Effects of Storage Time and Temperature on Antioxidants in Juice from Momordica charantia L. and Momordica charantia L. var. abbreviata Ser.

Lin, Yung‐Sheng; Wen-ying, Huang; Ho, Pang-Yen; Hu, Shiou-Yih; Lin, Yi-Cheng; Chen, Cheng-You; Chang, Moo Ung; Huang, Shu‐Ling

doi:10.3390/molecules25163614

Cited by 16 publications

(10 citation statements)

References 40 publications

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“…A published protocol [36,37] was employed with some modifications. In brief, 100 μL of 2 mM PBS buffer (pH 6.6), 100 μL of 1% potassium ferricyanide (K 3 Fe(CN) 6 ), and 100 μL of the by-product extract were evenly mixed in a 50 °C water bath for 20 minutes.…”

Section: Reductive Capacity Testmentioning

confidence: 99%

Antioxidation and Tyrosinase Inhibitory Ability of Coffee Pulp Extract by Ethanol

Chen

Shih

Lin

et al. 2021

Journal of Chemistry

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Background. Following petroleum, coffee is the second most commonly traded commodity globally. It is also a popular good with economic value, as well as value in terms of leisure and culture. However, coffee processing generates a large amount of waste, resulting in environmental concerns. Therefore, in this study, ethanol was used to extract coffee waste (coffee pulp). High-performance liquid chromatography was conducted to examine the caffeine content and chlorogenic acid content, and the antioxidant capacity (i.e., the total phenolic content, total flavonoid content, DPPH-free radical scavenging capacity, ABTS-free radical scavenging capacity, and reductive capacity) and the tyrosinase inhibition capacity of the coffee pulp extracted using ethanol were comprehensively evaluated. Results. The results showed that the coffee pulp extract obtained using 70% ethanol had the highest tyrosinase inhibition capacity, whereas that obtained using 50% ethanol had the most satisfactory antioxidant capacity (total phenolic content, total flavonoid content, DPPH-free radical scavenging capacity, ABTS-free radical scavenging capacity, and reductive capacity). Conclusion. The results revealed that coffee pulp has superior antioxidant capacity and tyrosinase inhibition capacity when extracted by ethanol. Increasing the economic value of coffee pulp can solve the environmental concerns caused by coffee waste.

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Section: Reductive Capacity Testmentioning

confidence: 99%

Antioxidation and Tyrosinase Inhibitory Ability of Coffee Pulp Extract by Ethanol

Chen

Shih

Lin

et al. 2021

Journal of Chemistry

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“…A major disadvantage of using plant material is the high variability in chemical composition and antioxidant properties, which depends not only on the changing environmental conditions, but also on the time of harvest, as well as storage and transport conditions [20,[80][81][82]. If we consider polyphenolic fractions as a source of antioxidants in the skin layers, it is important to estimate "competition" and "enhancer" properties of chemicals [15,16].…”

Section: Discussionmentioning

confidence: 99%

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study

et al. 2021

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Polyphenolic compounds—mangiferin and hesperidin—are, among others, the most important secondary metabolites of African shrub Cyclopia sp. (honeybush). The aim of this study was to compare the percutaneous absorption of mangiferin and hesperidin from solutions (water, ethanol 50%, (v/v)) and extracts obtained from green and fermented honeybush (water, ethanol 50%, (v/v)). Research was performed with the Bronaugh cells, on human dorsal skin. The mangiferin and hesperidin distributions in skin layers (stratum corneum, epidermis, and dermis) and in acceptor fluid (in every 2, 4, 6, and 24 h) were evaluated by HPLC–Photodiode Array Coulometric and Coulometric Electrochemical Array Detection. The transdermal distribution of hesperidin was also demonstrated by fluorescence microscopy. Results indicated that mangiferin and hesperidin were able to cross the stratum corneum and penetrate into the epidermis and dermis. An advantage of hesperidin penetration into the skin from the water over ethanol solution was observed (451.02 ± 14.50 vs. 357.39 ± 4.51 ng/cm2), as well as in the mangiferin study (127.56 ± 9.49 vs. 97.23 ± 2.92 ng/cm2). Furthermore, mangiferin penetration was more evident from nonfermented honeybush ethanol extract (189.85 ± 4.11 ng/cm2) than from solutions. The permeation of mangiferin and hesperidin through the skin to the acceptor fluid was observed regardless of whether the solution or the honeybush extract was applied. The highest ability to permeate the skin was demonstrated for the water solution of hesperidin (250.92 ± 16.01 ng/cm2), while the hesperidin occurring in the extracts permeated in a very low capacity. Mangiferin from nonfermented honeybush ethanol extract had the highest ability to permeate to the acceptor fluid within 24 h (152.36 ± 8.57 ng/cm2).

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“…The favorable effects of bitter gourd come from chemical components including cucurbitane-type triterpenoids, cucurbitane-type triterpene glycoside, phenolic acids, flavonoids, essential oils, fatty acids, amino acids, sterols, saponin constituents, and proteins. The pulp of this plant has a higher antioxidant activity than that of the seeds, which may be attributed to the different extents of phenolic acids and flavonoids [ 102 ]. Current studies have confirmed that bitter gourd has the therapeutic potential of lowering blood sugar, and lowering blood lipids, as well as anti-inflammatory, antioxidant, and anti-carcinogenic effects [ 103 , 104 , 105 ].…”

Section: Momordica Charantia Lmentioning

confidence: 99%

“…As a rule, immature bitter melon with darker green skin is more bitter, while bitter melon with lighter skin is less bitter. Furthermore, WBM has much higher saponins than bitter melon [ 102 ].…”

Section: Momordica Charantia L Varmentioning

confidence: 99%

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

Kung

Lin

2021

IJMS

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Neuroinflammation and abnormal mitochondrial function are related to the cause of aging, neurodegeneration, and neurotrauma. The activation of nuclear factor κB (NF-κB), exaggerating these two pathologies, underlies the pathogenesis for the aforementioned injuries and diseases in the central nervous system (CNS). CDGSH iron-sulfur domain 2 (CISD2) belongs to the human NEET protein family with the [2Fe-2S] cluster. CISD2 has been verified as an NFκB antagonist through the association with peroxisome proliferator-activated receptor-β (PPAR-β). This protective protein can be attenuated under circumstances of CNS injuries and diseases, thereby causing NFκB activation and exaggerating NFκB-provoked neuroinflammation and abnormal mitochondrial function. Consequently, CISD2-elevating plans of action provide pathways in the management of various disease categories. Various bioactive molecules derived from plants exert protective anti-oxidative and anti-inflammatory effects and serve as natural antioxidants, such as conjugated fatty acids and phenolic compounds. Herein, we have summarized pharmacological characters of the two phytochemicals, namely, alpha-eleostearic acid (α-ESA), an isomer of conjugated linolenic acids derived from wild bitter melon (Momordica charantia L. var. abbreviata Ser.), and curcumin, a polyphenol derived from rhizomes of Curcuma longa L. In this review, the unique function of the CISD2-elevating effect of α-ESA and curcumin are particularly emphasized, and these natural compounds are expected to serve as a potential therapeutic target for CNS injuries and diseases.

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Effects of Storage Time and Temperature on Antioxidants in Juice from Momordica charantia L. and Momordica charantia L. var. abbreviata Ser.

Cited by 16 publications

References 40 publications

Antioxidation and Tyrosinase Inhibitory Ability of Coffee Pulp Extract by Ethanol

Antioxidation and Tyrosinase Inhibitory Ability of Coffee Pulp Extract by Ethanol

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts (Cyclopia sp.)—A Comparison Ex Vivo Study

Beneficial Impacts of Alpha-Eleostearic Acid from Wild Bitter Melon and Curcumin on Promotion of CDGSH Iron-Sulfur Domain 2: Therapeutic Roles in CNS Injuries and Diseases

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