A chronically ill child is financially, emotionally, and physically demanding on the family system. Although researchers have identified a plethora of risks, stressors, and needs of the families with a chronically ill child, there is a scarceness of evidence-based interventions in the existing literature. The purpose of the authors in this study was to critically analyze current treatment and identify the gaps in the available research. Findings revealed that there is a lack of support for empirically tested interventions that can help parents, siblings, and families of chronically ill children. The issues raised within this literature review bring attention to the need for shifts in research from exploratory to evidence based in order to successfully achieve more effective care.