Effects of steroid hormones on muscle reinnervation after nerve crush in rabbit

Vita, Giuseppe; Dattola, R.; Girlanda, Paolo; Oteri, Giacomo; Presti, F.; Messina, C

doi:10.1016/0014-4886(83)90282-0

Cited by 46 publications

(26 citation statements)

References 13 publications

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“…Other neuroactive steroids exert promising neuroprotective effects. In several peripheral neuropathy models, testosterone (T) and its derivative, dihydrotestosterone (DHT), accelerate regeneration and functional recovery of nerves [24][25][26][27][28][29]. These steroids can also exert a control on the expression of some myelin proteins.…”

Section: Introductionmentioning

confidence: 99%

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

Roglio

Bianchi

Giatti

et al. 2007

Cell. Mol. Life Sci.

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Section: Introductionmentioning

confidence: 99%

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

Roglio

Bianchi

Giatti

et al. 2007

Cell. Mol. Life Sci.

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“…Vita et al (1983) examined the effects of a mixture of steroid derivatives with weak androgenic activity on muscle reinnervation after sciatic nerve crush in male rabbits. Thcy found a slight increase in nerve outgrowth distance, as well as a larger mean diameter of type 2c fibers within the extensor digitorum longus and soleus muscles.…”

Section: Introductionmentioning

confidence: 99%

Testosterone regulation of the regenerative properties of injured rat sciatic motor neurons

Kujawa

Jacob

Jones

1993

J of Neuroscience Research

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We have previously demonstrated that systemic administration of testosterone differentially regulates the regenerative properties of injured hamster facial motor neurons, which are androgen receptor-containing cranial motor neurons. In this investigation, the hypothesis that testosterone alters the regenerative properties of rat sciatic motor neurons, which are androgen receptor-containing spinal motor neurons, was tested using fast axonal transport of radioactively labeled proteins to assess sciatic nerve regeneration. Adult castrated male rats were subjected to crush axotomy of the sciatic nerve at the level of the gemelli tendons (mid-thigh). One-half of the axotomized animals received subcutaneous implants of testosterone propionate (TP), with the remainder of the animals sham implanted with blank capsules. The outgrowth distances of the leading axons were measured at 5, 6, 7, and 11 days postoperative. Linear regression analysis was accomplished, with the slope of the line representing the regeneration rate and the x-intercept the initial delay of sprout formation. Systemic administration of testosterone resulted in a 13% increase in the rate of regeneration, relative to the control, -TP group. Outgrowth distances were significantly increased in the +TP group only in the later stages of regeneration. However, TP did not shorten the delay in sprout formation in regenerating sciatic motor neurons, but instead produced a small prolongation in the delay time. This pattern of hormonal regulation of the regenerative properties of spinal motoneurons is similar to that previously found in cranial motoneurons. The prolongation of the initial delay may have been a factor in the lack of significant outgrowth distances during the early stages of regeneration.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…Androgens were also reported to hasten reinnervation of leg muscles after sciatic nerve lesion in rabbits (Vita et al, 1983). The site(s) and mechanism(s) whereby androgens influence nerve regeneration are not known at the present time.…”

Section: Discussionmentioning

confidence: 88%

Androgen receptor levels in cranial nerve nuclei and tongue muscles in rats

Yu¹,

McGinnis²

1986

J. Neurosci.

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Specific in vitro binding of 3H-methyltrienolone (R1881) was demonstrated in 100,000 x g supernatant (cytosol) of hypoglossal, facial, and cochlear nuclei and tongue muscles of adult rats. Binding sites in these cranial nerve nuclei and tongue muscles were of high affinity, limited capacity, with steroid specificity; and they were capable of translocation to the cell nuclei in viva Accordingly, an androgen receptor system with properties very much akin to the androgen receptors described in the forebrain limbic regions has been quantitatively demonstrated for the first time in brain stem nuclei. Because of its widespread presence in neurons of the brain stem and spinal cord, androgen receptors may have important roles in regulation of neuron physiology beyond the sphere of reproductive function, including mediating androgen effects on regeneration of the hypoglossal nerve reported previously.Neurons responsive to gonadal steroid hormones are most numerous and best known in the forebrain limbic regions such as the hypothalamus, preoptic-septal area, and amygdala. Much evidence has been gathered indicating that gonadal steroids affect the biochemistry (McEwen et al., 1979), electrical activities (Pfaff, 1980), and morphology (Cohen and Pfaff, 1981;Cohen et al., 1984) of neurons in these regions. Some of these effects are thought to be mediated via classical mechanisms of steroid hormone action involving activation of the genome in target cells by hormone-receptor complexes. Recently, it has been demonstrated that gonadal steroid-sensitive neurons are more widely spread. Radioautographic studies in several vertebrate classes have revealed that motor neurons in nuclei of cranial and spinal nerves, as well as neurons of sensory projection areas in the brain stem and spinal cord, concentrate significant amounts of radioactivity following in viva administration of 3H-steroids (Arnold et al., 1976;Breedlove and Arnold, 1980;Commins and Yahr, 1985;Keefer et al., 1973;Kelley, 1980;Kelley et al., 1975;Morrell et al., 1975Morrell et al., , 1982Sar and Stumpf, 1977; Sheridan and Weaker, 198 1, 1982 cause R 188 1 is stable to metabolic conversion and binds weakly to testosterone-estradiol binding globulin Raynaud, 1975, 1976;Doering and Leyra, 1984;Liao et al., 1973), its use was deemed more suitable than its naturally occurring counterparts. The present investigation demonstrates that cranial nerve nuclei and tongue muscles in the adult rat possess a receptor system with properties similar to the androgen receptors described in forebrain regions and limb muscles. Materials and Methods Animals and materialsSprague-Dawley rats (200-220 gm) of both sexes were purchased from Charles River Breeding Laboratories (Wilmington, MA). All rats were either orchidectomized or ovariectomized bilaterally under light ether anesthesia 2-3 d before being killed. 3H-R 188 1 (specific activity, 87 Ci/ mmol) was purchased from New England Nuclear (Boston, MA). Unlabeled steroids and other chemicals were from Sigma Chemical Co.(St. Louis, MO)...

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Effects of steroid hormones on muscle reinnervation after nerve crush in rabbit

Cited by 46 publications

References 13 publications

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy

Testosterone regulation of the regenerative properties of injured rat sciatic motor neurons

Androgen receptor levels in cranial nerve nuclei and tongue muscles in rats

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