Effects of static magnetic fields on the development and aging of<i>Caenorhabditis elegans</i>

Hung, Yao Ching; Lee, Jia Huey; Chen, Huang Meng; Huang, G. S.

doi:10.1242/jeb.039768

Cited by 19 publications

(12 citation statements)

References 43 publications

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“…In contrast, our data demonstrated that timing and rate of development from eggs to adults were delayed by embryonic exposure to 8.5 T SMF. One possible explanation for differences between our present work and previous findings is intensity and duration of exposure to magnetic fields [Hung et al, 2010]. Experimental variables such as sample insertion speed and gradient currents should be considered in future studies.…”

Section: Discussioncontrasting

confidence: 78%

“…Although clinical MR systems using SMFs up to 8 T have been considered a``non-significant risk'' to adult patients by the Center of Device and Radiological Health [FDA, 2003], a number of recent studies indicated that SMFs may affect early embryonic development. Exposure to 200 mT SMF was reported to shorten the lifespan of C. elegans, but their development rate was accelerated, and expression of genes associated with development and aging pathways such as clock (biological timing) abnormality-1 (clk-1), LIM domain family (lim-7), abnormal cell lineage-4 (lin-4), uncoordinated-3 (un-3), aging alteration-1 (age-1), and daf-2, was altered at the mRNA level [Hung et al, 2010]. In contrast, our data demonstrated that timing and rate of development from eggs to adults were delayed by embryonic exposure to 8.5 T SMF.…”

Section: Discussionmentioning

confidence: 99%

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Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Wang

Guo

et al. 2015

Bioelectromagnetics

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Understanding the effects of strong static magnetic fields (SMFs) on living organisms is significant in health risk assessment, but underlying mechanisms are largely unknown. In the present study, we determined developmental abnormalities induced by 8.5Tesla (T) SMFs in a well-established in vivo model organism, Caenorhabditis elegans (C. elegans). Exposure of C. elegans eggs to 8.5 T SMF resulted in a time-dependent lifespan decrease, whereas only slight changes were observed upon exposure to 5 T SMF. Although SMF exposure did not alter brood size, development rate and stages were significantly modified by 8.5 T SMF. Germ cell apoptosis dramatically increased upon exposure to 8.5 T SMF in adult worms, as confirmed by ced-3 and ced-4 mutants, and could be prevented by concurrent treatment with a free radical scavenger, dimethyl sulfoxide. Compared to wild-type worms, shorter lifespan and greater numbers of apoptotic cells were observed in abnormal methyl viologen sensitivity-1 (mev-1(kn1)) nematodes with increased sensitivity to oxidative damage. Furthermore, exposure to 8.5 T SMF increased expression of superoxide dismutase-3 (sod-3), which is thought to protect against oxidative stress. However, 8.5 T SMF had minimal effects on lifespans of daf-2 and daf-16 mutants, which have compromised insulin/IGF-1 (insulin-like growth factors-1) mediated signaling pathways; this finding was consistent with the expression of these genes in wild-type worms. Our results indicate that developmental toxicity induced by strong SMF in C. elegans is mediated by oxidative stress and may be regulated by the insulin-like receptor pathway.

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Section: Discussioncontrasting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Wang

Guo

et al. 2015

Bioelectromagnetics

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“…(Bowling 2007;Glass 2003;Hung, Lee, Chen, and Huang 2010;Pruchno, Wilson-Genderson, and Cartwright 2010;Pruchno, Wilson-Genderson, Rose, and Cartwright 2010) For example, Rowe and Kahn’s model of successful aging, (Rowe and Kahn 1997) one of the most widely accepted and applied models,(Dillaway and Byrnes 2009) views “better than average” aging as a combination of three components: avoiding disease and disability, high cognitive and physical function, and engagement with life. Recent models continue to support the multidimensional nature of this construct and have incorporated both objective and subjective dimensions in their definitions of successful aging.…”

Section: Introductionmentioning

confidence: 99%

Successful aging: Advancing the science of physical independence in older adults

Anton

Woods

Ashizawa

et al. 2015

Ageing Research Reviews

213

162

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The concept of ‘Successful Aging’ has long intrigued the scientific community. Despite this long-standing interest, a consensus definition has proven to be a difficult task, due to the inherent challenge involved in defining such a complex, multi-dimensional phenomenon. The lack of a clear set of defining characteristics for the construct of successful aging has made comparison of findings across studies difficult and has limited advances in aging research. The domain in which consensus on markers of successful aging is furthest developed is the domain of physical functioning. For example, walking speed appears to be an excellent surrogate marker of overall health and predicts the maintenance of physical independence, a cornerstone of successful aging. The purpose of the present article is to provide an overview and discussion of specific health conditions, behavioral factors, and biological mechanisms that mark declining mobility and physical function and promising interventions to counter these effects. With life expectancy continuing to increase in the United States and developed countries throughout the world, there is an increasing public health focus on the maintenance of physical independence among all older adults.

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“…Besides alternating magnetic fields, static magnetic fields also can affect the locomotion and lifespan in C. elegans. Hung et al reported reduced crawling speeds when worms were exposed to static magnetic fields [24] [25]. Investigations regarding the directional ability of worms in magnetic fields have been less conclusive.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the Effect of Static Magnetic Fields on <i>C. elegans</i> Using Microfluidics

Njus¹,

Feldmann²,

Brien³

et al. 2015

ABB

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In nature, several organisms possess a magnetic compass to navigate or migrate them to desired locations. It is thought that these organisms may use biogenic magnetic matter or light-sensitive photoreceptors to sense and orient themselves in magnetic fields. To unravel the underlying principles of magnetosensitivity and magnetoreception, previous experiments have been conducted on bacteria, vertebrates, crustaceans, and insects. In this study, the model organism, C. elegans, is used to test their response and sensitivity to static magnetic fields in the range of 5 milli Tesla to 120 milli Tesla. Single wild-type C. elegans are put in microfluidic channels and exposed to permanent magnets for five cycles of thirty-second time intervals. The worm movement is recorded and analyzed with custom software to calculate the average velocity and the percentage of turning and curling. Contrary to some published studies, our results did not show a significant difference compared to control experiments. This suggests that C. elegans may not sense static magnetic fields in the range of field strengths that we tested.

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Effects of static magnetic fields on the development and aging ofCaenorhabditis elegans

Abstract: SUMMARY

Cited by 19 publications

References 43 publications

Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Successful aging: Advancing the science of physical independence in older adults

Characterizing the Effect of Static Magnetic Fields on <i>C. elegans</i> Using Microfluidics

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Effects of static magnetic fields on the development and aging ofCaenorhabditis elegans

Abstract: SUMMARY

Cited by 19 publications

References 43 publications

Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans

Successful aging: Advancing the science of physical independence in older adults

Characterizing the Effect of Static Magnetic Fields on &lt;i&gt;C. elegans&lt;/i&gt; Using Microfluidics

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Characterizing the Effect of Static Magnetic Fields on <i>C. elegans</i> Using Microfluidics