Effects of solifenacin in patients with neurogenic detrusor overactivity as a result of spinal cord lesion

Solifenacin is effective and well tolerated in patients with neurogenic detrusor overactivity: Results from the double‐blind, randomized, active‐ and placebo‐controlled SONIC urodynamic study

“…Although few studies have evaluated the efficacy of antimuscarinics in NDO, despite these agents being the first‐line treatment option, results from this study agree with the limited data previously reported. Of note, a retrospective observational study of 35 SCI patients receiving solifenacin for treatment of NDO concluded that solifenacin treatment significantly improved bladder capacity, detrusor compliance, reflex volume, and maximum detrusor pressure, although this open‐label study lacked a control group and should be cautiously interpreted . A recent systematic review and meta‐analysis of studies between 1966 to May 2011, identified 16 randomized clinical trials with a total of 960 patients investigating antimuscarinic agents in NDO .…”

“…Of note, a retrospective observational study of 35 SCI patients receiving solifenacin for treatment of NDO concluded that solifenacin treatment significantly improved bladder capacity, detrusor compliance, reflex volume, and maximum detrusor pressure, although this open-label study lacked a control group and should be cautiously interpreted. 18 A recent systematic review and meta-analysis of studies between 1966 to May 2011, identified 16 randomized clinical trials with a total of 960 patients investigating antimuscarinic agents in NDO. 2 In these studies, maximum detrusor pressure was reduced by $30% with antimuscarinic treatment.…”

Functional outcome of supratrigonal cystectomy and augmentation ileocystoplasty in adult patients with refractory neurogenic lower urinary tract dysfunction

“…The following urodynamic parameters were collected and evaluated: bladder capacity, detrusor compliance, maximum detrusor pressure during the storage phase and reflex volume, if applicable. Urodynamic results were considered favorable (no risk for renal damage), if the maximum detrusor pressure was ≤40 cm H 2 O and the detrusor compliance was ≥20 ml/cm H 2 O …”

Improving Outcomes in Patients With Refractory Idiopathic and Neurogenic Detrusor Overactivity: Management Strategies

“…Studies have demonstrated efficacy of at least 4 of them (oxybutynin, trospium chloride, tolterodine, darifenacin) in this patient population. 9,32,55,65 The detrusor muscle contains beta-adrenoceptors. Human bladder and urothelium contain beta1-, beta2-, and beta3-adrenoceptors 66 ; 97% of beta adrenoceptors in the human bladder are beta3.…”