Effects of statin therapy on glycemic control and insulin resistance: A systematic review and meta-analysis

Álvarez-Jimenez, Laura; Morales-Palomo, Félix; Moreno‐Cabañas, Alfonso; Ortega, Juan F.; Mora-Rodríguez, Ricardo

doi:10.1016/j.ejphar.2023.175672

Cited by 28 publications

(14 citation statements)

References 118 publications

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“…"Atorvastatin" had the highest frequency of occurrence (107), indicating that it was the most frequently used keyword,followed by "statins" (92 occurrences) and "insulin resistance" (79 occurrences). The nodes "atorvastatin", "simvastatin", "pravastatin", "statins", "rosuvastatin" and "pitavastatin" were relatively large, were located at the center of the map and were more densely connected to other nodes in comparison with other statin-related keywords, namely "fluvastatin", "lovastatin" and the class "HMG-CoA reductase inhibitor", Among the statin-related keywords, "atorvastatin" had the highest keyword occurrence, followed by simvastatin (72), pravastatin (70), rosuvastatin (51), pitavastatin (10), lovastatin (6) and fluvastatin (6). "HMG-CoA reductase inhibitor" had an occurrence frequency of five.…”

Section: Co-occurrence Analysis Of Abstractmentioning

confidence: 99%

“…Four themes (clusters) were recognized, and are represented by colors in Figure 4. The 8 nodes in the blue-colored cluster includes "atorvastatin", "rosuvastatin", "pitavastatin", "risk" (71 occurrences), "newonset diabetes mellitus" (10), "prediabetes" (7), "impaired fasting glucose" (6) and "insulin secretion" (6), which could represent the theme "heterogeneity" in the diabetogenic risk of different statins in different subgroup of patients. The 12 nodes in the red-colored cluster include "simvastatin", "pravastatin", "statins", "lovastatin", "fluvastatin", "HMG-CoA reductase inhibitor", "insulin sensitivity" (17 occurrences), "glucose-uptake" (10), "muscle" (7), "GLUT4" (5), and "mitochondrial dysfunction" (5), which could represent the theme "peripheral glucose uptake and insulin sensitivity" after statin treatment.…”

Section: Co-occurrence Analysis Of Abstractmentioning

confidence: 99%

“…The 12 nodes in the red-colored cluster include "simvastatin", "pravastatin", "statins", "lovastatin", "fluvastatin", "HMG-CoA reductase inhibitor", "insulin sensitivity" (17 occurrences), "glucose-uptake" (10), "muscle" (7), "GLUT4" (5), and "mitochondrial dysfunction" (5), which could represent the theme "peripheral glucose uptake and insulin sensitivity" after statin treatment. The 10 nodes in the green-colored cluster includes "metabolic syndrome" (32 occurrences), "inflammation" (28), "C-reactive protein" (19), "oxidative stress" (15), "glucose metabolism" (15), "liver" (9), "beta-cell function" (6), "adiponectin" (23), adipocytokines" (5) and "non-diabetic patients" (6). This could represent the theme "tissue inflammation and oxidative stress" which could be related to a metabolic condition, in particular diabetes.…”

Section: Co-occurrence Analysis Of Abstractmentioning

confidence: 99%

“…This could represent the theme "tissue inflammation and oxidative stress" which could be related to a metabolic condition, in particular diabetes. The 5 nodes in the yellow-colored cluster includes "insulin resistance" (79 occurrences), "adipose-tissue" (13), "skeletalmuscle" (13), "PPAR-gamma" (6) and "hepatic steatosis" (5). This could represent the theme "targeted tissues" involving liver, adipocytes and skeletal muscle in statin-associated NOD2 and insulin resistance.…”

Section: Co-occurrence Analysis Of Abstractmentioning

confidence: 99%

“…Based on a more recent systematic review and metaanalysis involving 67 randomized controlled trials enrolling a total of 25,481 individuals, statins minimally but significantly increase diabetic indexes in individuals with adequate or altered glycemic control. The diabetogenic effect of statins does not seem to be determined by the type or dosage of statin prescribed 6 . Studies have suggested that statins can increase insulin resistance while reducing insulin sensitivity and secretion from pancreatic β -cells 7, 8 .…”

Section: Introductionmentioning

confidence: 98%

See 4 more Smart Citations

Statin-associated new-onset diabetes mellitus and insulin resistance: a 30-year bibliometric study (1992-2022)

Kamisah,

Nordin,

Harafinova

et al. 2023

Biomed. Res. Ther.

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Statins are widely used lipid-lowering drugs that are relatively well-tolerated and have an established safety profile. However, statin therapy has been reported to increase the risk of developing new-onset type 2 diabetes mellitus (NOD2). Although this side effect is rare, research on this topic is still ongoing. This bibliometric study was performed to provide an overview of the dynamics of research on statin-associated NOD2 and insulin resistance from the initial report to the year 2022. Original articles related to statin-associated NOD2 and insulin resistance were selected and retrieved from the Web of Science database. A quantitative analysis of publication trends, the contributions of different countries and funding agencies, and the most highly cited articles were then tabulated. The citation networks and the co-occurrence analysis of keywords of the included articles were illustrated with VOSviewer. A total of 271 research articles were included and analysed. The years 2012 to 2016 were prolific in research on statin-associated NOD2 and insulin resistance, followed by a decreasing trend in publications on this topic in many countries, particularly from 2020 to 2021. However, researchers from South Korea and China seem to have had a continued interest in this research area and the trend in publications increased again in 2022. Based on this trend, it is predicted that the number of pertinent articles in the coming years will be maintained or will continue to rise. The co-occurrence analysis of keywords showed that ``atorvastatin'' occurred more often than other statins. Among the thematic areas of research on statin-associated NOD2 and insulin resistance that were identified in this study were ``heterogeneity'' , ``peripheral glucose uptake and insulin sensitivity'' , ``tissue inflammation and oxidative stress'' and ``targeted tissues'' . This is the first bibliometric study to predict the trends and provide an overview of the progress of research on statin-associated NOD2 and insulin resistance.

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Section: Co-occurrence Analysis Of Abstractmentioning

confidence: 99%