2016
DOI: 10.1093/infdis/jiw392
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Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices During HIV Infection

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Cited by 15 publications
(15 citation statements)
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References 15 publications
(21 reference statements)
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“…In HIV-infected subjects, serum levels of ACE are elevated, compared with controls [ 43 ] and physiological activation of the RAAS by dietary salt-restriction is associated with activation of immune markers that does not occur in HIV-negative subjects [ 44 ]. RAAS activation is a major driver of tissue fibrosis, which impairs CD4+ T cell recovery in lymph nodes and contributes to metabolic abnormalities by affecting adipose tissue in HIV-infected subjects.…”
Section: The Renin-angiotensin Systemmentioning
confidence: 99%
“…In HIV-infected subjects, serum levels of ACE are elevated, compared with controls [ 43 ] and physiological activation of the RAAS by dietary salt-restriction is associated with activation of immune markers that does not occur in HIV-negative subjects [ 44 ]. RAAS activation is a major driver of tissue fibrosis, which impairs CD4+ T cell recovery in lymph nodes and contributes to metabolic abnormalities by affecting adipose tissue in HIV-infected subjects.…”
Section: The Renin-angiotensin Systemmentioning
confidence: 99%
“…Hypertension in PWH is common and a number of potential pathogenic mechanisms have been identified, including lipodystrophy, a pro-inflammatory state associated with the secretion of cytokines and adipokines, and renal disease [87]. HIV protease is molecularly homologous to renin, and renin levels are often inappropriately high [88, 89]. Hypertension is exacerbated by worsening endothelial dysfunction [87].…”
Section: Pathophysiological Mechanisms Associated With Development Ofmentioning
confidence: 99%
“…Fasting glucose(84±1 vs. 87±1mg/dL, P=0.08) and insulin(4[3,9] vs. 3[2,7]uIU/mL, P=0.14) were comparable between both HIV-infected and non-HIV-infected groups. At 120 minutes, glucose levels rose to similar levels within each group(129±8 vs. 114±11 mg/dL, change glucose P≤0.0001 and P=0.04, HIV and non-HIV).…”
Section: Resultsmentioning
confidence: 93%
“…ELISA was performed to quantify sCD163(Trillium Diagnostics, Bangor, ME), sCD14 and MCP-1(R&D Systems, Minneapolis, MN), key immune markers in HIV well-recognized for their relevance to IR and metabolic dysregulation[26]. …”
Section: Methodsmentioning
confidence: 99%