Effects of Smoking, Depression, and Anxiety on Mortality in COPD Patients: A Prospective Study

Lou, Peian; Chen, Peipei; Zhang, Pan; Yu, Junhong; Wang, Yong; Chen, Na; Zhang, Lei; Wu, Hongmin; Zhao, Jing

doi:10.4187/respcare.02487

Cited by 34 publications

(32 citation statements)

References 43 publications

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“…[44][45][46] Depressed patients also have lower self-confidence, greater feelings of hopelessness, and increased apathy. 6,47 Depression contributes to suboptimal disease control due to poor self-care and lack of motivation to seek help, resulting in nonadherence to medication, 48 less likelihood of quitting smoking, 49,50 and poor participation in pulmonary rehabilitation, 51 leading to ineffective COPD management.…”

Section: Discussionmentioning

confidence: 99%

Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD

Singh

Zhang

Kuo

et al. 2016

Chest

100

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Section: Discussionmentioning

confidence: 99%

Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD

Singh

Zhang

Kuo

et al. 2016

Chest

100

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“…Furthermore a one-year prospective study reported baseline depression was associated with persistent smoking, longer hospitalization stay, increased symptom burden, poorer physical and social functioning, and increased mortality [22]. Lou and co-workers [24] in a prospective study (n = 7,787) investigated the impact of current smoking, depression on mortality in patients with COPD. Their findings indicated that patients who were current smokers with depressive symptoms were at four folds increase the risk of death.…”

Section: Impact Of Depression On the Course Of Copdmentioning

confidence: 99%

Pharmacological Treatment of Depression in Older Patients with Chronic Obstructive Pulmonary Disease: Impact on the Course of the Disease and Health Outcomes

Yohannes

Alexopoulos

2014

Drugs Aging

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Over 40% older chronic obstructive pulmonary disease (COPD) patients suffer from clinically significant depressive symptoms that may interfere in their daily activities. Untreated depression may increase physical disability, social isolation, hopelessness and healthcare utilization. This review examined the impact of depression on the course of COPD, and the efficacy of antidepressant drugs therapy and their implication for clinical practice. The efficacy of antidepressants from the published trials in patients with COPD has been inconclusive. Specifically, there has been no clear evidence that antidepressants can induce remission of depression or ameliorate dyspnoea or physiological indices of COPD. Both the selective reuptake inhibitors (SSRI) and tricycle antidepressant (TCA) studies conducted in depressed COPD patients have been significantly limited by methodological weaknesses including low sample size, sample heterogeneity, and variability in scales used to diagnose and to monitor the treatment of depression. For this reason, it remains unclear whether which SSRIs or TCAs should be favoured in the treatment of depressed COPD patients and what is an appropriate dosage and duration range. Simply offering antidepressant drugs to older depressed COPD patients is unlikely to improve their conditions. Promising treatment strategies such as cognitive behavioural therapy and collaborative care approach should be considered with or without antidepressants drug therapy for depressed COPD patients. Further studies are needed with large randomised controlled trials to examine the efficacy of antidepressants in patients with COPD with long-term follow-up.

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“…Depression also increases severity of COPD due to its effect on early addictive smoking and impediment of smoking cessation 7 . In addition, non COPD-related outcomes of depression include longer hospitalization 8 , mortality 9 , impaired functional status, poor exercise capacity 8 , poor quality of life 10 , non-adherence to medical treatment, and sleep disturbances 8 .…”

Section: Introductionmentioning

confidence: 99%

Depression treatment patterns among adults with chronic obstructive pulmonary disease and depression

Deb

Sambamoorthi

2016

Current Medical Research and Opinion

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Objective To estimate rates and the patterns of depression treatment among adults with Chronic Obstructive Pulmonary Disease (COPD) and depression. Methods We used a retrospective, cross-sectional study design, pooling data from 2010 and 2012 Medical Expenditure Panel Survey (MEPS). The study sample consisted of 527 individuals aged 21 years or older, diagnosed with COPD and depression. Depression treatment was grouped into 3 categories based on those who received: 1) neither antidepressant nor psychotherapy; 2) antidepressants only; and 3) psychotherapy combined with antidepressants (combination therapy). We conducted chi-squared tests and multinomial logistic regressions to examine factors (demographic, socio-economic characteristics, healthcare access, health status, and personal health practices) associated with depression treatment among adults with COPD and depression. Key Findings The mean age of the study sample was 55.96 years(SD=13.36). Overall, 18.8% of the sample adults did not report any use of antidepressants or psychotherapy, 58.3% reported antidepressants use only and 23% reported using combination therapy. Females(AOR=1.89, 95% CI= 1.02, 3.55), older adults(>=65 years: AOR=3.69, 95% CI= 1.62, 8.41), adults with fair/poor physical health status(AOR=3.32, 95% CI=1.29, 8.56) and those suffering from anxiety (AOR=1.94, 95% CI= 1.09, 3.46) were more likely to receive antidepressant treatment. Older adults(AOR=2.94, 95% CI=1.05, 8.22), those who were never married(AOR=3.17, 95% CI=1.18, 8.56), suffered from anxiety(AOR=6.01, 95% CI=3.11, 11.61) and current smokers (AOR=2.29, 95% CI= 1.05, 4.98) were more likely to receive combination therapy. Whereas, adults who were uninsured(AOR=0.21, 95% CI= 0.05, 0.86) and did not have physical activity (AOR=0.33, 95% CI= 0.16, 0.67) were less likely to receive combination therapy. Key limitations of our study is that we could not control for the severity of depression or COPD which may have influenced depression treatment. Conclusion Efforts to improve depression care among adults with co-occurring COPD and depression may need to be tailored for different subgroups.

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Effects of Smoking, Depression, and Anxiety on Mortality in COPD Patients: A Prospective Study

Cited by 34 publications

References 43 publications

Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD

Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD

Pharmacological Treatment of Depression in Older Patients with Chronic Obstructive Pulmonary Disease: Impact on the Course of the Disease and Health Outcomes

Depression treatment patterns among adults with chronic obstructive pulmonary disease and depression

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