation for Medical Education and Research, Rochester, USA; 3 Respiratory Medicine; 4 Radiology, Oslo University Hospital; 5 Centre for Immune Regulation, University of Oslo, Oslo, Norway; 6 Clinical Immunology, University of Debrecen, Debrecen, Hungary Background: Mixed Connective Tissue Disease (MCTD) is characterised by the presence of anti-RNP antibodies with clinical features also found in SSc, SLE and IIM. There is an ongoing debate of MCTD's position as a CTD.…”

Frequency of HLA-B51 in Behçet's Patients and Relationship with Clinical Findings

“…6 In our study, oral aphthous ulceration (100%) was the most common symptom of the patients similarly to previous studies. 18,[21][22][23] In their study, Müftüoğlu et al found no positive or negative association betwe en HLA-B5 and age at onset, gender, ocular involvement, arthritis, thrombophlebitis and erythema nodosum. 24 In another study conducted in Turkey including 406 patients HLA-B51 was positive in 170 patients out of 372 (45.7%).…”

SAT0679 Cigarette smoking and risk of behcet’s disease: a case-control study

“…Although few studies reported association between smoking and clinical manifestations of BD, to the best of our knowledge, there is no research on the risk of developing BD in smokers. [2][3][4] This case-control study was conducted to investigate the association between smoking and the risk of BD. Methods: We included 192 patients with BD and 822 healthy siblings of patient with BD and 373 age and sex matched healthy unrelated persons as control groups (table 1).…”