Effects of Smoking Exposure in Infants on Gastroesophageal Reflux as a Function of the Sleep–Wakefulness State

Djeddi, D.; Stéphan-Blanchard, Erwan; Léké, A.; Ammari, Mohamed; Delanaud, Stéphane; Lemaire-Hurtel, Anne-Sophie; Bach, Véronique; Telliez, Frédéric

doi:10.1016/j.jpeds.2018.05.057

Cited by 12 publications

(7 citation statements)

References 57 publications

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“…The most common risk factor for GER is the physiologic consequences of prematurity, as these infants have an increased risk of GER events secondary to increased respiratory effort and transient increase in intraabdominal pressure resulting from airflow obstruction, this causes the LES tone to decrease and in turn contributes reflux [11]. 1; illustrated that (11.4%) of twin infants with GER were statistically significant differences (p value=0.004) in comparison to (0.0 %) of not twin infants in the control group other investigator had the same conclusion [12]. In addition to that, it is worthy to illustrate that, each of the four twins in this study was of identical gender which suggests the presence of monozygotic twinning; and implies the existence of a 100% concordance rate among twins Table 1 displayed that (44.3%) of GER infants were the first infant were statistically significant difference (p-value = 0.000) in comparison to (7.1%) of more than third order of the healthy infants, this finding might be due to increased experience of a mother in dealing with their regurgitated infant, bearing in mind that there was 91.4 % frequency of positive family history of GER.…”

Section: Discussionmentioning

confidence: 68%

New insight into risk factors for gastroesophageal reflux in infants

Suleiman

Al-Hafidh

2022

ijhs

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Background: Gastroesophageal reflux is a common problem in infancy. This study aimed to discover new risk factors that may contribute to gastroesophageal reflux in infants. Method and Materials: The current study adopted a case-control design to accomplish the objectives of the study for the period from 29th of December 2021 to 30th of June 2022. A probability sample was selected according to a systematic method for choosing the primary health care centers. A non-probability sample was purposively selected according to the inclusion and exclusion criteria of infants diagnosed with gastroesophageal reflux including a total of 140 infants aged from one month to twelve months, 70 infants with gastroesophageal reflux were in the study group and 70 infants in the healthy control group. Questionnaire form was applied to all participants at six enrolled primary health care centers in Mosul city. Results: The following studied hypothesized risk factors significantly differed between infants with gastroesophageal reflux and the healthy control group: twin infants (p=0.004), use of a pacifier (p=0.00), use of wrapping (p=0.00), exposure to smoking (p=0.00), family history of asthma (p=0.00), and starting position for infants (p=0.00).

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Section: Discussionmentioning

confidence: 68%

New insight into risk factors for gastroesophageal reflux in infants

Suleiman

Al-Hafidh

2022

ijhs

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“… Elimination of secondhand smoke. Tobacco is a common cause of GER/LPR in adults, and environmental smoking was also implied to cause reflux in infants and neonates [ 108 ]. Keeping an infant in a relatively vertical position for at least 30 min after feeding.…”

Section: Resultsmentioning

confidence: 99%

“…Elimination of secondhand smoke. Tobacco is a common cause of GER/LPR in adults, and environmental smoking was also implied to cause reflux in infants and neonates [ 108 ].…”

Section: Resultsmentioning

confidence: 99%

Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?

Sofokleous

Παπαδοπούλου

Giotakis

et al. 2023

JCM

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Background: Laryngopharyngeal reflux may affect people of any age; still, most of the accumulated knowledge concerns adults, and evidence regarding pediatric populations remains relatively restricted. This study aims to review the most recent and emerging aspects of pediatric laryngopharyngeal reflux from the last ten years. It also attempts to identify gaps in knowledge and highlight discrepancies that future research should urgently address. Methods: An electronic search of the MEDLINE database was conducted, limited to January 2012 through December 2021. Non-English language articles, case reports, and studies that concerned a purely or predominantly adult population were excluded. The information from the articles with the most relevant contribution was initially categorized by theme and subsequently synthesized into a narrative form. Results: 86 articles were included, of which 27 were review articles, eight were surveys, and 51 were original articles. Our review systematically maps the research done in the last decade and provides an updated overview and the current state-of-the-art in this subject. Conclusions: Despite discrepancies and heterogeneity in accumulating research, evidence gathered so far endorses a need for refining an escalating multiparameter diagnostic approach. A step-wise therapeutic plan appears to be the most reasonable management approach, starting with behavioral changes for mild to moderate, uncomplicated cases and escalating to personalized pharmacotherapy options for severe or nonresponsive cases. Surgical options could be considered in the most severe cases when potentially life-threatening symptoms persist despite maximal medical therapy. Over the past decade, the amount of available evidence has been gradually increasing; however, its strength remains low. Several aspects remain markedly under-addressed, and further adequately powered, multicenter, controlled studies with uniformity in diagnostic procedures and criteria are urgently needed.

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“…However, in children ages 7-11 years with overweight or obesity, there was no association between SRBD scores and passive smoke exposure when measured by plasma cotinine assay[104]. Also, in a small cohort of 31 neonates referred for PSG with suspected gastroesophageal reflux disease (GERD), there were no differences in sleep outcomes between exposed vs unexposed (as measured by urine cotinine assay), but there was a 2-fold greater number of reflux events in infants with exposure to passive smoke[98]. Overall, there’s good evidence that SHS exposure is associated with poor sleep outcomes in healthy children and with asthma, however, a limitation of the evidence is that all the studies have a cross- sectional design; therefore, a causal association for adverse sleep outcomes could not be ascertained.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of the 11 reviewed studies with ETS or SHS exposure reported positive associations between exposure and sleep disruption. Of these studies, only one included device-based measured sleep (PSG) [98] and found no association, and most assessed tobacco exposure through self-report. Of the 5 studies with measures of cotinine (a metabolite of nicotine), 2 reported associations with sleep impairment, while other results were null.…”

Section: Air Pollutionmentioning

confidence: 99%

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

Wallace

Gallagher

Peterson

et al. 2022

Preprint

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Background: Sleep disruption is a public health concern and environmental exposures that influence the biological processes underpinning sleep may contribute to impaired sleep health. However, the contributions of environmental chemical pollutants to sleep health have not been systematically investigated. Objectives: This systematic literature review sought to identify, evaluate, summarize, and synthesize the existing evidence between environmental chemical pollutant exposure and dimensions of sleep health in humans. We sought to evaluate potential mechanisms underlying exposure-outcome relationships and recommend areas for future research. Methods: Databases were searched for peer-reviewed published research on chemical environmental pollutants and sleep health and disorders with no date restriction up to the last search date of April 2021 (registered protocol PROSPERO # CRD42021256918), resulting in 9,918 records. Two reviewers independently screened identified records against inclusion and exclusion criteria, extracted study information, and performed risk of bias assessments. Results: We identified 204 studies of exposure to air pollution, exposures related to the Gulf War and other conflicts, endocrine disruptors, metals, pesticides, and solvents with dimensions of sleep health (architecture, duration, quality, timing) and sleep disorders (sleeping pill use, insomnia, sleep-disordered breathing) for inclusion in this review. Metals were the most frequently evaluated pollutants, while sleep maintenance/insomnia and quality were the most reported sleep outcomes. Synthesis of the evidence suggests mechanisms related to cholinergic signaling, neurotransmission, and inflammation as the most shared pathways. Discussion: Evidence indicates that exposure to particulate matter, secondhand smoke, dioxins and dioxin-like compounds, lead, mercury, pesticides, solvents, and exposures related to the Gulf War are associated with worse sleep health and disorders. Chemical pollutants are likely key environmental determinants of sleep health and disorders; thus, there is a need to improve measurement of pollutants and sleep, study rigor, and determine the populations most vulnerable to the effects of exposure.

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Effects of Smoking Exposure in Infants on Gastroesophageal Reflux as a Function of the Sleep–Wakefulness State

Cited by 12 publications

References 57 publications

New insight into risk factors for gastroesophageal reflux in infants

New insight into risk factors for gastroesophageal reflux in infants

Pediatric Laryngopharyngeal Reflux in the Last Decade: What Is New and Where to Next?

Is exposure to chemical pollutants associated with sleep outcomes? A systematic review

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