Effects of Soman and DFP in vivo and in vitro on cerebral metabolism in the rat

Jović, R; Bachelard, H. S.; Clark, Andy; Nicholas, Peter C.

doi:10.1016/0006-2952(71)90138-9

Cited by 31 publications

(1 citation statement)

References 14 publications

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“…3) indicates that biosynthesis of fatty acids from 2-14Cacetate is also decreased during acute toxicity with Metasystox-R. Some organophosphates inhibit respiration by blocking electron transport in mitochondria (23) and others by inhibiting Naf-Kf ATPase, aldolase and succinic dehydrogenase in rat brain (7). It appears that Metasystox-R inhibits aerobic oxidation of U-14C-glucose and diverts the C-3 metabolites for biosynthesis of glycerolipids.…”

Section: Incorporation Of Labelled Precursors Into Lipidsmentioning

confidence: 99%

Effects of Metasystox-R and Lebaycid on Lipid Metabolism in Various Organs of Chicks (Gallus Domesticus)

Chopra

Gopal

Ahuja

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary The effects of acute and chronic toxicity due to Lebaycid (0.0‐dimethyl‐3‐methyl 4‐methylthiophenyl phosphorothionate) and Metasystox‐R (0.0‐dimethyl‐S‐2 [ethylsulphinyl] ethylthiophosphate) on lipid metabolism in various tissues of White Leghorn birds (Gallus domesticus) were studied by using 2‐14C‐acetate, U‐14C‐glucose and 32P‐phosphate. The incorporation of 14C glucose into total lipids of brain, spinal cord, sciatic nerves, liver and kidneys was increased and that of 2‐14C‐acetate was decreased by Metasystox‐R. Lebaycid had similar effects on the incorporation of U‐14C‐glucose but did not decrease the incorporation of 2‐14C‐acetate. The results suggest that Metasystox‐R inhibits the fatty acid synthetase complex and the enzymes of the TCA cycle, whereas Lebaycid does not inhibit the former. In nervous tissues and kidneys the two pesticides increase the degradation of phospholipids, whereas in liver they inhibit their biosynthesis as well. The possible mechanism of action of these pesticides involving the inactivation of coenzymes is discussed. Zusammenfassung Wirkungen von Metasystox‐R und Lebaycid auf den Lipidstoffwechsel verschiedener Organe des Haushuhnes Mittels 2‐14C‐Acetat, U‐14C‐Glukose und 32P‐Phosphat wurden bei Hühnern (weiße Leghorn) Effekte der akuten und chronischen Toxizität von Lebaycid(0,0‐Dimethyl‐3‐Methyl 4‐Methylthiophenyl Phosphorothionat) und Metasystox‐R (0,0‐Dimethyl‐S‐2 [Aethylsulphinyl] Aethylthiophosphat) auf den Lipidstoffwechsel verschiedener Gewebe untersucht. Metasystox‐R erhöhte die Aufnahme von 14C‐Glucose in die Totallipide des Gehirns sowie des Rückenmarks des N. ischiadicus, der Leber und Nieren, reduzierte hingegen diejenige von 2‐14C‐Acetat. Lebaycid hatte ähnliche Effekte auf die Inkorporation von U‐14C‐Glukose, reduzierte jedoch diejenige von 2‐14C‐Acetat nicht. Die Ergebnisse sprechen dafür, daß Metasystox‐R den Komplex der Fettsäure‐Synthetase sowie die Enzyme des Citronensäure‐Zyklus hemmt, während Lebaycid diese Enzyme nicht blockiert. Die zwei Pestizide erhöhen den Abbau von Phospholipiden im Nerven‐ und Nierengewebe während sie in der Leber auch deren Biosynthese hemmen. Der Wirkungsmechanismus der Pestizide hinsichtlich der Enzyminaktivierung wird besprochen. Résumé Actions de Metasystox‐R et de Lebaycid sur le métabolisme des lipides de différents organes chez la poule domestique On a recherché au moyen de 2‐14C‐acétate, U‐14C‐glucose et 32P‐phosphate chez des poules (Leghorn blanche) les effets de la toxicité aiguë et chronique de Lebaycid (0,0‐diméthyle‐3‐méthyle‐4‐méthylthiophényle phosphorothionate) et de Metasystox‐R (0,0‐diméthyle‐S‐2 [éthylsulphinyle]éthylthiophosphate) surle métabolimsme des lipides de différents tissus. Le Metasystox‐R a augmenté l'inclusion de 14C‐glucose dans les lipides totaux du cerveau, de la moëlle épinière, de N. ischiadicus, du foie et des reins, alors que l'inclusion de 2‐14C‐acétate fut diminuée. Le Lebaycid a eu les mêmes effets sur l'incorporation du U‐14C‐glucose, mais n'a pas réduit celle du 2‐14C‐acétate. Les rés...

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Section: Incorporation Of Labelled Precursors Into Lipidsmentioning

confidence: 99%

Effects of Metasystox-R and Lebaycid on Lipid Metabolism in Various Organs of Chicks (Gallus Domesticus)

Chopra

Gopal

Ahuja

2010

Zentralblatt Für Veterinärmedizin Reihe A

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The phytotoxicity of some methylphosphonofluoridates

Howells¹,

Hambrook²

1972

Pestic. Sci.

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The phytotoxicity of some 0-alkyl methylphosphonofluoridates has been studied by examining the effects of the compounds and their likely breakdown products on the germination of wheat seed and on the growth of wheat seedlings (14 to 18 days old) in hydroponic culture. The four 0-alkyl methylphosphonofluoridates (ethyl; isopropyl; 3,3-dimethylbut-2-yl(pinacolyl) and cyclohexyl) were found to be phytotoxic and the phytotoxicity was shown to be a property of thecompounds as such and not of their breakdown products. The phytotoxicity of the phosphonofluoridates was apparently influenced by the nature of the 0-alkyl group and tended to increase as follows: ethyl < isopropyl< pinacolyl < cyctohexyl.

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Target Sites for Anticholinesterases, Cholinolytics and Oximes on Ventral Medulla Oblongata

Edery

1983

Proceedings in Life Sciences

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Effects of Soman and DFP in vivo and in vitro on cerebral metabolism in the rat

Cited by 31 publications

References 14 publications

Effects of Metasystox-R and Lebaycid on Lipid Metabolism in Various Organs of Chicks (Gallus Domesticus)

Effects of Metasystox-R and Lebaycid on Lipid Metabolism in Various Organs of Chicks (Gallus Domesticus)

The phytotoxicity of some methylphosphonofluoridates

Target Sites for Anticholinesterases, Cholinolytics and Oximes on Ventral Medulla Oblongata

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