Effects of Stimulation of Frontal Cortex and Hippocampus on Behaviour in the Monkey

Aspects of the delayed alternation deficit produced by electrical stimulation in monkeys

“…The present study confirms and extends the previous results of Stamm (1961) and Weiskrantz, Mihailovic, & Gross (1960, 1962. However, the finding that frontal stimulation disrupted an overtrained alternation habit in a WGTA and also, under certain conditions, in an automatic apparatus seems incompatible with the view that such stimulation affects the "learning" but not the "memory" of this habit.…”

“…Four immature rhesus monkeys were implanted with Delgado-type cortical plate electrodes as described by stamm (1961) and Weiskrantz et al (1962). Three pairs of electrodes were placed, bilaterally, on the banks of sulcus principalis.…”

“…(Stamm, 1961;Weiskrantz, Mihailovic, & Gross, 1960, 1962Briese & Olds, 1964;Cianci, 1965). Two of these studies differed in their methods and conclusions.…”

Evidence for dissociation of impairment on auditory discrimination and delayed response following lateral frontal lesions in monkeys

“…Weiskrantz,Mihailovic,and Gross (38,39) a severe deficit on delayed-alternation but not on auditory-discrimination performance when they stimulated a region of sulcus principalis. However, when they stimulated a part of the arcuate sulcus they obtained no impairment on either task.…”

The Hippocampus as a Cognitive Map

“…With parameters specifically chosen to avoid at least overt behavioural seizures, or with spreading depression confined to the hippocampus, a different picture emerges. No disruption was seen in the performance of go-no-go discrimination, learning set and delayed alternation (Weiskrantz, Mihailovic, and Gross 1962), nor in a position habit (Olds and Olds 1961), nor in a T-maze brightness discrimination (Grossman and Mountford 1964), nor in lever-press avoidance (Margules and Stein 1968).…”