Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: An ultrasonographic study

Karadaş, Ömer; Omaç, Özlem Köroğlu; Tok, Fatih; Özgül, Ahmet; Odabaşı, Zeki

doi:10.1016/j.jns.2012.01.023

Cited by 18 publications

(15 citation statements)

References 22 publications

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“…Furthermore, its effect in treating diseases has been revealed in recent years. For example, injection of 4 mL 1% procaine HCl in median nerves improves the clinical and electrophysiological evaluations of carpal tunnel syndrome patients (Karadaş et al ., 2012a, 2012b). Procaine is a potential agent for treating bladder cancer treatment for its regulation of different cell apoptotic pathways (Sun et al ., 2012) and is a suppressor in human nasopharyngeal carcinoma cell line CNE-2Z (Zhou et al ., 2007).…”

Section: Introductionmentioning

confidence: 99%

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Yan

Lan

et al. 2016

Biomol Ther (Seoul)

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Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model was induced by sciatic nerve chronic compression injury (CCI) and behavior tests were performed to analyze the pain behaviors upon mechanical, thermal and cold stimulations. Spinal expression of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was detected by qRT-PCR and western blot. JAK2 was also overexpressed in procaine treated model rats for behavior tests. Results showed that procaine pretreatment improved the pain behaviors of model rats upon mechanical, thermal and cold stimulations, with the best effect occurring on the 15th day post model construction (p<0.05). Procaine also inhibited JAK2 and STAT3 expression in both mRNA (p<0.05) and protein levels. Overexpression of JAK2 increased STAT3 level and reversed the improvement effects of procaine in pain behaviors (p<0.01). These findings indicate that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling.

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Section: Introductionmentioning

confidence: 99%

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Yan

Lan

et al. 2016

Biomol Ther (Seoul)

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“…18,19 Additionally, corticosteroid phonophoresis, steroids, and procaine hydrochloride injection treatments in patients with CTS have improved electrophysiological parameters. 20,21 Improved electrophysiological parameters with pulsed SWD treatment reported herein suggest that this treatment might also have thermal effects. Pulsed SWD can increase tissue temperature, depending on the dose administered.…”

Section: Discussionmentioning

confidence: 75%

Comparison of the Short-Term Effectiveness of Short-Wave Diathermy Treatment in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial

et al. 2014

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Carpal tunnel syndrome (CTS) is one of the most common entrapment neuropathies caused by compression of the median nerve within the carpal tunnel in the wrist. 1 The diagnosis is based on medical history, clinical and physical examination findings, as well as electrophysiological confirmation. Available conservative treatments include wrist-resting splints, local steroid injections, non-steroidal antiinflammatory drugs (NSAIDs), physical therapy, diuretics, vitamin B6, and activity modification. However, the efficacy of these treatments remains controversial. 2,3Short-wave diathermy (SWD) is a form of electromagnetic therapy used at a frequency of 27.12 MHz in continuous or pulsed forms. Molecular distortion occurs due to the movement of ions in the electromagnetic field, and heat is generated in the deep tissues with induced eddy currents. 4 In addition to the effects of SWD on the tissues, healing is stimulated with increased vascular circulation and pain threshold, and decreased pain and chronic inflammation. 5 It is thought that these effects cannot be explained solely by the heating effect, and some of the therapeutic effects of SWD treatment Objectives: This study aims to compare the effects of pulsed and continuous short wave diathermy (SWD) treatment in carpal tunnel syndrome. Patients and methods: This double-blind, randomized controlled trial included 30 patients (55 wrists) diagnosed with mild or moderate carpal tunnel syndrome. Patients were randomized into three groups and administered splinting and one of the following treatments: group 1: continuous SWD, group 2: pulsed SWD, and group 3: placebo SWD. The treatment was applied five days a week for 15 sessions. Patients were evaluated by the Tinel's test, Phalen's and reverse Phalen's maneuvers, carpal compression test, the Boston Carpal Tunnel Questionnaire (BCTQ: includes 2 parts, namely the symptom severity scale and functional status scale), and a visual analog scale. Median motor distal latency, median sensory distal latency, and nerve conduction velocity were measured. Electrophysiological findings, clinical tests, and scales were evaluated at the beginning and end of the therapy. Results: A significant difference was observed in Phalen's maneuver positivity in the pulsed SWD group (p<0.05). Visual analog scale, BCTQfunctional status scale, BCTQ-symptom severity scale, median nerve motor and sensory latencies, and sensory nerve conduction velocity values were improved in both continuous and pulsed SWD groups (p<0.05). The placebo group also showed improved BCTQ-functional status scale and median nerve motor distal latency (p<0.05). BCTQ-symptom severity scale improved more in the continuous SWD group than the other groups (p<0.01), and improved median nerve sensory distal latency and nerve conduction velocity parameters were observed in both SWD groups than the control group (p<0.01). Conclusion: Continuous and pulsed SWD therapies supported with splinting were effective for improving pain, hand function, and electrophysiological findings. In ...

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“…PHCl is one most effective local anesthetics that have the highest pKa level among the local anesthetics [12]. Besides procaine has been long employed as a pharmacological agent in the life sciences and clinical therapeutic studies [13].…”

Section: Resultsmentioning

confidence: 99%

Investigation of radiosensitivity of gamma irradiated procaine hydrochloride in the solid state

Osmanoğlu

2017

El-Cezeri Fen Ve Mühendislik Dergisi

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Dosimetric properties of gamma-irradiated procaine hydrochloride were investigated at room temperature by Electron Paramagnetic Resonance technique. No signal was obtained on the non-irradiated samples; however significant signals were obtained from the samples irradiated with gamma at certain doses. Mathematical functions and correlation coefficients were calculated determining the relation between the increasing radiation doses on the signal intensities of the sample. The free radicals were appeared to be stable at room temperature for more than 200 days.

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Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: An ultrasonographic study

Cited by 18 publications

References 22 publications

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Procaine Attenuates Pain Behaviors of Neuropathic Pain Model Rats Possibly via Inhibiting JAK2/STAT3

Comparison of the Short-Term Effectiveness of Short-Wave Diathermy Treatment in Patients With Carpal Tunnel Syndrome: A Randomized Controlled Trial

Investigation of radiosensitivity of gamma irradiated procaine hydrochloride in the solid state

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