Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

Sachdeva, Sean; Persaud, Sushmita; Patel, Milani; Popard, Peyton; Colverson, Aaron; Doré, Sylvain

doi:10.3390/brainsci12060742

Cited by 10 publications

(4 citation statements)

References 40 publications

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“…The result shows that music and sound interventions do, in fact, contribute to the opening of the BBB and subsequently increase the function of the meningeal lymphatic system. Evidence also suggests that music/sound can reduce the collateral effects of brain injuries [28]. The brain's lymphatic drainage after opening the BBB is beautifully demonstrated in ref.…”

Section: Discussionmentioning

confidence: 95%

Long COVID, Music, BBB, and Nanomedicines

Contreras¹,

Pavláth

Försterling

et al. 2022

Precision Nanomedicine

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At the beginning of the first COVID-19 wave, it was believed that the life of the patients who had safely survived pulmonary complications caused by SARS-CoV-2 would soon return to normal. Today, we know that this is not for all patients the case. Unfortunately, for many patients, COVID-19 changed into long COVID – not a life-threatening condition such as the short period of the infection with the coronavirus but with the potential to considerably reduce the quality of life. Notably, long COVID manifests itself in major pathological alteration in the brain, besides other organs. It is unclear whether the alterations in the brain are reversible. Alterations can include but are not limited to cognitive impairment and substantial reduction of grey matter. These clinical findings represent an urgent challenge for the design of nanomedicines targeting the brain and the mode of their application. The challenge comprises a third aspect, which is of physical nature and is the key to a revolution in nanomedicine: the blood-brain barrier (BBB). Even if nanomedicine is effective in vitro, it remains therapeutically useless if it cannot cross the BBB, safeguarding that neither pathogens nor nanoparticles enter the best-protected organ in our body. Here, we present a theoretical model and discuss experimental results, which coherently indicate that it can transiently open the BBB by its mechanical excitation and/or via chemical modification induced by music.

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Section: Discussionmentioning

confidence: 95%

Long COVID, Music, BBB, and Nanomedicines

Contreras¹,

Pavláth

Försterling

et al. 2022

Precision Nanomedicine

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show abstract

“…In addition, a novel method using the noninvasive music-induced opening of the BBB stimulates lymphatic A␤ clearance [56]. Another study indicated that sound/music facilitates the opening of the BBB, accelerates waste clearance from mLVs, and subsequently improves cognitive function [57]. When the BBB opens with high permeability, the meningeal vascular diameter increases, triggering solute flow from mLVs to the lymph nodes.…”

Section: Dysfunction Promotes A␤ Accumulationmentioning

confidence: 99%

“…Thus, the BBB and mLVs cooperate with each other to facilitate the removal of metabolic waste. However, the underlying mechanisms bridging the BBB and meningeal lymphatic drainage remain to be elucidated [57].…”

Section: Dysfunction Promotes A␤ Accumulationmentioning

confidence: 99%

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease

Zhang

Peng

Huang

et al. 2023

JAD

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Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into deep cervical lymph nodes. Aging and ApoE4, the two most important risk factors for Alzheimer’s disease (AD), induce mLV dysfunction, decrease cerebrospinal fluid influx and outflux, and exacerbate amyloid pathology and cognitive dysfunction. Dysfunction of mLVs results in the deposition of metabolic products, accelerates neuroinflammation, and promotes the release of pro-inflammatory cytokines in the brain. Thus, mLVs represent a novel therapeutic target for treating neurodegenerative and neuroinflammatory diseases. This review aims to summarize the structure and function of mLVs and to discuss the potential effect of aging and ApoE4 on mLV dysfunction, as well as their roles in the pathogenesis of AD.

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“…There is not yet a complete understanding of its beneficial biomedical and psychological effects, but the proposed actions are said to focus on the cerebral structures involved in emotivity and decision functionality, "including sympathetic arousal and dopaminergic circuit activation" [13]. However, generally, melotherapy (neurologic music therapy) is considered in some of the literature data to have the capability of mitigating the expansion of neurodegenerative pathologies such as AD, including combating the related reduction in social relationships and possibly even actions like ameliorating motor impairments that frequently appear after brain lesions [136]. Therefore, the enhanced availability of music is to be considered in domiciliary settings such as "daycare centers and nursing homes" [137].…”

Section: Music and Dancingmentioning

confidence: 99%

Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer’s Disease—A Systematic Review

Aurelian,

Ciobanu,

Cărare

et al. 2023

IJMS

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One of the most complex and challenging developments at the beginning of the third millennium is the alarming increase in demographic aging, mainly—but not exclusively—affecting developed countries. This reality results in one of the harsh medical, social, and economic consequences: the continuously increasing number of people with dementia, including Alzheimer’s disease (AD), which accounts for up to 80% of all such types of pathology. Its large and progressive disabling potential, which eventually leads to death, therefore represents an important public health matter, especially because there is no known cure for this disease. Consequently, periodic reappraisals of different therapeutic possibilities are necessary. For this purpose, we conducted this systematic literature review investigating nonpharmacological interventions for AD, including their currently known cellular and molecular action bases. This endeavor was based on the PRISMA method, by which we selected 116 eligible articles published during the last year. Because of the unfortunate lack of effective treatments for AD, it is necessary to enhance efforts toward identifying and improving various therapeutic and rehabilitative approaches, as well as related prophylactic measures.

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Effects of Sound Interventions on the Permeability of the Blood–Brain Barrier and Meningeal Lymphatic Clearance

Cited by 10 publications

References 40 publications

Long COVID, Music, BBB, and Nanomedicines

Long COVID, Music, BBB, and Nanomedicines

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer’s Disease

Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer’s Disease—A Systematic Review

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