Effects of sodium selenite and L-selenomethionine on feed intake, clinically relevant blood parameters and selenium species in plasma, colostrum and milk from high-yielding sows

Falk, Michaela; Lebed, Pablo J.; Bernhoft, Aksel; Framstad, Tore; Kristoffersen, Anja Bråthen; Salbu, Brit; Oropeza-Moe, Marianne

doi:10.1016/j.jtemb.2018.12.009

Cited by 27 publications

(23 citation statements)

References 75 publications

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“…Nevertheless, in SeSP-supplemented rats, plasma selenium concentration was slightly lower than Se-supplemented rats. Interestingly, several studies obtained similar results (Cases et al, 2001;Suzuki et al, 2006;Takahashi et al, 2017), while others did not evidence any difference between sodium selenite-and spirulinaenriched supplementation (Falk et al, 2020;Zhang et al, 2020). When observed, the reduction of plasma selenium concentration in the SeSp group could be explained by the selenium form.…”

Section: Discussionmentioning

confidence: 80%

Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?

et al. 2021

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Section: Discussionmentioning

confidence: 80%

Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?

et al. 2021

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“…However, there are disagreements in previous studies on the effects of selenium on weight and food intake (Falk et al, 2019;Mechlaoui et al, 2019;Nido et al, 2016). These contradictions flow from to the utilization of various sorts of selenium supplements or different doses in combination with other materials.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Hasani

Saidpour

Irandoost

et al. 2021

Food Science & Nutrition

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This research investigated the effect of co‐supplementation of selenium with zinc on weight control and the inflammatory and oxidative status in relation to obesity. Male Wistar rats (N = 32) were randomly divided into four groups after induction of obesity model: 1) “Zn” was supplemented with zinc sulfate (15 mg/kg BW), 2) “Se” supplemented with selenium as sodium selenate (0.5 mg/kg BW), 3) “Zn + Se” which received Zn (15 mg/kg BW) + Se (0.5 mg/kg BW), and 4) “HFD” as the control group. The intervention was done for eight weeks. At the end of treatment, serum and tissue level of Zn, Se, SOD, GSH‐Px, MDA, leptin, TNF‐α, and IL‐6 was evaluated. Weight and food intake were significantly reduced in the Se group(p < .001), while in the Zn group, weight gain due to obesity was prevented compared to the control group (p = .48). There was a significant and stronger increase in SOD, GSH‐Px levels and a remarkable decrease in MDA, leptin, TNF‐α, and IL‐6 in the group receiving the combination of two supplements than either alone(p < .001). Leptin had a positive correlation with inflammatory factors and lipid peroxidation marker and showed an inverse relationship with Zn and Se levels and anti‐oxidative enzymes(p < .05). The analysis showed the mediating role of leptin in the effects of zinc. Co‐supplementation of selenium and zinc may have a synergistic effect in reduction of oxidative and inflammatory markers. Regarding the effect of zinc on inflammatory factors and lipid peroxidation, leptin can play a mediating role.

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“…SeMet and selenite both reduced 3,5‐dimethylaminophenol‐induced oxidative stress, DNA damage, and apoptosis in human urothelial cells, and SeMet at a concentration of 10 μmol/L exerted protecting effect equal to that of selenite at a concentration of 30 μmol/L (Erkekoglu et al., 2019). SeMet supplementation resulted in a higher feed intake and higher levels of total Se, SELENOP, SeAlb, and SeMet in sow colostrum than selenite supplementation (Falk et al., 2019). Compared to selenite, SeMet had a better effect on minimizing fluorosis‐induced oxidative stress and apoptosis, and increasing SELENOP concentration and GPX and TXNRD activities in broilers (Wang, Xiao, et al., 2018).…”

Section: Selenium Species In Cereals and Human Healthmentioning

confidence: 99%

Selenium in cereals: Insight into species of the element from total amount

Xie

Sun

et al. 2021

Comp Rev Food Sci Food Safe

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Selenium (Se) is a trace mineral micronutrient essential for human health. The diet is the main source of Se intake. Se‐deficiency is associated with many diseases, and up to 1 billion people suffer from Se‐deficiency worldwide. Cereals are considered a good choice for Se intake due to their daily consumption as staple foods. Much attention has been paid to the contents of Se in cereals and other foods. Se‐enriched cereals are produced by biofortification. Notably, the gap between the nutritional and toxic levels of Se is fairly narrow. The chemical structures of Se compounds, rather than their total contents, contribute to the bioavailability, bioactivity, and toxicity of Se. Organic Se species show better bioavailability, higher nutritional value, and less toxicity than inorganic species. In this paper, we reviewed the total content of Se in cereals, Se speciation methods, and the biological effects of Se species on human health. Selenomethionine (SeMet) is generally the most prevalent and important Se species in cereal grains. In conclusion, Se species should be considered in addition to the total Se content when evaluating the nutritional and toxic values of foods such as cereals.

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Effects of sodium selenite and L-selenomethionine on feed intake, clinically relevant blood parameters and selenium species in plasma, colostrum and milk from high-yielding sows

Cited by 27 publications

References 75 publications

Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?

Can selenium‐enriched spirulina supplementation ameliorate sepsis outcomes in selenium‐deficient animals?

Beneficial effects of Se/Zn co‐supplementation on body weight and adipose tissue inflammation in high‐fat diet‐induced obese rats

Selenium in cereals: Insight into species of the element from total amount

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