2007
DOI: 10.1002/cii.336
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Effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation

Abstract: The present study examined the effects of steroids and lubricants on electrical impedance and tissue response following cochlear implantation in animal models. Guinea pigs were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone, sodium hyaluronate or saline. Cats were implanted following either no treatment, or intrascalar injection with dexamethasone, triamcinolone or a mixture of triamcinolone with sodium hyaluronate. In guinea pigs, impedance changes and intr… Show more

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Cited by 25 publications
(29 citation statements)
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“…However, the studies cannot be compared directly as both the drug delivery and implant method differed which may result in an altered inflammatory response. A second observation of relevance is the finding by Huang et al [2007] that coating a cochlear electrode with Healon/triamcinolone delayed, but ultimately did not prevent an increase in electrode impedance and the formation of a fibrous tissue sheath around the cochlear implant electrode. If the same were true following round window delivery of steroids, and if we assume that an increased fibrous reaction may damage the residual hearing [Choi and Oghalai, 2005], it is possible that the hearing preservation that we observed may turn out to be temporary.…”
Section: Discussionmentioning
confidence: 99%
“…However, the studies cannot be compared directly as both the drug delivery and implant method differed which may result in an altered inflammatory response. A second observation of relevance is the finding by Huang et al [2007] that coating a cochlear electrode with Healon/triamcinolone delayed, but ultimately did not prevent an increase in electrode impedance and the formation of a fibrous tissue sheath around the cochlear implant electrode. If the same were true following round window delivery of steroids, and if we assume that an increased fibrous reaction may damage the residual hearing [Choi and Oghalai, 2005], it is possible that the hearing preservation that we observed may turn out to be temporary.…”
Section: Discussionmentioning
confidence: 99%
“…Similarly, while it has been observed that a single application of steroids may lead to lasting reductions in impedance in the clinic [27,68], there is contrary experimental evidence on the stability of electrode impedance. When the steroid triamcinolone was irrigated through the basal turn of the cat immediately prior to cochlear implantation, Huang et al [69] found that electrode impedance remained low for 2 months, but then increased to levels similar to control groups. As when considering the progression of hearing loss, the method of drug delivery might influence the duration of treatment required to achieve a lasting protective effect.…”
Section: Discussionmentioning
confidence: 99%
“…As when considering the progression of hearing loss, the method of drug delivery might influence the duration of treatment required to achieve a lasting protective effect. The method of drug delivery of Huang et al [69] was similar to that applied in the clinical trials on electrode impedance, and involved the gentle irrigation of the basal turn of the cochlea with triamcinolone prior to electrode insertion. The irrigation may itself cause some trauma (and would be contraindicated if hearing preservation were an aim), which might lead to a more extensive cochlear tissue response or an inflammatory reaction.…”
Section: Discussionmentioning
confidence: 99%
“…Among others, inflammatory and immunological responses of the body to implantation with subsequent connective and bone tissue growth have been suggested. Therefore, inflammation-suppressing substances, such as glucocorticoids, have been applied locally during implantation [2][3][4]14] . The impact of glucocorticoids on hearing was first published in the late seventies [15] .…”
Section: Introductionmentioning
confidence: 99%