Effects of Sodium Hyaluronate on Peridural Fibrosis After Lumbar Laminotomy and Discectomy

Songer, Matthew N.; Ghosh, Luna; Spencer, David

doi:10.1097/00007632-199006000-00022

Cited by 138 publications

(93 citation statements)

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“…However, there is no intrinsic binding capability ofthese lymphocytes to the dominant component of the wound matrix-. these tinaings support the hypothesis that added to an adult wound, fibrosis and scar formation can be decreased [24,25]. There appears to be a direct association between the extracellular matrix levels of this glycosaminoglycan and the degree of lymphocyte infiltration and inflammation within a wound environment.…”

Section: Resultssupporting

confidence: 75%

The Extracellular Matrix of the Fetal Wound: Hyaluronic Acid Controls Lymphocyte Adhesion

Dillon

Keefer

Blackburn

et al. 1994

Journal of Surgical Research

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Section: Resultssupporting

confidence: 75%

The Extracellular Matrix of the Fetal Wound: Hyaluronic Acid Controls Lymphocyte Adhesion

Dillon

Keefer

Blackburn

et al. 1994

Journal of Surgical Research

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“…21,22 The epidural venous systems are not disturbed during MED. This helps to prevent venous stasis and chronic nerve-root oedema.…”

Section: Discussionmentioning

confidence: 99%

Microendoscopic versus Open Discectomy for Lumbar Disc Herniation: A Prospective Randomised Study

Garg

Nagraja

Jayaswal

2011

J Orthop Surg (Hong Kong)

105

100

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Purpose.To compare the outcomes of microendoscopic discectomy (MED) versus open discectomy for lumbar disc herniation. Methods. 80 men and 32 women aged 26 to 57 (mean, 37) years with a single-level disc herniation were randomised to undergo MED (n=55) or open (fenestration/laminotomy) discectomy (n=57). Patients were assessed pre-and post-operatively (at week 6, month 6, and year one). The 2 groups were compared with respect to surgical time, anaesthesia time, duration of hospital stay, intra-operative blood loss, weight of disc material removed, and selfevaluated low back pain and functional outcome (using the Oswestry low back pain disability questionnaire). Results. Surgical and anaesthesia times were significantly longer, but blood loss and hospital stay were significantly reduced in patients having MED than open discectomy. The improvement in Microendoscopic versus open discectomy for lumbar disc herniation: a prospective randomised study Bhavuk Garg, Upendra Bidre Nagraja, Arvind Jayaswal Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India Address correspondence and reprint requests to: Dr Bhavuk Garg, Department Of Orthopaedics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 29, India. E-mail: drbhavukgarg@gmail.com 2011;19(1):30-4 the Oswestry score in both groups was significant at week one, but not at other follow-ups. The complication rate was similar in both groups. One patient with MED had a recurrence of disc herniation after 7 months and was treated with open discectomy. Conclusions. Both methods are equally effective in relieving radicular pain. MED entailed shorter hospital stay, less morbidity, and earlier return to work. Nonetheless, it is a demanding technique and should not be attempted without specific instruction and training. Journal of Orthopaedic Surgery

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“…A variety of biological, pharmacological and synthetic materials have been tested in vitro or used in vivo as space-occupying agents. Free or pedicle fat graft (Barberá et al, 1978), Silastic (Alkalay et al, 2003), methylene blue (Farrokhi et al, 2011), ADCON-L (Einhaus et al, 1997), Vicryl mesh (Nussbaum et al, 1990), methacrylate (Lawson et al, 1991), carboxymethyl cellulose (Rodgers et al, 2003), polyethylene oxide (Rodgers et al, 2003), haemostatic agents (Doğulu et al, 2009;Songer et al, 1995), mitomycin C (Lee et al, 2004;Lee et al, 2006), pimecrolimus , absorbable cement (Mehdi et al, 2014), topical high-molecularweight hyaluronan (Kato et al, 2005;Massie et al, 2005;Songer et al, 1990;Chen et al, 2014;Semra et al, 2015) and anti-inflammatory medications (Ross et al, 1996;Cekinmez et al, 2010) have been used with inconsistent results. Therefore, development of a new anti-adhesive material to prevent epidural fibrosis shall benefit spine laminectomy surgery.…”

Section: Mh Hu Et Almentioning

confidence: 99%

In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy

Yang²,

Sun

et al. 2017

eCM

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Post-operative epidural fibrosis is a biological response after laminectomy that may lead to clinical symptoms, such as radicular pain. An ideal material for prevention of epidural fibrosis should be able to inhibit fibroblast adhesions and reduce formation of scar tissue. An injectable hydrogel would be the material of choice for this purpose, since it could fill an irregular surgical defect completely, gelate in situ and be delivered in a minimally-invasive manner. The objective of this study was to evaluate, in vitro and in vivo, the cytocompatibility and anti-adhesive effect of an oxidised hyaluronic acid/adipic acid dihydrazide (oxi-HA/ADH) hydrogel. Different cell types present in the spine were used to test the cytocompatibility of the hydrogel. The hydrogel extraction medium had no deleterious effects on neural cells (PC-12), but reduced fibroblasts viability (NIH/3T3). Although the hydrogel did not change the release of lactate dehydrogenase from myoblasts (C2C12) and Schwann cells (RSC96), the extraction medium concentration slightly affected the mitochondrial activity of these two cell types. qPCR showed that the hydrogel down-regulated S100a and P4hb expression in NIH/3T3 cells, supporting the hypothesis that the hydrogel might inhibit fibroblast activity. The animal study showed a reduction of scar tissue formation as well as severity of adhesion between scar tissue and the dura mater in a rat laminectomy model. Superficially, the peel-off test showed significantly decreased tenacity. In conclusion, the oxi-HA/ADH hydrogel is a promising injectable and thermosensitive material for prevention of post-operative epidural fibrosis.

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Effects of Sodium Hyaluronate on Peridural Fibrosis After Lumbar Laminotomy and Discectomy

Cited by 138 publications

References 0 publications

The Extracellular Matrix of the Fetal Wound: Hyaluronic Acid Controls Lymphocyte Adhesion

The Extracellular Matrix of the Fetal Wound: Hyaluronic Acid Controls Lymphocyte Adhesion

Microendoscopic versus Open Discectomy for Lumbar Disc Herniation: A Prospective Randomised Study

In situ forming oxidised hyaluronic acid/adipic acid dihydrazide hydrogel for prevention of epidural fibrosis after laminectomy

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