1996
DOI: 10.1021/ja961178h
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Effects of Structure on the Reactivity of α-Hydroxydialkylnitrosamines in Aqueous Solutions1

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Cited by 17 publications
(40 citation statements)
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“…Minnesota) 54 plus an excess of hog liver esterase (to generate α-hydroxy DMN, which has a t 1/2 of 7 s) 55 to P450 2E1, NADPH-P450 reductase, cytochrome b 5 , and NADPH. No evidence for production of N -nitroso- N -methylformamide was obtained in these experiments either.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Minnesota) 54 plus an excess of hog liver esterase (to generate α-hydroxy DMN, which has a t 1/2 of 7 s) 55 to P450 2E1, NADPH-P450 reductase, cytochrome b 5 , and NADPH. No evidence for production of N -nitroso- N -methylformamide was obtained in these experiments either.…”
Section: Resultsmentioning
confidence: 99%
“…Reported rates of non-enzymatic reactions in steps 8 and 9 are from the indicated references. 55, 61, 63, 64 …”
Section: Figurementioning
confidence: 99%
“…The indicated rate constants are for non-enzymatic hydration and dehydration of the aldehydes [40,41] and for hydrolysis of the α-hydroxy nitrosamine [42]. …”
Section: Figuresmentioning
confidence: 99%
“…The rates of hydration and dehydration have been measured in some cases and are relatively slow (Fig. 7) [40-42]. …”
Section: Introductionmentioning
confidence: 99%
“…The calculated half-life of N -methyl- N -nitrosocarbamic acid is about 1.5 min 45 whereas AMMN-derived N -α-hydroxymethyl- N -methylnitrosamine had a half-life of ~ 9 seconds at pH 7.4. 48,49 The stability of corresponding intermediate from NNK-4-OAc has not been investigated.…”
Section: Discussionmentioning
confidence: 99%