Effects of stimulus female on sexual behavior of male rats given olfactory tubercle and corticomedial amygdaloid lesions

Perkins, Mike; Perkins, Mary N.; Hitt, John C.

doi:10.1016/0031-9384(80)90112-2

Cited by 12 publications

(3 citation statements)

References 30 publications

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“…The olfactory tubercle also receives a major DA projection from the VTA (Roth, Wulf, & Deutsch, 1987). Although electrolytic lesions of the olfactory tubercle do not affect copulatory behavior in male rats (Perkins, Perkins, & Hitt, 1980), it would be important to examine whether DA antagonists or 6-OHDA lesions in this structure affect measures of anticipatory sexual behavior.…”

Section: Discussionmentioning

confidence: 99%

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

Pfaus¹,

Phillips²

1991

Behavioral Neuroscience

284

163

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The ability of dopamine (DA) receptor antagonists to disrupt anticipatory and consummatory measures of sexual behavior displayed by male rats in bilevel chambers was investigated. In Experiment 1, systemic administration of haloperidol, pimozide, and the D1 antagonist SCH 23390 reduced the number of anticipatory level changes (LC) displayed during a 5-min period before the introduction of a sexually receptive female, increased the mount and intromission latencies (ML and IL), and decreased the number of intromissions before ejaculation (NI) and the total number of ejaculations (NE). The dosages of these drugs required to reduce the LC were lower than those required to increase the ML or IL. Clozapine and the D2 antagonist sulpiride reduced the LC and increased the IL at comparable dosages, although neither drug affected the NI or NE. High dosages of haloperidol, pimozide, and clozapine delayed or abolished level changing and the initiation of copulation. In Experiment 2, bilateral infusions of haloperidol into the nucleus accumbens reduced the LC but did not affect consummatory measures of copulation, whereas bilateral infusions into the dorsal striatum increased the NE. Midline infusions of haloperidol to the medial preoptic area (MPOA) produced nearly all the effects of systemic administration, including a reduced LC, increased ML and IL, a decreased NI, and a decreased NE. These results indicate that both anticipatory and consummatory measures of sexual behavior were disrupted by DA receptor antagonists; however, the measure of anticipatory sexual behavior was more sensitive to disruption than consummatory measures of copulation. DA in the nucleus accumbens and MPOA may be involved in the control of anticipatory sexual behavior, whereas in the MPOA it may also be involved in the initiation of copulation and copulatory rate.

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Section: Discussionmentioning

confidence: 99%

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

Pfaus¹,

Phillips²

1991

Behavioral Neuroscience

284

163

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“…Stimulation of the mPO-AM (the prBNST or pdMAmg) can promote copulatory behavior in males and females and/or induce surges of luteinizing hormone and ovulation in females (Darner, 1976;Emery and Sachs, 1976;Taleisnik, 1978, 1980;Chozick, 1986). Lesions involving the mPO-AM impair copulatory behavior in males (Emery and Sachs, 1976;Valcourt and Sachs, 1979;Lehman et al, 1980;Perkins et al, 1980;Lehman and Winans, 1982) and increase the number of intromissions preceding ejaculation and prolongation of ejaculatory latency, intromission intervals, and postejaculatory refractory period (the penile reflex is not affected; Valcourt and Sachs, 1979). Regions included in the mPO-AM are closely interconnected (Weller and Smith, 1982;de Olmos et al, 1985;Swanson, 1986, 1988) and are regarded as a functional complex serving reproductive functions in both sexes.…”

Section: Medial Preopticoamygdaloid Neuronal Arcmentioning

confidence: 99%

Neuronal aromatase expression in preoptic, strial, and amygdaloid regions during late prenatal and early postnatal development in the rat

Shinoda

Nagano

Osawa

1994

J of Comparative Neurology

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Brain aromatase has been considered to be an important clue in elucidating the actions of androgen on brain sexual differentiation. Using highly specific anti-P450arom antiserum, the regional and subcellular distributions were immunohistochemically evaluated in the preoptic, strial, and amygdaloid regions of developing rat brains. Aromatase-immunoreactive (AROM-I) neurons were classified into three groups. The first, in which immunostaining occurs only during certain pre- or neonatal days (E16-P2), included the anterior medial preoptic nucleus, the periventricular preoptic nucleus, neurons associated with the strial part of the preoptic area, and the rostral portion of the medial preoptic nucleus. The second is a striking AROM-I cell group in the "medial preopticoamygdaloid neuronal arc," which extends from the medial preoptic nucleus to the principal nucleus of the bed nucleus of the stria terminalis and the posterodorsal part of the medial amygdaloid nucleus. The AROM-I neurons appeared by E16, reaching a peak in staining intensity between E18 and P2 and diminishing after the perinatal stage. After P14, a third group of AROM-I neurons emerged in the lateral septal nucleus, the oval nucleus of the bed nucleus of the stria terminalis, and the central amygdaloid nucleus. The second group was thought to be the major aromatization center in developing rat brains, while the center might partly shift to the third group of neurons after the late infantile stage. The distribution and developmental patterns were basically similar in males and females, suggesting that the neonatally prominent aromatase is not induced by male-specific androgen surges occurring around birth. On immunoelectron microscopy, subneuronal aromatase was predominantly localized on the nuclear membrane and endoplasmic reticulum, which appeared to be appropriate for the efficient conversion of androgen into estrogen just prior to binding to the nuclear receptors.

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“…Stimulation of the mPO-AM (the prBNST or pdMAmg) can promote copulatory behavior in males and females and/or induce surges of luteinizing hormone and ovulation in females [150][151][152][153]. Lesions involving the mPO-AM impair copulatory behavior in males [154][155][156][157]: increase in the number of intromissions preceding ejaculation, and prolongation of ejaculatory latency, intromission intervals and postejaculatory refractory period (the penile reflex is not affected) [154]. Regions included in the mPO-AM are closely interconnected [147,[158][159][160] and are regarded as a functional complex serving reproductive functions in both sexes.…”

Section: B Three Groups Of Aromatase-containing Neuronsmentioning

confidence: 99%

Brain Aromatization and Its Associated Structures.

Shinoda

1994

Endocr J

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Effects of stimulus female on sexual behavior of male rats given olfactory tubercle and corticomedial amygdaloid lesions

Cited by 12 publications

References 30 publications

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat.

Neuronal aromatase expression in preoptic, strial, and amygdaloid regions during late prenatal and early postnatal development in the rat

Brain Aromatization and Its Associated Structures.

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