Effects of some typical and atypical antidepressants on schedule‐controlled responding in rats

Rastogi, Shiva K.; McMillan, D. E.

doi:10.1002/ddr.430050307

Cited by 12 publications

(8 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, high rate behaviors are typically more sensitive to rate-decresing effects of some drugs than low rate behaviors. In previous studies, fluvoxamine or other SSRIs did not exert ratedependent effects in rats and pigeons (Rastogi and McMillan, 1985;Lamb and McMillan, 1986). In the present study, behaviors maintained at higher response rates tended to be less sensitive to disruption by fluvoxamine which is opposite of the relationship expected due to rate-dependent effects.…”

Section: Discussioncontrasting

confidence: 85%

Fluvoxamine effects on concurrent ethanol- and food-maintained behaviors.

Ginsburg

Lamb

2006

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

In previous studies, the selective serotonin reuptake inhibitor fluvoxamine preferentially reduced responding for ethanol compared with responding for food under conditions in which each was available alone in separate groups or in the same subjects under a multiple schedule in which baseline response rates were matched. The impact of providing concurrent access to food on pharmacological effects on ethanol self-administration remains largely unexplored. In this study, acute doses of fluvoxamine (3.0-17.8 mg/kg) were administered 30-min before the experimental session to Lewis rats responding under a concurrent fixed-ratio, fixed-ratio schedule of ethanol and food presentation. Ratios for food were adjusted for each subject to provide matched rates of food and ethanol reinforcement across the 30-min session. Although the number of ethanol and food deliveries did not significantly differ under baseline conditions, response rates did differ. Following fluvoxamine administration, responding for food was decreased more than responding for ethanol. This differential effect did not appear to be related to response rate or fixed-ratio size. Thus, the selectivity of fluvoxamine on ethanol-versus food-maintained responding depends upon the context in which the behavior occurs. Such results may help explain inconsistencies between preclinical results and those in humans, and could provide insight into the behavioral determinants of pharmacological effects on ethanol self-administration. Keywordsoperant; alcoholism; alcohol; SSRI; lever-press; Lewis rat; concurrent schedule; foodThe development of methods to study ethanol-maintained behavior has led to a greater understanding of the neurobiology of as well as a means for searching for potential treatments for alcoholism (Meisch and Henningfield, 1977;Samson, 1986). Methods of studying ethanol self-administration have been refined since the earliest reports (see Samson et al., 2000). Among these refinements is the incorporation of the concept of a therapeutic index. For example, a potential pharmacotherapy for alcoholism should reduce behavior maintained by ethanol, but not (or at least to a lesser extent) reduce behavior maintained by Publisher's Disclaimer:The following manuscript is the final accepted manuscript. It has not been subjected to the final copyediting, fact-checking, and proofreading required for formal publication. It is not the definitive, publisher-authenticated version. The American Psychological Association and its Council of Editors disclaim any responsibility or liabilities for errors or omissions of this manuscript version, any version derived from this manuscript by NIH, or other third parties. The published version is available at www.apa.org/pubs/journals/PHA NIH Public Access Author ManuscriptExp Clin Psychopharmacol. Author manuscript; available in PMC 2011 October 27. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript other events. Further, more attention has been focused on controlling parameters known to be det...

show abstract

Section: Discussioncontrasting

confidence: 85%

Fluvoxamine effects on concurrent ethanol- and food-maintained behaviors.

Ginsburg

Lamb

2006

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…The effects of reinforcement density on behavioral momentum are similar in rats and pigeons (Cohen et al 1993), but there are perhaps reasons to suspect that the rate-dependent effects of antidepressants such as fluvoxamine and desipramine do vary between the two species with antidepressants being more likely to exhibit rate-dependent effects in the pigeon than in the rat (compare results with rats and pigeons in Lamb & McMillan, 1986, 1989Leander & Carter, 1984;Rastogi & McMillan, 1985). As the evidence against reinforcement magnitude explaining the specificity observed in rat ethanol self-administration studies comes from experiments in pigeons, it is important to examine if the potential (but not readily observed) rate-dependent effects of fluvoxamine in pigeons might explain the lack of modulation of fluvoxamine's rate decreasing effects by reinforcement magnitude.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 97%

“…In particular, rate dependent effects, particularly with norepinephrine uptake inhibitors, are frequently seen in pigeons (e.g., Leander & Carter, 1984;Lamb & McMillan, 1989), but not in rats (Rastogi & McMillan, 1985;Lamb & McMillan, 1989). These species differences limit the extent to which reinforcement magnitude modulation of the rate dependent effects of fluvoxamine or desipramine should be directly extended from the pigeon to the rat without more direct investigation.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

Reinforcement magnitude modulates the rate-dependent effects of fluvoxamine and desipramine on fixed-interval responding in the pigeon

Lamb

Ginsburg²

2008

Behavioural Pharmacology

View full text Add to dashboard Cite

Some doses of fluvoxamine can decrease ethanol-maintained behavior more than food-maintained behavior. This might be explained by differences in reinforcement magnitude. In a previous study, the effects of fluvoxamine on fixed-ratio responding did not depend upon reinforcement magnitude. Response rates, however, differed with reinforcement magnitude. These differences in response rates might explain the failure to observe differences in the potency of fluvoxamine with changes in reinforcement magnitude. In this study, we examined whether the effects of fluvoxamine and desipramine depended on the reinforcement magnitude and response rate, by administering these drugs to pigeons responding under a multiple fixed-interval schedule, in which responding in three components was maintained by differing durations of food presentation (2, 4, and 8 s). The effects of fluvoxamine and desipramine depended jointly on control rate, reinforcement magnitude, and dose. Low fluvoxamine doses had rate-dependent effects in all three components, increasing lower rates more than higher rates: as dose increased, these rate-dependent effects became greater in the components maintained by the 2-s or 4-s food presentation; whereas, in the component maintained by the 8-s presentations, they declined. Low desipramine doses had rate-dependent effects only in the component maintained by the 2-s presentations, whereas higher doses had rate-dependent effects in components maintained by 2-s or 4-s presentations. Still higher doses had rate-dependent effects in all the three components. Although the effects of fluvoxamine and desipramine might not depend on reinforcement magnitude when studied under fixed-ratio schedules, reinforcement magnitude can modulate their effects when they are studied over a wider range of control response rates.

show abstract

“…These drugs have been shown to alter rates and patterns of schedule-controlled behaviour (Leander and Carter 1984;Rastogi and McMillan 1985;Lamb and McMillan 1986) but, in general, these effects do not distinguish antidepressants, as a psychopharmacological category, from other drugs. However, Seiden, O'Donnell and their colleagues have recently presented results showing that many chemically and pharmacologically diverse antidepressants give rise to similar changes in the responding of rats maintained by differential reinforcement of low rate (DRL) schedules (McGuire and Seiden 1980;Seiden 1982, 1983;Seiden and O'Donnell 1985;Seiden et al 1985).…”

mentioning

confidence: 99%

The ?2-adrenoceptor antagonists idazoxan and yohimbine increase rates of DRL responding in rats

Sanger

1988

Psychopharmacology

View full text Add to dashboard Cite

Previous studies have reported that antidepressant drugs exert specific effects on responding maintained by DRL schedules of reinforcement, giving rise to increased frequencies of reinforcement. In order to investigate whether the alpha 2-adrenoceptor antagonist idazoxan would produce similar effects, the actions of this compound were compared with those of yohimbine, imipramine, mianserin and d-amphetamine in rats trained to lever press for food reinforcement on a DRL 60-s schedule. Neither imipramine nor mianserin produced any effects on response rate or reinforcement frequency, except at the highest doses. In contrast, both idazoxan and yohimbine gave rise to dose-related increases in rates of responding and consequent decreases in reinforcement frequencies. Amphetamine also increased responding, but higher doses of this drug produced marked hyperactivity and stereotyped movements which were not observed after idazoxan and yohimbine. Although the present behavioural baseline was not sensitive to antidepressants, it demonstrated an unexpected activity of two alpha 2-adrenoceptor antagonists which deserves further investigation.

show abstract

Effects of some typical and atypical antidepressants on schedule‐controlled responding in rats

Cited by 12 publications

References 15 publications

Fluvoxamine effects on concurrent ethanol- and food-maintained behaviors.

Fluvoxamine effects on concurrent ethanol- and food-maintained behaviors.

Reinforcement magnitude modulates the rate-dependent effects of fluvoxamine and desipramine on fixed-interval responding in the pigeon

The ?2-adrenoceptor antagonists idazoxan and yohimbine increase rates of DRL responding in rats

Contact Info

Product

Resources

About