Effects of strontium-incorporated micro/nano rough titanium surfaces on osseointegration via modulating polarization of macrophages

Xu, Antian; Xie, Yiwen; Xu, Jiangang; Li, Jia; Wang, Hui

doi:10.1016/j.colsurfb.2021.111992

Cited by 35 publications

(19 citation statements)

References 45 publications

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“…The tibia implantation model is a classical experimental model used in many studies to evaluate bone tissue (osseointegration), bone marrow tissue (myelointegration), fibrous tissue, and/or inflammatory reactions at the implant–tissue interface. This model is used not only in the field of dentistry but also in orthopaedic and rehabilitation sciences (Bai et al, 2018; Guglielmotti et al, 2019; Schliephake et al, 2015; Trindade et al, 2018; Xu et al, 2021a; Xu et al, 2021b). A rodent tibia has similarities with human bone biology and is a good location for assessing the effect of systemic drugs on bone (Al‐Subaie et al, 2016; Baron et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing

Chen

Shi

et al. 2022

J Clinic Periodontology

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Aim: Emerging studies have shown that immune response to biomaterial implants plays a central role in bone healing. Ipriflavone is clinically used for osteoporosis.However, the mechanism of ipriflavone in immune response to implants in early stages of osseointegration remains unclear. In this study, we aimed to investigate the potential role of ipriflavone in early bone healing process and uncover the underlying mechanism. Materials and Methods:We carried out histological examination as well as analysis of proinflammatory cytokines and NLRP3 inflammasome activation in a tibial implantation mouse model with intra-peritoneal injection of ipriflavone. In addition, we explored the mechanism of ipriflavone in the regulation of NLRP3 inflammasome activation in macrophages.Results: In vivo, ipriflavone ameliorated host inflammatory response related to NLRP3 inflammasome activation at implantation sites, characterized by reductions of inflammatory cell infiltration and proinflammatory cytokine interleukin-1β levels.Ipriflavone treatment also showed beneficial effects on early osseointegration. Further investigations of the molecular mechanism showed that the suppression of NLRP3 inflammasome acts upstream of NLRP3 oligomerization through abrogating the production of reactive oxygen species.Conclusions: These results revealed an anti-inflammatory role of ipriflavone in NLRP3 inflammasome activation through improving mitochondrial function. This study provides a new strategy for the development of immune-regulated biomaterials and treatment options for NLRP3-related diseases.

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Section: Discussionmentioning

confidence: 99%

Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing

Chen

Shi

et al. 2022

J Clinic Periodontology

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“…At the same time, Sr 2+ can inhibit macrophage differentiation to osteoclasts by down-regulating TRAP, MMP-9 and CKT expression ( Wu T. et al, 2021 ). Xu et al (2021) fabricated Sr 2+ incorporated micro\nano rough titanium surface (Sr-SLA) and immunoreaction of macrophages was further investigated. The Vivo experience showed that compared to SLA implants, less classically activated M1 macrophages infiltration and more alternatively activated M2 macrophages infiltration were observed at the implantation site of Sr-SLA implants, accompanied with a more bone formation.…”

Section: Immunological Mechanism Of Strontium For Osteogenesismentioning

confidence: 99%

Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation

You

Zhang

Zhou

2022

Front. Bioeng. Biotechnol.

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With the development of bone tissue engineering bio-scaffold materials by adding metallic ions to improve bone healing have been extensively explored in the past decades. Strontium a non-radioactive element, as an essential osteophilic trace element for the human body, has received widespread attention in the medical field due to its superior biological properties of inhibiting bone resorption and promoting osteogenesis. As the concept of osteoimmunology developed, the design of orthopedic biomaterials has gradually shifted from “immune-friendly” to “immunomodulatory” with the aim of promoting bone healing by modulating the immune microenvironment through implanted biomaterials. The process of bone healing can be regarded as an immune-induced procedure in which immune cells can target the effector cells such as macrophages, neutrophils, osteocytes, and osteoprogenitor cells through paracrine mechanisms, affecting pathological alveolar bone resorption and physiological bone regeneration. As a kind of crucial immune cell, macrophages play a critical role in the early period of wound repair and host defense after biomaterial implantation. Despite Sr-doped biomaterials being increasingly investigated, how extracellular Sr2+ guides the organism toward favorable osteogenesis by modulating macrophages in the bone tissue microenvironment has rarely been studied. This review focuses on recent knowledge that the trace element Sr regulates bone regeneration mechanisms through the regulation of macrophage polarization, which is significant for the future development of Sr-doped bone repair materials. We will also summarize the primary mechanism of Sr2+ in bone, including calcium-sensing receptor (CaSR) and osteogenesis-related signaling pathways.

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“…With the success of bionics in various fields. In addition to conventional methods such as sandblasting and acid etching to roughen the implant surface ( Mahajan and Sidhu, 2018 ; He et al, 2019 ; Xu A.-t. et al, 2021 ), an increasing number of researchers have simulated and constructed structures similar to natural bone on the implant surface from the perspective of bionics ( Saita et al, 2016 ).…”

Section: Surface Nanocrystallizationmentioning

confidence: 99%

Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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After bone defects reach a certain size, the body can no longer repair them. Tantalum, including its porous form, has attracted increasing attention due to good bioactivity, biocompatibility, and biomechanical properties. After a metal material is implanted into the body as a medical intervention, a series of interactions occurs between the material’s surface and the microenvironment. The interaction between cells and the surface of the implant mainly depends on the surface morphology and chemical composition of the implant’s surface. In this context, appropriate modification of the surface of tantalum can guide the biological behavior of cells, promote the potential of materials, and facilitate bone integration. Substantial progress has been made in tantalum surface modification technologies, especially nano-modification technology. This paper systematically reviews the progress in research on tantalum surface modification for the first time, including physicochemical properties, biological performance, and surface modification technologies of tantalum and porous tantalum.

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Effects of strontium-incorporated micro/nano rough titanium surfaces on osseointegration via modulating polarization of macrophages

Cited by 35 publications

References 45 publications

Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing

Ipriflavone suppresses NLRP3 inflammasome activation in host response to biomaterials and promotes early bone healing

Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation

Advances in surface modification of tantalum and porous tantalum for rapid osseointegration: A thematic review

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