Abstract:In vitro, streptomycin and amiloride block the mechano-electrical transduction channels in isolated auditory hair cells of mammals and birds. The present in vivo experiments investigate their action in the intact pigeon inner ear. Streptomycin dissolved in artificial endolymph at concentrations between 1.0 and 6.2 mmol/1 was applied into the scala media. After a bolus injection (0.09 to 0.36 gl) the endocochlear potential (EP) was elevated from 6.8 to 7.9 mV. Similarly applied boll of 0.09 to 0.55 p.1 of amilo… Show more
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