Effects of streptozotocin-induced diabetes on low density lipoprotein receptor expression in rat adipose tissue

Swami, Srilatha; Sztalryd, Carole; Kraemer, Fredric B.

doi:10.1016/s0022-2275(20)37611-2

Cited by 12 publications

(1 citation statement)

References 28 publications

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“…Thus, insulin resistance promotes the accumulation of LDL in blood vessels due to IR inactivity. It is also reported that insulin stimulates LDLR expression, [ 100,101 ] which is also an IR‐dependent signaling event. In type‐2 diabetes, insulin cannot interact with IR to activate any downstream signaling, leading to repression of LDLR expression.…”

Section: Association Between Ir and Ldlrmentioning

confidence: 99%

A comprehensive account of insulin and LDL receptor activity over the years: A highlight on their signaling and functional role

Chandra

2021

J Biochem & Molecular Tox

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Insulin receptor (IR) was discovered in 1970. Shortcomings in IR transcribed signals were found pro-diabetic, which could also inter-relate obesity and atherosclerosis in a time-dependent manner. Low-density lipoprotein receptor (LDLR) was discovered in 1974. Later studies showed that insulin could modulate LDLR expression and activity. Repression of LDLR transcription in the absence or inactivity of insulin showed a direct cause of atherosclerosis. Leptin receptor (OB-R) was found in 1995 and its resistance became responsible for developing obesity.The three interlinked pathologies namely, diabetes, atherosclerosis, and obesity were later on marked as metabolic syndrome-X (MSX). In 2012, the IR-LDLR interassociation was identified. In 2019, the proficiency of signal transmission from this IR-LDLR receptor complex was reported. LDLR was found to mimic IR-generated signaling path when it remains bound to IR in IR-DLR interlocked state. This was the first time LDLR was found sending messages besides its LDL-clearing activity from blood vessels.

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Section: Association Between Ir and Ldlrmentioning

confidence: 99%