Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Jones, Katherine; Kimble, Rachel; Baker, Katherine; Tew, Garry A.

doi:10.1371/journal.pone.0278480

Cited by 14 publications

(9 citation statements)

References 64 publications

(439 reference statements)

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“…Previous reviews were either not recent 46 or included trials published prior to the recent advances in medical therapies. 47 While narrative reviews 48 may come to similar conclusions as systematic reviews, they lack the same level of methodological rigor or transparency.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity for Quiescent and Mildly Active Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Oketola,

Akinrolie,

Webber

et al. 2023

Journal of the Canadian Association of Gastroenterology

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Background Physical activity (PA) may benefit people with inflammatory bowel diseases (IBD) by improving immunological response, musculoskeletal function, and psychological health. Aims We distilled available evidence on the efficacy and safety of PA to improve health-related quality of life (HRQoL) and relieve persistent symptoms of fatigue, joint pain, abdominal pain, stress, anxiety, and depression in individuals with quiescent/mild IBD. Methods We searched for trials in eight databases and trial registries. Trials using PA as an adjunct therapy in the management of adults (≥18 years) with quiescent or mild IBD, published in English between 2011 and 2023 were identified. Summary effect estimates were expressed as standardized mean difference (SMD) or mean difference (MD) with 95% confidence interval (CI) using random-effects model. Results From the 10,862 citations retrieved, we included seven randomized controlled trials (RCTs) and one non-RCT. There was no evidence of benefit of PA on HRQoL (SMD 0.34, 95%CI −0.08 to 0.77; I2 57%); high heterogeneity was noted among included trials. PA was found to be efficacious in reducing anxiety (SMD −0.35, 95%CI −0.65 to −0.05; I2 0%). There was insufficient evidence to make conclusions regarding changes in fatigue, joint pain, abdominal pain, stress, and depression. All trials deemed physical activity safe. Conclusions PA contributes to reducing anxiety in quiescent/mild IBD. There is marked heterogeneity in methodology among trials investigating PA in adults with quiescent/mild IBD. This review highlights the need for consistent definitions of PA types and intensities in this field of research.

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Section: Discussionmentioning

confidence: 99%

Physical Activity for Quiescent and Mildly Active Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Oketola,

Akinrolie,

Webber

et al. 2023

Journal of the Canadian Association of Gastroenterology

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“…Таким образом, с позиции доказательной медицины, проведённые до 2022 года исследования предоставляют лишь предварительные данные о положительном влиянии упражнений на здоровье костей, мышечную функцию, психологическое благополучие, утомляемость, кардиореспираторную выносливость, состав тела, иммунные параметры и воспалительные биомаркеры [54]. Однако гипотеза о влиянии ФА на патогенные звенья большинства ХНИЗ полностью подтверждена: ФУ способны модифицировать воспалительный статус субъекта за счет снижения уровней провоспалительных цитокинов, включая IL-1, IL-6 и TNF-α.…”

Section: заключениеunclassified

Physical exercises as an effective adjuvant therapy of IBD in remission (review)

Kostyukevich,

Bakulin

2024

Koloproktologiâ

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Inflammatory bowel diseases (IBD) include Crohn’s disease and ulcerative colitis. IBDs are chronic diseases with a trajectory of remission and relapse. Drug therapy for IBD is not effective enough. There is a need for adjuvant therapy for IBD. The purpose of this review was to present the role of exercise and its impact on IBD. In this regard, a search is underway for additional tools to increase the frequency of achieving and maintaining remission. There is recent evidence that exercise induces a cascade of anti-inflammatory cytokines, specifically triggered by an exponential increase in muscle interleukin 6, and with regular exercise during remission may reduce basal levels of circulating inflammatory markers and potentially reduce chronic inflammation in IBD. Doctor’s recommendations for physical activity during remission can be effective as an additional component of anti-relapse treatment.

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“…Physical activity is defined as any bodily movement that substantially increases energy expenditure [11]. Some studies have suggested higher levels of physical activity may be associated with more favorable psychological health outcomes in those with IBD [12,13]. A recent narrative review described how greater time spent in physical activity may also be associated with decreased IBD prevalence, decreased IBD symptoms [14], and possibly, maintenance of disease remission [15].…”

Section: Introductionmentioning

confidence: 99%

Device-Measured Walking and Standing are Associated with Improved Quality of Life, Mental Health, and Biochemical Markers in Patients with Ulcerative Colitis: A Pilot Study

2024

J Dig Dis Hepatol

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Background: Device-measured daily steps/step cadence and other prominent behaviours occurring throughout the 24-hour day (i.e., sitting, lying, standing) have not been examined in patients with ulcerative colitis (UC). The degree to which these behaviours are associated with mental health, quality of life and clinical outcomes in this population is unknown. Aims: To explore the associations between device-based walking, step cadence, and sedentary time and clinical outcomes among UC patients. Methods: Patients with UC wore an activPAL TM accelerometer for 7 days to measure daily steps, step cadence, lying, standing, and sitting time. Outcomes included total Mayo score (TMS), risk of depression (PHQ-8), risk of anxiety (GAD-7), and health-related quality of life [HRQoL (SF-12)] which included mental composite scores (MCS) and physical composite scores (PCS). Blood and stool samples were used to measure C-reactive protein (CRP) and fecal calprotectin (FCP). Results: Of 30 participants, thirteen (43.3%) had moderate to severe UC symptoms. The percentage of patients with moderate to severe depression and anxiety symptoms were 25.0% and 57.1%, respectively. Average daily steps were 7,869 3339. Step cadence ≥ 100 steps/min was positively associated with mental HRQoL and TMS, and inversely associated with FCP. Standing time was positively associated with TMS and inversely associated with depression, anxiety, and FCP. Faster walking was negatively correlated with CRP. Conclusion: This study identifies potential associations between device-measured brisk walking/running and periods of standing with HRQoL, mental health, and clinical outcomes. This study should be replicated in a larger sample to determine if these associations remain.

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Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis

Cited by 14 publications

References 64 publications

Physical Activity for Quiescent and Mildly Active Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Physical Activity for Quiescent and Mildly Active Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Physical exercises as an effective adjuvant therapy of IBD in remission (review)

Device-Measured Walking and Standing are Associated with Improved Quality of Life, Mental Health, and Biochemical Markers in Patients with Ulcerative Colitis: A Pilot Study

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