Effects of South African traditional medicine in animal models for depression

Pedersen, M. E.; Szewczyk, Bernadeta; Stachowicz, Katarzyna; Wierońska, Joanna M.; Andersen, Jacob; Stafford, G.I.; Staden, J. Van; Pilc, Andrzej; Jäger, Anna K.

doi:10.1016/j.jep.2008.08.030

Cited by 54 publications

(42 citation statements)

References 24 publications

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“…Also, Patnam et al (2005) isolated chlorinated coumarinolignan from the roots of M. whitei. The plant showed promising in vitro antidepressant properties (Pedersen et al, 2008). The non-toxic effect of the plant in mice has also been reported (Kuo et al, 2006).…”

Section: Resultsmentioning

confidence: 89%

Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

Gbadamosi¹,

Aboaba²

2016

J. Pharmacognosy Phytother.

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Section: Resultsmentioning

confidence: 89%

Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

Gbadamosi¹,

Aboaba²

2016

J. Pharmacognosy Phytother.

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“…Currently, 12.3% of world population suffer from depression, and it is predicted that by 2020, the number may rise to 15%. [ 1 ] Ravindran and da Silva[ 2 ] have reported that about 7% of the Indian population suffers from mood and anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine

Kaur

Invally

Sanzagiri

et al. 2015

J Ayurveda Integr Med

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Background:The prevalence of mental depression has increased in recent years, and has become a serious health problem in most countries of the world, including India. Due to the high cost of antidepressant synthetic drugs and their accompanying side effects, the discovery of safer antidepressant herbal remedies is on the rise. Moringa oleifera (MO) (drumstick) has been used in traditional folk medicine, and in Ayurveda, it is considered as a valuable remedy for treating nervous system disorders as well as memory enhancing agent.Objective:The present study was designed to evaluate the acute and chronic behavioral and antidepressant effects of alcoholic extracts of MO leaves in standardized mouse models of depression.Materials and Methods:Alcoholic extracts of MO (MOE) leaves were prepared, and phytoconstituents were determined using appropriate chemical analytical methods. Following preliminary dose-finding toxicity studies, the biological activity of MOE was tested in Swiss albino mice. Animals were divided into six groups: Groups 1 and 2 served as vehicle control and fluoxetine (20 mg/kg) standard control, respectively. Groups 3 and 4 served as treatment groups and were orally administered ethanolic MOE at doses of 100 mg/kg and 200 mg/kg, respectively. Groups 5 and 6, respectively, received combination doses of MOE 100 mg/kg + 10 mg fluoxetine, and MOE 200 mg/kg + 10 mg/kg fluoxetine. Following acute and 14 days chronic treatments, all animals were tested using behavioral models of depression, such as forced swim test (FST), tail suspension test (TST), and locomotor activity test (LAT).Results:Significant changes in all tested activities (FST, TST, LAT) of chronically dosed mice were observed, especially in animals given simultaneously combined doses of 200 mg/kg/day MOE + 10 mg/kg/day fluoxetine for 14 days. The antidepressant effect of MOE may have been invoked through the noradrenergic-serotonergic neurotransmission pathway, which is the hallmark of selective serotonin reuptake inhibitors (SSRI) class of drugs.Conclusion:The results obtained in this study suggest that combined administration of MOE with low doses of fluoxetine or other SSRI drugs seems to have promising potential.

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“…65 The cytotoxicity of lycorine in Trichomonas vaginalis are different compared with its activities against a variety of tumor cell lines mentioned before. For depression study, Pedersen et al 80 However, some similarities to paraptotic cell death described for multicellular organisms were observed.…”

Section: Antibacterial Activitiesmentioning

confidence: 93%

Biological and pharmacological activities of amaryllidaceae alkaloids

et al. 2015

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The amaryllidaceae family consists of about 75 genera and 1100 species that are wide-spread in the tropics and warm temperate regions of the world. Since the first isolation of lycorine, more than 500 amaryllidaceae alkaloids have been isolated over the past three decades. The enormous numbers of diverse amaryllidaceae alkaloids are classified into different groups mainly according to their structural features. The representative alkaloids are norbelladine, lycorine, hippeastrine, narwedine, haemanthamine, pancratistatin, pretazettine, montanine, galanthindole, cherylline and ismine. Recently, more extensive studies have revealed that amaryllidaceae alkaloids exhibit a wide range of bioactivities, such as antitumor, antiviral, antibacterial, antifungal, antimalarial and analgesic. Acetylcholinesterase (AChE) inhibitory and cytotoxic activities have also been reported. The aim of the present review is to discuss the recent developments on the biological and pharmacological activities of amaryllidaceae alkaloids with IC 50 or EC 50 values since 2005, supporting the potential therapeutic possibilities for the use of these compounds.

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Effects of South African traditional medicine in animal models for depression

Cited by 54 publications

References 24 publications

Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

Essential oil constituents and in vitro antimicrobial activity of the root of Mondia whitei (Hook. F.) Skeels (Periplocaceae)

Evaluation of the antidepressant activity of Moringa oleifera alone and in combination with fluoxetine

Biological and pharmacological activities of amaryllidaceae alkaloids

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