Effects of structurally – related impurities on the crystal growth of curcumin spherulites

Heffernan, Claire; Ukrainczyk, Marko; Żegliński, Jacek; Hodnett, B.K.; Rasmuson, Åke C.

doi:10.1039/d2ce00223j

Cited by 2 publications

(4 citation statements)

References 26 publications

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“…58,59 In contrast, TMAs might lead the solubility to decrease. 53,60 For instance, Heffernan et al 60 reported that demethoxycurcumin and bisdemethoxycurcumin resulted in a decrease in the solubility of curcumin at 283 K to 333 K, and that the downward trend was more noticeable with an increase in additive concentration. This is due to a stronger TMA−solute interaction compared with solute−solute interaction in the solution.…”

Section: Tmas Affect Nucleation By Acting On Solubilitymentioning

confidence: 99%

“…84 This is considered to be a result of the preferential interaction between the additives and the solutes. 60 Kitamura et al 81 reported that the growth of Lglutamic acid was inhibited because the inclusion of additives destroyed the original lattice network. Similarly, Prasad et al 35 detected by HPLC that the additive phenacetin was incorporated into the paracetamol crystal lattice.…”

Section: Effect Of Tmas On Crystal Growthmentioning

confidence: 99%

“…However, some special cases should be noted. Some studies have shown that TMAs increased the solubility to varying degrees by promoting the self-association of solute molecules , or changing the pH of the solution system. , In contrast, TMAs might lead the solubility to decrease. , For instance, Heffernan et al reported that demethoxycurcumin and bisdemethoxycurcumin resulted in a decrease in the solubility of curcumin at 283 K to 333 K, and that the downward trend was more noticeable with an increase in additive concentration. This is due to a stronger TMA–solute interaction compared with solute–solute interaction in the solution.…”

Section: Effect Of Tmas On Crystal Nucleationmentioning

confidence: 99%

“…In some cases, TMAs not only create steric hindrance by adsorption but also cause lattice distortion by incorporation into the crystal stucture . This is considered to be a result of the preferential interaction between the additives and the solutes . Kitamura et al reported that the growth of l -glutamic acid was inhibited because the inclusion of additives destroyed the original lattice network.…”

Section: Effect Of Tmas On Crystal Growthmentioning

confidence: 99%

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Role of Tailor-Made Additives in Crystallization from Solution: A Review

Zhu

Gao

et al. 2023

Ind. Eng. Chem. Res.

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Additives which share a similar molecular structure with the crystallizing parent molecule are called tailor-made additives (TMAs). The inclusion of well-chosen TMAs often has a significant impact on crystallization behaviors. However, how TMAs affect the solution crystallization has seldom been systematically summarized in recent years. Herein this paper reviews the role of TMAs in solution crystallization. First, the effects and action mechanisms of TMAs on crystal nucleation and growth are discussed, respectively. Next, the applications of TMAs in the regulation of crystal properties including the polymorphism, crystal habit, crystal size, and chirality are introduced. Then the recent progress of molecular simulation in predicting the role of TMAs is discussed. Finally, we analyze the existing problems in this field and give an outlook on the future development. This paper is helpful and useful to readers interested in the use of TMAs to control crystallization and design crystals with desired properties.

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