Effects of stirring rate on morphology of aqueous RAFT emulsion PISA-derived block copolymer nanoparticles

Kim, Hyun Jin; Ishizuka, Fumi; Li, Jiang; Kuchel, Rhiannon P.; Chatani, Shunsuke; Niino, Hiroshi; Zetterlund, Per B.

doi:10.1039/d3py01318a

Polym. Chem.

2024

DOI: 10.1039/d3py01318a

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Effects of stirring rate on morphology of aqueous RAFT emulsion PISA-derived block copolymer nanoparticles

Hyun Jin Kim,

Fumi Ishizuka,

Jiang Li

et al.

Abstract: The influence of stirring rate on nanoparticle morphology in aqueous RAFT emulsion PISA has been investigated using the macroRAFT agents poly(poly(ethylene)glycol methyl ether acrylate)-TTC and poly(poly(ethylene glycol) methyl ether methacrylate)-TTC...

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Cited by 2 publications

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Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

Belluati,

Bloch,

Koynov

et al. 2024

Advanced Biology

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This study investigates the formation and properties of vesicles produced via biocatalytic Polymerization‐Induced Self‐Assembly (bioPISA) as artificial cells. Methods for achieving size uniformity, including gentle centrifugation and sucrose gradient centrifugation, are explored, and the effects of stirring speed on vesicle morphology is investigated. The internal structure of the vesicles, characterized by a polymer‐rich matrix, is analyzed using fluorescence correlation spectroscopy (FCS). Additionally, the feasibility of loading macromolecules into pre‐formed vesicles is demonstrated using electroporation, and a fluorescent protein as well as enzymes for a cascade reaction were sucesfully incorporated into the fully assembled polymersomes. These findings provide a foundation for developing enzyme‐synthesized polymeric vesicles with controlled morphologies for various applications, e.g., in synthetic biology.

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Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

Belluati,

Bloch,

Koynov

et al. 2024

Advanced Biology

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Peculiar Behavior of Methyl Methacrylate Emulsion Polymerization‐Induced Self‐Assembly Mediated by RAFT Using Poly(Methacrylic Acid) Macromolecular Chain Transfer Agent

Sun,

Wang,

Dugas

et al. 2024

Macromol. Rapid Commun.

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Reversible addition‐fragmentation chain transfer (RAFT) emulsion polymerization of methyl methacrylate (MMA) is successfully performed in water in the presence of a poly(methacrylic acid) (PMAA) macromolecular chain transfer agent (macroCTA) leading to the formation of self‐stabilized PMAA‐b‐PMMA amphiphilic block copolymer particles. At pH = 3.7, the reactions are well‐controlled with narrow molar mass distributions. Increasing the initial pH, particularly above 5.6, results in a partial loss of reactivity of the PMAA macroCTA. The effect of the degree of polymerization (DPn) of the PMMA block, the solids content, the nature of the hydrophobic segment and the pH on the morphology of the obtained diblock copolymer particles is then investigated. Worm‐like micelles are formed for a DPn of PMMA of 20 (PMMA20), while “onion‐like” particles and spherical vesicles are obtained for PMMA30 and PMMA50, respectively. In contrast, spherical particles are obtained for the DPns higher than 150. This unusual evolution of particle morphologies upon increasing the DPn of the PMMA block seems to be related to hydrogen bonds between hydrophilic MAA and hydrophobic MMA units.This article is protected by copyright. All rights reserved

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Effects of stirring rate on morphology of aqueous RAFT emulsion PISA-derived block copolymer nanoparticles

Abstract: The influence of stirring rate on nanoparticle morphology in aqueous RAFT emulsion PISA has been investigated using the macroRAFT agents poly(poly(ethylene)glycol methyl ether acrylate)-TTC and poly(poly(ethylene glycol) methyl ether methacrylate)-TTC...

Cited by 2 publications

References 45 publications

Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

Characterization and Optimization of Vesicle Properties in bioPISA: from Size Distribution to Post‐Assembly Loading

Peculiar Behavior of Methyl Methacrylate Emulsion Polymerization‐Induced Self‐Assembly Mediated by RAFT Using Poly(Methacrylic Acid) Macromolecular Chain Transfer Agent

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