Effects of Sodium Cromoglycate and Nedocromil Sodium on Histamine Secretion from Mast Cells from Various Locations

Pearce, F. L.; Al-Laith, Mariam; Bosman, Laurens W. J.; Brostoff, Jonathan; Cunniffe, T M; Flint, K. C.; Hudspith, B N; Jaffar, Zeina; Johnson, N M; Kassessinoff, T.

doi:10.2165/00003495-198900371-00009

Cited by 51 publications

(20 citation statements)

References 7 publications

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“…In particular, the drug is almost totally without effect on human basophil leukocytes and mast cells from guinea pig tissues and the mouse peritoneum [21,25]. These results were confirmed in the present study and cGMP was shown to have an essential ly identical spectrum of activity, although some weak effect on mast cells from the guinea pig lung was observed.…”

Section: Discussionsupporting

confidence: 89%

Extracellular Guanosine 3′,5′-Cyclic Monophosphate and Disodium Cromoglycate Share a Similar Spectrum of Activity in the Inhibition of Histamine Release from Isolated Mast Cells and Basophils

Mackay

Pearce²

1996

Int Arch Allergy Immunol

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In comparison to adenosine 3′,5′-cyclic monophosphate (cAMP), surprisingly little is known regarding the role of guanosine 3′,5′-cyclic monophosphate (cGMP) in the functional modulation of mast cells and basophils. In the present study, the ability of cGMP, cAMP, and a range of related compounds, to inhibit immunologically induced histamine release from these cells was investigated and compared to the anti-asthmatic drug disodium cromoglycate (DSCG). Exogenously applied cGMP produced a potent inhibition of histamine release from rat peritoneal mast cells, but cAMP had a negligible effect. The attenuation noted with cGMP was markedly reduced if cells were pretreated with the nucleotide before stimulation. Similar results were obtained with DSCG. The inhibitory and tachyphylactic effects noted with cGMP were mimicked by direct derivatives of the compound but not by a range of other cyclic or guanosine nucleotides. The time courses of the induced tachyphylaxis seen with cGMP and DSCG were similar, and cross-tachyphylaxis between the two compounds was observed. In addition, both cGMP and DSCG showed a comparable spectrum of activity against mast cells isolated from the mouse, guinea pig, and human. The parallel effects of the two agents suggests that they may inhibit mediator release from mast cells through similar mechanisms.

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Section: Discussionsupporting

confidence: 89%

Extracellular Guanosine 3′,5′-Cyclic Monophosphate and Disodium Cromoglycate Share a Similar Spectrum of Activity in the Inhibition of Histamine Release from Isolated Mast Cells and Basophils

Mackay

Pearce²

1996

Int Arch Allergy Immunol

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“…Furthermore, the inhibitory potency of frusemide was totally removed when mast cells were preincubated with it for 10 min. This time dependent diminishing of inhibitor activity is similar to the characteristic tachyphylaxis of the prototype antiallergic compound DSCG [23]. DSCG has been known to inhibit mast cell activation by inhibiting the influx of extracellular calcium [24].…”

Section: Discussionmentioning

confidence: 68%

Inhibition of rat peritoneal mast cell exocytosis by frusemide: A study with different secretagogues

Stenton

Lau

1996

Inflamm Res

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It has been reported that the loop diuretic frusemide can prevent exercise induced asthma, and that this effect may be due to the inhibition of mast cells in the airway. By using various mast cell secretagogues which increase intracellular calcium via different routes, this study attempted to elucidate the mechanism of the mast cell stabilizing action of frusemide. As well as confirming that immunologically induced histamine release from rat peritoneal mast cells was dose dependently inhibited by frusemide (10(-3) - 10(-5) M), the present study has extended the observation to histamine release induced by compound 48/80. The inhibitory potency was however less in the case of compound 48/80 induced release. Frusemide induced inhibition by the two secretagogues was decreased by drug preincubation. In contrast, histamine release induced by ionophore A23187 and thapsigargin was not inhibited by frusemide. The prototype antiallergic compound disodium cromoglycate (DSCG) demonstrated a similar specificity pattern against the various secretagogues. Another loop diuretic, bumetanide, did not show the same results as frusemide on rat peritoneal mast cell degranulation. Hence it is concluded that frusemide does not inhibit immunological activation of mast cells via its diuretic Na+/K+/Cl- co-transporter capacity. Instead, it protects mast cells in a similar manner to DSCG.

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“…Both lodoxamide and nedocromil have been re ported to be effective in allergic conjunctivitis patients [8,9]. Nedocromil has also been reported to inhibit mast cell mediator release [10]. However, the present data demon strate that lodoxamide is 25 (7-200) times more potent an inhibitor of immediate hypersensitivity than nedocromil sodium.…”

mentioning

confidence: 51%

Effect of Lodoxamide on in vitro and in vivo Conjunctival Immediate Hypersensitivity Responses in Rats

Yanni

Weimer

Gläser

et al. 1993

Int Arch Allergy Immunol

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The antiallergic compound, lodoxamide, was evaluated for its abilities to attenuate a local allergic reaction in rat conjunctiva in vivo and to inhibit rat conjunctival mast cell mediator release in vitro. Topically applied lodoxamide (0.01, 0.10 and 1.0%, w/v) dose-dependently reduced the allergic response (23, 43 and 72%, respectively) in vivo. Lodoxamide was more effective than cromolyn sodium, N-acetyl aspartyl glutamic acid (Naaxia®) and levocabastine, and 25 (7–200) times more potent than nedocromil sodium in direct comparisons. Addition of lodoxamide (10 μg/ml) to sensitized conjunctival tissue in vitro immediately prior to antigen challenge significantly reduced the amount of histamine released by the tissue. These data suggest that lodoxamide’s in vivo antiallergic activity in the conjunctiva is associated with its ability to prevent allergic mediator release from mast cells contained in this same tissue.

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Effects of Sodium Cromoglycate and Nedocromil Sodium on Histamine Secretion from Mast Cells from Various Locations

Cited by 51 publications

References 7 publications

Extracellular Guanosine 3′,5′-Cyclic Monophosphate and Disodium Cromoglycate Share a Similar Spectrum of Activity in the Inhibition of Histamine Release from Isolated Mast Cells and Basophils

Extracellular Guanosine 3′,5′-Cyclic Monophosphate and Disodium Cromoglycate Share a Similar Spectrum of Activity in the Inhibition of Histamine Release from Isolated Mast Cells and Basophils

Inhibition of rat peritoneal mast cell exocytosis by frusemide: A study with different secretagogues

Effect of Lodoxamide on in vitro and in vivo Conjunctival Immediate Hypersensitivity Responses in Rats

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