Effects of stachyose on absorption and transportation of tea catechins in mice: possible role of Phase II metabolic enzymes and efflux transporters inhibition by stachyose

Li, Wenfeng; Lu, Ya-Cheng; Huang, Di; Han, Xiao; Yang, Xingbin

doi:10.3402/fnr.v60.32783

Cited by 7 publications

(3 citation statements)

References 33 publications

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“…We suppose that this may be related to the fact that stachyose promotes the absorption of tea polyphenols in mice Li, Lu, Huang, Han, & Yang, 2016).…”

Section: Discussionmentioning

confidence: 99%

Stachyose combined with tea polyphenols mitigated metabolic disorders in high fructose diet-fed mice as studied by GC-MS metabolomics approach

et al. 2018

CyTA - Journal of Food

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(2018) Stachyose combined with tea polyphenols mitigated metabolic disorders in high fructose diet-fed mice as studied by GC-MS metabolomics approach, CyTA -Journal of Food, 16:1,[516][517][518][519][520][521][522][523][524] To link to this article: https://doi.org/10. 1080/19476337.2017 High fructose (HF) ingestion is a common risk factor for the development of nonalcoholic fatty liver disease (NAFLD), which has become a serious health problem. The underlying mechanism of HFinduced NAFLD needs to be further understood and an effective prevention needs to be established urgently. Gas chromatography-mass spectrometer-based metabonomic method was employed to characterize the serum metabolic profile of HF-induced NAFLD in mice. β-Hydroxybutyric acid, elaidic acid and oleic acid that contributed to energy and lipid metabolism were confirmed as potential biomarkers for HF-induced NAFLD. With these changed metabolic pathways as possible drug targets, different administrations revealed that co-administration of stachyose and tea polyphenols was a more effective method than treatment of stachyose or tea polyphenols alone for preventing HF-induced negative changes of metabolic pathways in mice. These findings suggest that β-hydroxybutyric acid, elaidic acid and oleic acid are potential biomarkers in HF-induced NAFLD, and co-administration is a novel preventive strategy.Estaquiosa combinada con polifenoles de té para mitigar los trastornos metabólicos en ratones alimentados con una dieta alta en fructosa, estudio realizado mediante un enfoque metabolómico GC-MS RESUMEN La ingesta elevada de fructosa (HF) constituye un factor de riesgo común en el desarrollo de esteatohepatitis no alcohólica (NAFLD), padecimiento que se ha convertido en un problema de salud serio. El mecanismo subyacente de la NAFLD inducida por HF debe ser mejor comprendido, al tiempo que urge establecer mecanismos de prevención que resulten efectivos. En este sentido, para caracterizar el perfil metabólico del suero de ratones con NAFLD inducida por HF se utilizó el método metabolómico basado en GC-MS. Ello permitió constatar que los ácidos betahidroxibutírico, elaídico y oleico, que contribuyen al metabolismo energético y lipídico, son biomarcadores potenciales para la NAFLD inducida por el HF. A partir de la identificación de estas vías metabólicas alteradas como posibles dianas de los medicamentos, la administración diferenciada de sustancias (combinadas o por separado) reveló que, para prevenir los cambios negativos inducidos por la HF en las vías metabólicas de ratones, la coadministración de estaquiosa y polifenoles de té resultó ser un método más efectivo que el tratamiento con estaquiosa o con polifenoles de té por separado. Estos hallazgos sugieren que los ácidos betahidroxibutírico, elaídico y oleico son biomarcadores potenciales para la NAFLD inducida por HF y que la coadministración constituye una estrategia preventiva innovadora. ARTICLE HISTORY

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“…We suppose that this may be related to the fact that stachyose promotes the absorption of tea polyphenols in mice Li, Lu, Huang, Han, & Yang, 2016).…”

Section: Discussionmentioning

confidence: 99%

Stachyose combined with tea polyphenols mitigated metabolic disorders in high fructose diet-fed mice as studied by GC-MS metabolomics approach

et al. 2018

CyTA - Journal of Food

Self Cite

View full text Add to dashboard Cite

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“…Furthermore, the bioavailability of polyphenols depends on multi-drug resistance proteins on the cell membrane surface 45 and p-glycoproteins 46 . Recent studies involving human models considered the evidence on absorption, distribution, metabolism, and bioavailability.…”

Section: Bioavailability Of Polyphenolsmentioning

confidence: 99%

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Mamun,

Shao,

Geng

et al. 2024

Int. J. Biol. Sci.

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Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs). Numerous studies have reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting the phosphorylation or ubiquitination of signaling molecules, which further prevents the degradation of IκB. Additionally, they prevent NF-κB translocation to the nucleus and pro-inflammatory cytokine production. Polyphenols such as curcumin, resveratrol, and pterostilbene had significant inhibitory effects on NF-κB, making them promising candidates for treating NDs. Recent experimental findings suggest that polyphenols possess a wide range of pharmacological properties. Notably, much attention has been directed towards their potential therapeutic effects in NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, anxiety, depression, autism, and spinal cord injury (SCI). Much preclinical data supporting the neurotherapeutic benefits of polyphenols has been developed. Nevertheless, this study has described the significance of polyphenols as potential neurotherapeutic agents, specifically emphasizing their impact on the NF-κB pathway. This article offers a comprehensive analysis of the involvement of polyphenols in NDs, including both preclinical and clinical perspectives.

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“…Nanostructure-based delivery systems are a topic of keen interest in increasing the plasma concentration of EGCG, with the attributes of enhancing the solubility of EGCG, preventing degradation in the intestinal environment, and elevating the permeation in the small intestine. 8 It has also been reported that specific combinations of food factors such as L-ascorbic acid and sucrose, 9 genistein, 10 piperine, 11 quercetin, 12 and stachyose 13 can improve the bioavailability of EGCG.…”

Section: ■ Introductionmentioning

confidence: 99%

Fructooligosaccharides Increase in Plasma Concentration of (−)-Epigallocatechin-3-Gallate in Rats

Unno

Araki²,

Inagaki³

et al. 2021

J. Agric. Food Chem.

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Metrics & MoreArticle Recommendations * sı Supporting Information ABSTRACT: (−)-Epigallocatechin-3-gallate (EGCG) undergoes auto-oxidation at physiological pH and therefore may be poorly absorbed in the intestine. Fructooligosaccharides (FOS), comprising a group of 1-kestose, nystose, and 1 F -β fructofuranosyl-nystose, are fermentable by gut bacteria and converted mainly into lactate. This study was conducted to determine whether dietary FOS may help to increase the plasma concentration of EGCG in rats by preventing it from auto-oxidation. Rats consumed an assigned diet, either a 0.3% (w/w) EGCG diet or an EGCG diet with additional 1, 3, or 5% (w/w) FOS, for 2 weeks. The results showed that the plasma concentration of EGCG was 0.21 ± 0.05 μM for the EGCG alone group, and it was significantly higher at 0.65 ± 0.12 μM for the EGCG plus 5% FOS group. Treatments with FOS resulted in a dose-dependent increase in the cecal level of lactate and brought the cecal pH down, with an accompanying alteration in the abundance of Lactobacillus and Collinsella. Because EGCG concentrations in the cecal digesta of rats fed the FOS-containing diet maintained comparatively high levels, FOS likely contributed to the protection of EGCG from auto-oxidation. In conclusion, FOS reduced the pH of the lumen of the intestine, kept EGCG intact to a certain degree, and consequently allowed EGCG to be taken into the blood circulation from the intestine.

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Effects of stachyose on absorption and transportation of tea catechins in mice: possible role of Phase II metabolic enzymes and efflux transporters inhibition by stachyose

Cited by 7 publications

References 33 publications

Stachyose combined with tea polyphenols mitigated metabolic disorders in high fructose diet-fed mice as studied by GC-MS metabolomics approach

Stachyose combined with tea polyphenols mitigated metabolic disorders in high fructose diet-fed mice as studied by GC-MS metabolomics approach

Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

Fructooligosaccharides Increase in Plasma Concentration of (−)-Epigallocatechin-3-Gallate in Rats

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