Effects of Stimulation of Nerve Fibers on the Contractile Activity of Tracheobronchial Lymph Node Capsule Smooth Muscles

Lobov, G. I.; Pan’kova, M. N.

doi:10.1007/s11055-013-9801-5

Cited by 2 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, the smooth muscles in the capsule are probably a specific structure that produces lymph flow in the LN. In fact, physiological studies have shown the contractility of the LN's capsule [23][24][25]. The capsule of the LNs was observed to be thick on the afferent side but loose on the efferent side, consistent with previous studies [13,18].…”

Section: Discussionsupporting

confidence: 89%

Distribution of Contractile Structures in a Mouse and Human Lymph Node Associated with Lymph Flow

Ishi,

Omotehara,

et al. 2023

Acta Histochem. Cytochem

View full text Add to dashboard Cite

Lymph nodes have contractile structures, but their distribution in a lymph node has been less considered in terms of facilitation of lymph flow. Axillary, inguinal, and mesenteric lymph nodes were collected from mice and human cadavers, and their sections were immunostained for alpha-smooth muscle actin (αSMA) and high molecular weight caldesmon (Hcaldesmon). The αSMA-positive cells were localized in the capsule beneath the ceiling epithelium on the afferent side in both mice and humans. We found an additional layer of the αSMA-positive cells in the human lymph node, surrounding the inner layer perpendicularly. H-caldesmon was expressed only in these cells of the outer layer. In some human lymph nodes highly containing fat tissue in the medulla, the capsule disappeared on the efferent side, resulting in a disrupted sinusoidal lymph pathway. These findings suggest that human lymph nodes have additional smooth muscles in the outer region of the capsule to facilitate lymph flow. The αSMA-positive cells in the outer and inner layers of human lymph nodes probably have different functions in contraction. The presence of lipomatosis in a human lymph node will reduce its contribution to the lymph flow.

show abstract

Section: Discussionsupporting

confidence: 89%

Distribution of Contractile Structures in a Mouse and Human Lymph Node Associated with Lymph Flow

Ishi,

Omotehara,

et al. 2023

Acta Histochem. Cytochem

View full text Add to dashboard Cite

show abstract

“…В физиологических условиях вегетативная нерв ная система оказывает слабое влияние на транспорт лимфы лимфатическими сосудами, однако при силь ном возбуждении симпатической нервной системы зарегистрированы выраженные реакции лимфати ческих сосудов, проявляющиеся в многократном учащении фазных сокращений и резком повыше нии тонуса. Есть основания полагать, что в стрес совых ситуациях подобные реакции способствуют быстрому перемещению лимфы и поступлению ее в крово ток, что может приводить к увеличению объема циркулирующей крови и способствовать повышению артериального давления в стрессовой ситуации [20].…”

Section: регуляция транспортной функции лимфатических сосудовunclassified

The role of the lymphatic system in the homeostasis of the interstitial fluid in the lung and pleural liquid

Lobov¹

2019

Regional blood circulation and microcirculation

Self Cite

View full text Add to dashboard Cite

Accomplishments in the identifcation of lymphatic endothelial cells and the ability to differentiate them from the endothelial cells of blood vessels have contributed to progress in recent decades in studying the role of the lymphatic system in the body. Preclinical and clinical studies of the last decade have shown that changes in the lymphatic vascular network are observed in almost all lung diseases. At the same time, it remains unclear whether the lymphatic vessels and lung nodes are being part of the overall process of lung remodeling or they make a defnite contribution to the pathogenesis of diseases of the respiratory system. This review presents current data on the morphology and physiology of lymphatic vessels and nodes, their role in the regulation of interstitial ﬂuid homeostasis, lipid transportation and immune responses as well as describes the mechanisms of regulation of the transport function of lymphatic vessels. Data on the role of the lymphatic system of the lungs in the exchange of ﬂuid in the interstitial space of the lungs are presented in the review. The results of studies of the last two decades on the formation and reabsorption of pleural ﬂuid and the role of various lymphatic networks in regulating its volume are described. Finally, modern ideas on the mechanisms of pulmonary edema are outlined and important questions of the lymphatic biology of the respiratory system are identifed, still remaining unanswered today.

show abstract

Effects of Stimulation of Nerve Fibers on the Contractile Activity of Tracheobronchial Lymph Node Capsule Smooth Muscles

Cited by 2 publications

References 16 publications

Distribution of Contractile Structures in a Mouse and Human Lymph Node Associated with Lymph Flow

Distribution of Contractile Structures in a Mouse and Human Lymph Node Associated with Lymph Flow

The role of the lymphatic system in the homeostasis of the interstitial fluid in the lung and pleural liquid

Contact Info

Product

Resources

About