Effects of some drugs on the responses of the rat isolated, innervated urinary bladder to indirect electrical stimulation

Dhattiwala, A. S.; Jindal, M N; Kelkar, V. V.

doi:10.1111/j.1476-5381.1970.tb09900.x

Cited by 13 publications

(3 citation statements)

References 15 publications

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“…This is similar to previous findings in rats and rabbits and guinea pigs (Dhattiwala et al 1970;Hukovic et al 1965;Krell et al 198 1;Vanov 1965).…”

Section: Downie and Beansupporting

confidence: 93%

Human female bladder and its noncholinergic contractile function

Cowan¹,

Daniel²

1983

Can. J. Physiol. Pharmacol.

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The response of human female detrusor muscle to field stimulation at varying voltages, durations, and frequencies was studied in vitro. In addition, the effects of adrenergic and cholinergic agonists and antagonists, and various nerve toxins were studied. Beta-adrenergic receptors were found in detrusor muscle but no significant adrenergic innervation was seen; no alpha-adrenergic receptors were seen. Atropine, scorpion venom, tetrodotoxin, beta bungarotoxin and hemicholinium were found to inhibit bladder contraction at short-pulse durations and low frequencies by approximately 50%. Black widow spider venom was seen to abolish bladder contractions entirely. It is concluded that acetylcholine is the neurotransmitter responsible for approximately 50% of bladder contraction. The remaining 50% would seem to be noncholinergic and not dependent on fast sodium channels for transmission of excitation, but would seem to be due to a structure with a short-membrane time constant, such as nerve, and is sensitive to black widow spider venom.

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“…This is similar to previous findings in rats and rabbits and guinea pigs (Dhattiwala et al 1970;Hukovic et al 1965;Krell et al 198 1;Vanov 1965).…”

Section: Downie and Beansupporting

confidence: 93%

Human female bladder and its noncholinergic contractile function

Cowan¹,

Daniel²

1983

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Morphine and other opiates inhibit electrically stimulated bladder contractions but the response is not blocked by the opioid receptor antagonist naloxone and so it is not mediated by opioid receptors [Dhattiwala et al, 1970;Acevedo et al, 1986;Berggren et al, 1991]. Bladder contractions are also inhibited by opioids that are structurally di¡erent than morphine including loperamide, a phenylpiperidine [Berggren et al, 1991] and methadone, a phenylheptylamine [Acevedo et al, 1986] and these e¡ects are also una¡ected by naloxone pretreatment.…”

Section: Discussionmentioning

confidence: 91%

“…Perhaps the most direct way in which opioids might cause urinary retention is by inhibiting detrusor muscle contractions within the bladder. Morphine inhibits electrically stimulated bladder concentrations in vitro at relatively high concentrations [Dhattiwala et al, 1970;Acevedo et al, 1986;Berggren et al, 1991]. Bladder contractions are also inhibited by opioids that are markedly di¡erent than morphine, structurally, including loperamide, a phenylpiperidine [Berggren et al, 1991], and methadone, a phenylheptylamine [Acevedo et al, 1986].…”

Section: Introductionmentioning

confidence: 97%