Effects of Smoking on Disease Activity and Radiographic Progression in Early Rheumatoid Arthritis

Ruíz-Esquide, Virginia; Gómez-Puerta, José A.; Cañete, Juan D.; Graell, Eduard; Vázquez, Ivonne; Ercilla, M. G.; Viñas, Odette; Gómez-Centeno, Antonio; Haro, Isabel; Sanmartí, Raimón

doi:10.3899/jrheum.110410

Cited by 40 publications

(26 citation statements)

References 14 publications

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“…A Swedish study reported that current smokers had a lower probability for a EULAR response or remission after 12 months in early RA patients 29 . However, a recent Spanish study with a similar setting did not show a significant effect of smoking 30 . Also, a study from CORRONA, in which the data structure was similar to ours, has not shown a significant effect of smoking cessation on disease activity 31 .…”

Section: Discussionmentioning

confidence: 75%

Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis

Lü

Rho²,

Cui³

et al. 2013

J Rheumatol

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Objective To investigate the associations of smoking and alcohol consumption with disease activity and functional status in rheumatoid arthritis (RA). Methods We conducted a prospective study consisting of 662 RA patients followed up to 7 years from the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study. Smoking and alcohol consumption were assessed through yearly questionnaires. The disease activity and functional status were measured by the Disease Activity Score examined in 28 commonly affected joints (DAS28-CRP3) and Modified Health Assessment Questionnaire (MHAQ) assessed annually. Linear mixed models were developed to assess the longitudinal effects of smoking and alcohol consumption on DAS28-CRP3 and MHAQ after adjustment for potential confounders. The HLA-DRB1 shared epitope (HLA-SE) by smoking and alcohol interactions were also evaluated in the analysis. Results The median follow-up time of the cohort was 4 years. Current smoking was not associated with DAS28-CRP3 in this study, but was associated with a higher MHAQ than non-smokers in seropositive RA (p=0.05). Alcohol consumption showed an approximate J-shaped relationship with MHAQ, with the minima occurring at 5.1–10.0 grams/day. Compared to no alcohol use, alcohol consumption of 5.1–10.0 grams/day was associated with a significant decrease of MHAQ (P=0.02). When stratified by HLA-SE, the effect of alcohol consumption appeared to be stronger in HLA-SE positive RA than HLA-SE negative RA. Conclusion We found that current smoking was associated with a worse functional status, while moderate alcohol consumption was associated with a better functional status in RA. Replications of these findings in other prospective studies are needed.

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Section: Discussionmentioning

confidence: 75%

Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis

Lü

Rho²,

Cui³

et al. 2013

J Rheumatol

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“…Os resultados deste estudo contrastam com os do estudo prospectivo de Vesperini et al, que demonstrou recentemente menor risco de progressão em pacientes com AR inicial, 24 mas estão de acordo com os resultados de outros dois estudos, 25,26 enquanto que o estudo de Ruiz-Esquide et al demonstrou maior progressão radiográfica em tabagistas. 27 Portanto, a associação entre tabagismo e progressão radiográfica ainda é controversa.…”

Section: Discussionunclassified

Coorte Sarar: atividade de doença, capacidade funcional e dano radiológico em pacientes com artrite reumatoide submetidos à artroplastia total de quadril e joelho

Cunha

Oliveira

Santos-Neto

2015

Revista Brasileira de Reumatologia

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“…Moreover, when comparing patients with a similar degree of radiographic joint destruction, women have worse scores for DAS28 and HAQ than men, possibly due to higher pain perception or an overestimate by men of their functional capacity [24]. Smoking is associated with a more severe disease and therefore probably more resistant to therapy [25, 26]. It also directly influences drug metabolism by inducing cytochrome P450 activity which was shown to impact other drug responses [27].…”

Section: Place Of Patient's Characteristics In Predicting Responsementioning

confidence: 99%

Predictive Factors of Response to Biological Disease Modifying Antirheumatic Drugs: Towards Personalized Medicine

Daïen

Morel

2014

Mediators of Inflammation

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Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characteristics of the patient such as age, gender, concomitant therapies, body mass index, or smoking status. Clinical response also depends on disease characteristics including disease activity and severity and presence of autoantibodies. Genetic background, cytokine levels, and immune cell phenotypes could also influence biological therapy response. This review summarizes the impact of all those parameters on response to biological therapies.

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Effects of Smoking on Disease Activity and Radiographic Progression in Early Rheumatoid Arthritis

Abstract: In patients with early RA, smoking was associated with earlier disease onset and the SE. Smoking was an independent factor of radiographic progression.

Cited by 40 publications

References 14 publications

Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis

Associations of Smoking and Alcohol Consumption with Disease Activity and Functional Status in Rheumatoid Arthritis

Coorte Sarar: atividade de doença, capacidade funcional e dano radiológico em pacientes com artrite reumatoide submetidos à artroplastia total de quadril e joelho

Predictive Factors of Response to Biological Disease Modifying Antirheumatic Drugs: Towards Personalized Medicine

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