Effects of strontium substitution on the phase transformation and crystal structure of calcium phosphate derived by chemical precipitation

He, Li; Dong, Gang; Deng, Chunlin

doi:10.1016/j.ceramint.2016.04.116

Cited by 54 publications

(24 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The current researches lack comparisons between the effects of Sr and Mg substitution on BCP and overall knowledge of Sr and Mg substitutions in large amounts. Moreover, substitution of both Mg and Sr during the liquid synthetic process is an effective way of adjusting the compositions of biphasic calcium phosphate products . The methods to synthesize substituted BCP vary, and the results of ion substitution into BCP can be totally contrary due to different reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

“…28,29 However, most studies about substituted BCP have focused on the substitution of a sole ion, and the substitution amount is usually ranged from 0% to 20%. 1,[30][31][32][33] The current researches lack comparisons between the effects of Sr and Mg substitution on BCP and overall knowledge of Sr and Mg substitutions in large amounts. Moreover, substitution of both Mg and Sr during the liquid synthetic process is an effective way of adjusting the compositions of biphasic calcium phosphate products.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, substitution of both Mg and Sr during the liquid synthetic process is an effective way of adjusting the compositions of biphasic calcium phosphate products. 1,32 The methods to synthesize substituted BCP vary, and the results of ion substitution into BCP can be totally contrary due to different reaction conditions. For example, He et al 32 have reported that the b-TCP fraction in BCP could increase or decrease with increasing Sr addition because of the different synthetic approaches.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of both Sr and Mg substitution on compositions of biphasic calcium phosphate derived from hydrothermal method

Zhang

Gao

et al. 2017

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

Biphasic calcium phosphate (BCP) ceramics have received much attention in the field of biomaterials. Regulation of phase compositions of BCP is extremely important for improving their bioactivity. In this study, the effects of Sr-and Mgaddition on the phase composition and morphology of BCP ceramics, prepared by a conventional hydrothermal way, were investigated deeply. The results indicated that the addition of Sr and Mg both facilitated the generation of b-tricalcium phosphate (b-TCP), and the relationships between the addition and the relative content of b-TCP under different pH 8.5 and 10.5 were similar. The relative content of b-TCP phase increased linearly with the Sr addition. Meantime, the relative content of b-TCP changed quadratically with the Mg addition and reached its peak when the Mg addition was up to 30%. Besides, the fraction of b-TCP phase of samples synthesized at pH 8.5 was higher than that of samples synthesized at pH 10.5 when the substitution was same. The morphology did not change significantly in Sr-substituted samples while an enhancement in density was observed with Mg addition in Mg-substituted samples. These results and findings provide more comprehensive knowledge about controlling the phase compositions of BCP by changing the initial substitution of Mg and Sr.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of both Sr and Mg substitution on compositions of biphasic calcium phosphate derived from hydrothermal method

Zhang

Gao

et al. 2017

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

show abstract

“…However, high temperature sintering in the process of chemical synthesis usually leads to a more perfect grain and poor degradation of BCP, thus reducing the biological activity (Fellah, Gauthier, Weiss, Chappard, & Layrolle, 2008;Yuan et al, 2010). Previous studies have found that ions doping can cause lattice distortion and decrease crystallinity (He, Dong, & Deng, 2016), improving the degradation rate and biological response (Schumacher & Gelinsky, 2015). Thus, it is important to improve the bioactivity and degradation of BCP ceramics.…”

mentioning

confidence: 99%

“…Several in vitro studies suggested that Sr-substituted HA scaffolds promoted the osteogenic differentiation of human osteoblast-like cells Lin et al, 2013). Recently, several studies have focused on the effect of low-content Sr incorporation into HA on the β-TCP phase transformation, resulting in BCP ceramics (He et al, 2016;Nandha Kumar, Mishra, Udhay Kiran, & Kannan, 2015). The degradation and osteogenic properties of such materials need to be optimized.…”

mentioning

confidence: 99%

Strontium‐substituted biphasic calcium phosphate microspheres promoted degradation performance and enhanced bone regeneration

Chen

Liu

Jiang

et al. 2019

J Biomedical Materials Res

View full text Add to dashboard Cite

Biphasic calcium phosphate (BCP) ceramics are the subject of much attention for use as bone replacement material. However, it remains a challenge to promote the degradation and osteoinductivity performances of BCP ceramics. In this work, novel BCP ceramic microspheres with good degradation and excellent osteoinductivity were prepared through high-content strontium (Sr) doping. The in vitro results indicated that the Sr10-BCP, Sr40-BCP, and Sr80-BCP microspheres all had their HA crystals partially transformed to the beta tricalcium phosphate phase following high-temperature sintering because of Ca-deficient HA formed by the partial substitution of Ca ions by Sr ions. In addition, the degradation rate was increased with the doping of increasing amounts of Sr. All prepared microspheres enhanced human bone marrow-derived mesenchymal stem cells attachment and proliferation. Specifically, among these modified microspheres, the Sr40-BCP microspheres showed the highest osteogenic potential. Furthermore, Sr40-BCP and HA microspheres were implanted in a calvarial defect model of rat to evaluate the in vivo bone augmentation ability. The results indicated that Sr40-BCP microspheres degraded more completely and significantly promoted new bone regeneration compared with HA microspheres. In conclusion, Sr40-BCP microspheres have excellent potential for degradation and bone regeneration and are promising osteogenic materials. K E Y W O R D Sbiphasic calcium phosphate, bone regeneration, degradation, microspheres, strontiumsubstituted

show abstract

Incorporation of graphene oxide and calcium phosphate in the PCL/PHBV core‐shell nanofibers as bone tissue scaffold

Mollaqasem

Asefnejad

Nourani

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Bone tissue scaffolds should have both desired mechanical stability and cell activities including biocompatibility, cell differentiation, and maturation. Also, suitable mineralization is another key factor for these materials. Hence, in current work, in order to achieve a scaffold with desired mechanical and bioactivity properties, core-shell nanofibers based on the polycaprolactone and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) with different concentration of graphene oxide (GO) (0.5, 1, and 1.5 wt%) and calcium phosphate (CP) (1 and 3 wt%) were prepared to utilize as bone scaffold. Microstructure of nanofibers observed by field emission scanning electron microscope (FE-SEM) and results exhibited that the most of nanofibers had 270-500 nm diameter. Attenuated total reflectance Fourier transform infrared spectroscopy and energy dispersive X-ray evaluations verified appearance of GO and CP into the electrospun scaffolds (ES). Transmission electron microscopy analysis endorsed core-shell structure of nanofibers. X-ray diffraction study moreover determination of semicrystalline structure, verified presence of GO and CaPO 4 into the nanofibers. Water contact angle demonstrates that, ES2 and ES3 situated in suitable domain of hydrophilicity. Tensile analysis determined that, ES2, ES3, and ES4 had the highest mechanical properties for use as bone scaffold. Cell viability assessment confirmed biocompatibility of scaffold during 7 days. Alkaline phosphatase and alizarin red staining exhibited maturating and differentiating of osteocytes after 21 days seeding on the scaffolds.

show abstract

Effects of strontium substitution on the phase transformation and crystal structure of calcium phosphate derived by chemical precipitation

Cited by 54 publications

References 24 publications

Effects of both Sr and Mg substitution on compositions of biphasic calcium phosphate derived from hydrothermal method

Effects of both Sr and Mg substitution on compositions of biphasic calcium phosphate derived from hydrothermal method

Strontium‐substituted biphasic calcium phosphate microspheres promoted degradation performance and enhanced bone regeneration

Incorporation of graphene oxide and calcium phosphate in the PCL/PHBV core‐shell nanofibers as bone tissue scaffold

Contact Info

Product

Resources

About