2008
DOI: 10.1007/s11427-008-0098-5
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Effects of SO2 derivatives on sodium currents in acutely isolated rat hippocampal lead-exposed neurons

Abstract: In this study, the effects of acute SO2 derivatives and chronic lead exposure together on sodium currents (I(Na)) were investigated in acutely isolated rat hippocampal neurons by using the whole-cell patch clamp techniques. We found that chronic lead exposure hardly reduced the amplitudes of I(Na). In the normal condition, sodium current started to appear at around -70 mV, and reached the peak current at around -40 mV. After chronic lead exposure, the data changed to -70 and -30 mV. After adding SO2 derivative… Show more

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“…CdCl 2 0.2 mmol/L. 电极内液(mmol/L): CsCl 75, NaF 7.5, MgCl 2 2, HEPES 10, EGTA 2.5, Na 2 ATP 3, pH 7.5 [7] . 二氧化硫代谢衍生物的配制: 将 2.5 mmol/L NaHSO 3 和 7.5 mmol/L Na 2 SO 3 [6] .…”
unclassified
“…CdCl 2 0.2 mmol/L. 电极内液(mmol/L): CsCl 75, NaF 7.5, MgCl 2 2, HEPES 10, EGTA 2.5, Na 2 ATP 3, pH 7.5 [7] . 二氧化硫代谢衍生物的配制: 将 2.5 mmol/L NaHSO 3 和 7.5 mmol/L Na 2 SO 3 [6] .…”
unclassified