Effects of stress on parental care are sexually dimorphic in prairie voles

Bales, Karen L.; Kramer, Kristin M.; Lewis-Reese, Antoniah D.; Carter, C. Sue

doi:10.1016/j.physbeh.2005.11.002

Cited by 75 publications

(54 citation statements)

References 45 publications

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“…Though our findings did not find significant direct effects of UCN II on stress hormones, UCN II did increase passive parental behavior which in turn itself reduces stress, at least in males of this species [19]. Ultimately, our findings implicate peripherally administered UCN II and CRH2 in passive parental behavior in the prairie vole.…”

Section: Nih Public Accesscontrasting

confidence: 67%

“…Arima and Aguilera [39] have observed CRH2 transcripts in the supraoptic nucleus and the paraventricular nucleus (where OT and AVP are produced), and more importantly have colocalized CRH2 mRNA with AVP and OT mRNA in the supraoptic nucleus. These findings suggest that CRH2 and its respective ligands may be playing a role in the hypothalamo-neurohypophyseal system, and thus on parenting behavior.Though our findings did not find significant direct effects of UCN II on stress hormones, UCN II did increase passive parental behavior which in turn itself reduces stress, at least in males of this species [19]. Ultimately, our findings implicate peripherally administered UCN II and CRH2 in passive parental behavior in the prairie vole.…”

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confidence: 67%

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Urocortin II increases spontaneous parental behavior in prairie voles (Microtus ochrogaster)

Samuel

Hostetler

Bales

2008

Behavioural Brain Research

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Stress and anxiety play a role in many psychological processes including social behavior. The present study examines the effects of urocortin II (UCN II) on spontaneous parental behavior in adult prairie voles (Microtus ochrogaster). UCN II was found to increase passive parental behavior in voles while not affecting any stress-related measures. Delineating the mechanism of this change will aid in our understanding of the regulation of parenting. Keywordscorticotrophin-releasing hormone; urocortin I, II, and III; parenting; monogamy; vole Urocortin (UCN) II, also known as stresscopin-related peptide, is a 38 amino acid member of the mammalian corticotropin-releasing hormone (CRH) peptide family, which also includes CRH, UCN I, and UCN III [1;2]. CRH mainly binds to type 1 CRH receptors (CRH1), while UCN II and III bind primarily to type 2 CRH receptors, and UCN I binds to both (CRH2) [1]. Each of these hormones has distinctive distribution patterns in the central nervous system and the periphery, suggesting each peptide may have distinct behavioral and physiological effects, although all have been associated with anxiety [2][3][4][5]. In general, agonism of CRH1 receptors is posited to be anxiogenic and agonism of CRH2 receptors is posited to be anxiolytic [6]. UCN II, however, has produced mixed results in tests of anxiety. Central administration of UCN II increased anxiety-like behavior when given intracerebroventricularly (ICV) thirty minutes before a plus maze test [7;8]. It also caused increased anxiety when administered by osmotic minipump infusion during a novel object exploration task [9]. However, UCN II minipump administration caused no differences in open field behavior [9]. In another study, ICV UCN II caused no change in plus-maze behavior either ten minutes or one hour postinjection [10]; however, animals tested four hours post-administration showed a decrease in anxiety-like behavior. It is thus possible that the effects of UCN II on anxiety are dependent on the time-course of administration [6], with anxiogenic effects peaking earlier than anxiolytic effects. Administration of the glucocorticoid, dexamethasone, leads to an increase in UCN II mRNA, which has been suggested to mediate anxiolytic functions of UCN II [11]. Effects of CRH2 ligands on other aspects of behavior, particularly social behavior, are thus far little studied, as are the effects of peripheral administration on anxiety and social behaviors.Corresponding author. Address: Department of Psychology, One Shields Ave., University of California, Davis, CA 95616. Phone: 530-754-5890, Fax: 530-752-2087, Email: klbales@ucdavis.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered w...

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Section: Nih Public Accesscontrasting

confidence: 67%

contrasting

confidence: 67%

Urocortin II increases spontaneous parental behavior in prairie voles (Microtus ochrogaster)

Samuel

Hostetler

Bales

2008

Behavioural Brain Research

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“…oxytocin) (Bales et al, 2004) and stress [e.g. corticotropin releasing factor (CRF), cortisol] (Bales et al, 2006;Lee et al, 2006), which have been extensively reviewed elsewhere Meaney, 2001;Rilling and Young, 2014). However, evidence is accumulating that feeding behavior and parental care are also tightly linked at a mechanistic level (O'Rourke and Renn, 2015).…”

Section: Coordination Of Feeding and Parenting Circuitsmentioning

confidence: 99%

Modification of feeding circuits in the evolution of social behavior

Fischer

O’Connell

2017

Journal of Experimental Biology

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Adaptive trade-offs between foraging and social behavior intuitively explain many aspects of individual decision-making. Given the intimate connection between social behavior and feeding/foraging at the behavioral level, we propose that social behaviors are linked to foraging on a mechanistic level, and that modifications of feeding circuits are crucial in the evolution of complex social behaviors. In this Review, we first highlight the overlap between mechanisms underlying foraging and parental care and then expand this argument to consider the manipulation of feeding-related pathways in the evolution of other complex social behaviors. We include examples from diverse taxa to highlight that the independent evolution of complex social behaviors is a variation on the theme of feeding circuit modification.

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“…The EPM consisted of two open and two closed arms, each 67 cm long and 5.5 cm in width On day 62 (1 week later), voles were tested for alloparental behavior in response to a pup. Procedures for testing parental behavior were modeled on previous work done in this lab (Roberts et al, 1998;Bales et al, 2004b;Bales et al, 2004c;Bales et al, 2006). Females were first given 45 min to adjust to an empty testing arena.…”

Section: Behavioral Testingmentioning

confidence: 99%

Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles

Bales¹,

Westerhuyzen²,

Lewis-Reese³

et al. 2007

Hormones and Behavior

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157

108

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The present study examines the developmental consequences of neonatal exposure to oxytocin on adult social behaviors in female prairie voles (Microtus ochrogaster). Female neonates were injected within 24 hours of birth with isotonic saline or one of four dosages of oxytocin (OT). As adults, females were tested in an elevated plus-maze paradigm (a measure of anxiety and exploratory behavior), and for alloparental behavior and partner preferences. At 2 mg/kg OT, females took longer to approach pups, but were the only group to form a statistically significant within-group partner preference. At 4 mg/kg OT, females retrieved pups significantly more frequently but no longer displayed a partner preference; while females treated developmentally with 8 mg/kg spent significantly more time in side-to-side contact with a male stranger than any other treatment group. OT may have broad developmental consequences, but these effects are not linear and may both increase and decrease the propensity to display behaviors such as pair-bonding.The neuropeptide oxytocin (OT) has been implicated in social behavior in both male and female mammals. OT's peripheral effects include the induction of parturition and milk let-down, while central OT has been associated with the onset of maternal behavior (Pedersen and Prange Jr., 1979;Pedersen et al., 1982;Pedersen and Boccia, 2002), and other positive social behaviors such as pair-bonding (Insel and Hulihan, 1995;Carter and Altemus, 1997;Cho et al., 1999) and male parental care (Bales et al., 2004b). It is also becoming evident that manipulations of OT and a related peptide, arginine vasopressin (AVP) during the perinatal period of life can have life-long implications for social behavior and neuroendocrine function (Stribley and Carter, 1999;Diaz-Cabiale et al., 2000;Carter, 2003;Lipschitz et al., 2003). These exposures can be either endogenous, through responses to touch, warmth (Uvnas-Moberg, 1998) or perhaps through OT in breast milk (Leake et al., 1981); they could also be pharmacological, for example through use of pitocin or an oxytocin antagonist to manipulate labor (Husslein, 2002).In this context, we have begun to examine the consequences of OT manipulations in early life for subsequent social behaviors and neuroendocrine variables. Because we were particularly interested in the developmental control of social behaviors such as pair-bond formation and biparental behaviors, we chose to study the socially monogamous prairie vole (Microtus ochrogaster). In this species both males and females display parental care and form selective partner preferences indicative of pair-bonding, although the mechanisms for these behaviors Please direct correspondence to: Karen L. Bales, Dept. of Psychology, One Shields Ave., University of California, Davis, CA 95616. Ph: (530) 754−5890, Fax: (530) 752−2087, email: klbales@ucdavis.edu Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this e...

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Effects of stress on parental care are sexually dimorphic in prairie voles

Cited by 75 publications

References 45 publications

Urocortin II increases spontaneous parental behavior in prairie voles (Microtus ochrogaster)

Urocortin II increases spontaneous parental behavior in prairie voles (Microtus ochrogaster)

Modification of feeding circuits in the evolution of social behavior

Oxytocin has dose-dependent developmental effects on pair-bonding and alloparental care in female prairie voles

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