Effects of Strength Training on Muscle Hypertrophy and Muscle Cell Disruption in Older Men

Hurley, Ben F.; Redmond, R. A.; Pratley, Richard E.; Treuth, Margarita S.; Rogers, M. A.; Goldberg, A. P.

doi:10.1055/s-2007-973024

Cited by 100 publications

(66 citation statements)

References 6 publications

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“…Thus, previous studies reported that elderly orienteer runners had SDH, CS and 3-hydroxy-acyl-CoA-dehydrogenase (HAD) activities at the same level as endurance trained young subjects [9,48]. Adaptability in other parameters such as maximal oxygen consumption and muscle strength has also been reported in elderly [19,20] and old people [7] and supports a general maintained ability of aged individuals to adapt to exercise training. However, it is yet not clarified whether lifelong exercise training will enhance the oxidative capacity in skeletal muscle and whether skeletal muscle of elderly people maintains the ability to adapt in metabolic and angiogenic factors to exercise training.…”

Section: Accepted Manuscriptmentioning

confidence: 65%

Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly

Iversen

Krustrup

Rasmussen

et al. 2011

Experimental Gerontology

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International audienceThe aim of this study was to test the hypotheses that 1) skeletal muscles of elderly subjects can adapt to a single endurance exercise bout and 2) endurance trained elderly subjects have higher expression/activity of oxidative and angiogenic proteins in skeletal muscle than untrained elderly people. To investigate this, lifelong endurance trained elderly (ET; n=8) aged 71.3±3.4years and untrained elderly subjects (UT; n=7) aged 71.3±4years, performed a cycling exercise bout at 75% VO2max with vastus lateralis muscle biopsies obtained before (Pre), immediately after exercise and at 2h of recovery. Capillarization was detected histochemically and oxidative enzyme activities were determined on isolated mitochondria. GLUT4, HKII, Cyt c and VEGF protein expression was measured on muscle lysates from Pre-biopsies, phosphorylation of AMPK and P38 on lysates from Pre and 0' biopsies, while PGC-1α, VEGF, HKII and TFAM mRNA content was determined at all time points. ET had ~30% higher PDH, CS, SDH, α-KG-DH and ATP synthase activities and ~20% higher capillarization than UT, reflecting increased skeletal muscle oxidative capacity with lifelong endurance exercise training. In addition, acute exercise increased PGC-1α mRNA 11-fold and VEGF mRNA 4-fold at 2h of recovery in UT, and AMPK phosphorylation ~5-fold immediately after exercise, relative to Pre, indicating an ability to adapt metabolically and angiogenically to endurance exercise. However, in ET PGC-1α mRNA only increased 5 fold and AMPK phosphorylation ~2-fold, while VEGF mRNA remained unchanged after the acute exercise bout. P38 increased similarly in ET and UT after exercise. In conclusion, the present findings suggest that lifelong endurance exercise training ensures an improved oxidative capacity of skeletal muscle, and that skeletal muscle of elderly subjects maintains the ability to respond to acute exercise

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Section: Accepted Manuscriptmentioning

confidence: 65%

Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly

Iversen

Krustrup

Rasmussen

et al. 2011

Experimental Gerontology

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“…Previous research has shown that performing exercise at the same absolute and relative intensity after 16 weeks of exercise training designed to improve muscle hypertrophy results in a blunted CK response. 56 In addition, when trained weightlifters were compared with untrained individuals, the serum CK response to a strenuous resistance training session was lower in the weightlifters. 57 These data demonstrate that hypertrophied muscles can perform exercise without the same CK response as untrained muscles.…”

Section: Discussionmentioning

confidence: 95%

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

Pistilli

Bogdanovich

Goncalves

et al. 2011

The American Journal of Pathology

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The activin receptor type IIB (ActRIIB) is a transmembrane receptor for transforming growth factor-␤ superfamily members, including myostatin, that are involved in the negative regulation of skeletal muscle mass. We tested the translational hypothesis that blocking ligand binding to ActRIIB for 12 weeks would stimulate skeletal muscle growth and improve muscle function in the mdx mouse. ActRIIB was targeted using a novel inhibitor comprised of the extracellular portion of the ActRIIB fused to the Fc portion of murine IgG (sActRIIB), at concentrations of 1.0 and 10.0 mg/kg ؊1 body weight. After 12 weeks of treatment, the 10.0 mg/kg ؊1 dose caused a 27% increase in body weight with a concomitant 33% increase in lean muscle mass. Absolute force production of the extensor digitorum longus muscle ex vivo was higher in mice after treatment with either dose of sActRIIB, and the specific force was significantly higher after the lower dose (1.0 mg/kg ؊1 ), indicating functional improvement in the muscle. Circulating creatine kinase levels were significantly lower in mice treated with sActRIIB, compared with control mice. These data show that targeting the ActRIIB improves skeletal muscle mass and functional strength in the mdx mouse model of DMD, providing a therapeutic rationale for use of this molecule in treating skeletal myopathies.

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“…These differences are probably affected by the duration and the intensity of training (Buchheit, Voss, Nybo, Mohr, & Racinais, 2011;Hurley et al, 1995). However SGOT increased during the competitive period finding which the literature review supports.…”

Section: Enzymesmentioning

confidence: 60%

Biochemical Changes from Preparation to Competitive Period in Soccer

Gioldasis

2016

IntJSCS

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The aim of the current study was to indicate the biochemical changes during the preparation and competitive soccer period. The literature review showed that biochemical parameters such as transaminases, enzymes and other factors change significantly from the preparation to the competitive period. The sample of the study included twenty five professional soccer players whose biochemical parameters assessed in the beginning of the preparation period, in the middle, in the end of the preparation period, as well as in the middle of the competitive period. The parameters that were assessed were SGPT, SGOT, γ-GT, CPK, LDH, calcium, potassium, magnesium, sodium, creatinine, triglycerides, urea, uric acid, creatinine and B-12. The results showed that SGPT, SGOT and CPK reduced during the preparation period whereas they increased in the competitive period. Furthermore, LDH, urea, uric acid and creatinine reduced from the beginning of the preparation period to the competitive period. Calcium also reduced during the competitive period whereas magnesium, sodium and B-12 increased. These changes are probably explained by the training aim to improve the aerobic and anaerobic capacity of the players throughout the training sessions of the preparation period.

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Effects of Strength Training on Muscle Hypertrophy and Muscle Cell Disruption in Older Men

Cited by 100 publications

References 6 publications

Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly

Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

Biochemical Changes from Preparation to Competitive Period in Soccer

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