Effects of Strontium on Calcium Metabolism in Rats II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats

Morohashi, Tomio; Sano, Tsuneyoshi; Yamada, Shoji

doi:10.1254/jjp.64.155

Cited by 63 publications

(20 citation statements)

References 31 publications

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“…An essential function for Li at very low levels of intake has been postulated independently by two groups of investigators using goats [12] or rats [13]. Also promising are the results of Japanese and other investigators [4][5][6][7][8] pertaining the physological role of small quantities of Sr in the context of its positive influence on Ca metabolism in man and animals. Still remains for elucidation the question to what extent Sr and Li may be accepted as essential microelements for animal and man organism.…”

Section: Resultsmentioning

confidence: 99%

“…In the diet, Sr is strongly discriminated by the organism in favor of Ca [3]. From a more recent paper of Morohashi et al [4] it is evident that stable Sr, in rat experiments (Wistar) at doses below 175 lmol/day, does not have a toxic effect on Ca metabolism and on its content in the bone. At the dose of 87.5 lmol/day these authors observed even some beneficial effects of increased Ca content in the bone.…”

Section: Introductionmentioning

confidence: 99%

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Content of strontium, lithium and calcium in selected milk products and in some marine smoked fish

Nabrzyski¹,

Gajewska

2002

Nahrung

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The strontium, lithium and calcium contents have been determined in 87 samples of five kinds of milk-fermented products, as well as in 93 samples of ten kinds of marine smoked fish. The samples were purchased on the local market. The representative samples were dry ashed in quartz crucibles and the ash was treated with suitable amounts of conc. HCl and a few drops of conc. HNO3. The obtained sample solution was then used for the determination of Sr, Li and Ca by the flame atomic absorption spectrometry (AAS) method. Ca and Li were determined using the air-acetylene flame and Sr with nitrous oxide-acetylene flame, according to the manufacturer's recommendations. The contents of Sr in the fermented milk products ranged from 0.21 to 0.79 (mean 0.44 +/- 0.07) and in the marine smoked fish from 0.02 to 4.63 (mean 1.16 +/- 0.24) mg/kg of the edible form of both products. Li contents in the milk products ranged from 0.01 to 0.50 (mean 0.07 +/- 0.04) and in the smoked fish from 0.00 to 0.58 (mean 0.11 +/- 0.08) mg/kg. The calcium was highest in the milk products and ranged from 1,010 to 2,020.0 (mean 1,377 +/- 143) mg/kg. In the smoked fish calcium varied strongly and ranged from 40 to 1,052 (mean 303 +/- 53) mg/kg of the edible form. The calculated average ratio of strontium to calcium (mg Sr/1 g Ca) in the milk beverages and yogurts amounted 0.32 and in the smoked fish was 12 times as high and amounted 3.84. The main purpose of this work was to present Ca, Sr and Li together. This is justified because Sr and to some extent also Li are able to modulate Ca metabolism and vice versa.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Content of strontium, lithium and calcium in selected milk products and in some marine smoked fish

Nabrzyski¹,

Gajewska

2002

Nahrung

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“…The currently available data indicate that strontium has metabolic effects on bone in vivo. There is experimental evidence that strontium administration at low dose reduces bone resorption and increases bone formation, resulting in increased bone mass in normal animals [1][2][3][4]. Strontium ranelate (C 12 H 6 N 2 O 8 SSr 2 ), semi-synthetic form of strontium, is the first antiosteoporotic treatment that has dual mode of action and simultaneously increases bone formation, while decreasing bone resorption.…”

Section: Introductionmentioning

confidence: 99%

The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

Wei

Wang²,

Guo³

et al. 2010

Biol Trace Elem Res

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The effects of Cordyceps sinensis (Caterpillar fungus) and strontium ranelate on ovariectomized osteopenic rats was studied in this paper. After the rats were treated orally with C. sinensis, strontium, and C. sinensis rich in strontium ranelate (CSS) respectively, serum alkaline phosphatase (ALP), tartarate-resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine, C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol, and interferon-gamma (IFN-γ) level were examined. The beneficial effects of CSS on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level, and IFN-γ level. At the same time, CSS also increase the OC and estradiol level in ovariectomized osteopenic rats. This study demonstrates the value of C. sinensis rich in strontium ranelate in the management of postmenopausal osteoporosis in humans.

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“…400 mg/kg/day, disturbs calcium metabolism in intact rats and produces inhibitory effects on calcium metabolism, such as decreased intestinal calcium absorption, decreased bone formation and resorption, negative calcium balance, and decreased calcium contents in bone (6,7). On the other hand, a strontium-containing substance (S12911) has been shown to prevent femoral osteopenia in OVX rats (8).…”

mentioning

confidence: 99%

Effects of Strontium on Calcium Metabolism in Rats. II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats.

Morohashi¹,

Sano²,

Harai³

et al. 1995

Jpn.J.Pharmacol

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ABSTRACT-The effects of stable strontium were investigated in ovariectomized (OVX) rats by calcium balance and calcium kinetic studies, histomorphometric analysis and measurements of calcium levels in bone. After 10 days of pair-feeding with a control diet, 71-day-old female Wistar rats were either shamoperated (Sham group) or ovariectomized. The OVX rats were divided into two subgroups: those that were treated with strontium (OVX+Sr group, strontium intake; 87.5 ymol/day/rat) and those that were not (OVX group). Both groups were pair-fed their respective control or strontium diets for 2 weeks. Calcein and tetracycline were injected every 2 weeks from 1 week before ovariectomy to calculate the rate of bone formation in the diaphyseal femora cortex (°1o BFFC). In the OVX group, urinary calcium and % BFFC decreased, while bone resorption, bone formation and femora length increased at the end of the experiment, as compared with those in the Sham group. No such changes were observed in rats in the OVX+Sr group. The calcium balance, calcium levels in bone and trabecular bone volume in the metaphysis did not change in any of the three groups. These results suggest that strontium may be able to prevent the changes in bone turnover induced by estrogen deficiency. Keywords:Calcium, Strontium, Bone formation, Bone resorption, OvariectomyOvariectomized (OVX) animal models in a variety of species have been used to evaluate the mechanism of or to assess the effect of drugs in estrogen deficiency (1 -4). Although several histomorphometric studies have been performed to investigate the mechanism of estrogen deficiency, only a few have also studied calcium metabolism. Indeed, changes in calcium metabolism are closely associated with, or induce, morphometric disorders in OVX animals. Thus, the analysis of calcium metabolism in OVX rats is necessary to evaluate the mechanism of estrogen deficiency, and calcium balance and calcium kinetic studies are useful for investigating it (5). Our previous report showed that a large amount of strontium, more than approx. 400 mg/kg/day, disturbs calcium metabolism in intact rats and produces inhibitory effects on calcium metabolism, such as decreased intestinal calcium absorption, decreased bone formation and resorption, negative calcium balance, and decreased calcium contents in bone (6, 7). On the other hand, a strontium-containing substance (S12911) has been shown to prevent femoral osteopenia in OVX rats (8). Morphometrically, the effects of this substance can be observed within 60 days after ovariectomy, at dosages that correspond to less than approx. 100 mg/kg/day of strontium (8). It has been considered that low-dose strontium has a beneficial effect in OVX animals. However, there are few reports on calcium metabolism that investigate the effects of lowdose strontium in OVX rats. Wronski et al. (9) demonstrated that changes in histomorphometric parameters can be detected as early as 14 days after ovariectomy by measuring the percent of cancellous bone volume in tibiae. We hypothesized...

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Effects of Strontium on Calcium Metabolism in Rats II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats

Cited by 63 publications

References 31 publications

Content of strontium, lithium and calcium in selected milk products and in some marine smoked fish

Content of strontium, lithium and calcium in selected milk products and in some marine smoked fish

The Mechanism of Cordyceps sinensis and Strontium in Prevention of Osteoporosis in Rats

Effects of Strontium on Calcium Metabolism in Rats. II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats.

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