Effects of styrene and styrene oxide on glutathione-related antioxidant enzymes

Carlson, Gary P.; Turner, Meredith; Mantick, Nancy A.

doi:10.1016/j.tox.2006.08.006

Cited by 22 publications

(20 citation statements)

References 48 publications

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“…In the past, there was strong evidence that styrene-induced toxicity is related to oxidative stress (Harvilchuck et al, 2008(Harvilchuck et al, , 2009MeszkaJordan et al, 2009) and that this was likely due to the fact that styrene and styrene oxide produce significant decreases in liver and lung GSH levels (Turner et al, 2005;Carlson et al, 2006;Harvilchuck & Carlson, 2006). In the current studies styrene (600 mg/kg ip) markedly depleted GSH levels in both plasma and BALF within 3 h ( Table 1).…”

Section: Resultssupporting

confidence: 57%

“…Styrene has been shown in a number of studies to produce decreases in GSH levels in both liver and lung (Morgan et al 1993b;Gamer et al, 2004;Turner et al, 2005;Kaufmann et al, 2005;Carlson et al, 2006;Harvilchuck & Carlson, 2006). This may be related to its metabolism to GSH conjugates.…”

Section: Discussionmentioning

confidence: 99%

“…Since the toxicity of styrene is generally associated with its bioactivation to styrene oxide and the two enantiomers of styrene oxide differ in toxicity and their ability to deplete GSH (Gadberry et al, 1996;Carlson et al, 2006), it was of interest to determine whether there was a difference with respect to their abilities to alter GSH levels in plasma and BALF. R-Styrene oxide produced a significant decrease in both cases, whereas the S-styrene oxide exerted no marked effect (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…While these amounts are high in comparison to human exposures (Miller et al, 1994;Cohen et al, 2002), they have been used in previous studies by us (Gadberry et al, 1996;Carlson, 1997;Carlson et al, 2006;Harvilchuck et al, 2008;Meszka-Jordan et al, 2009) and others (Chakrabarti et al, 1993). Because of the limited solubility of styrene and styrene oxide in water, corn oil was used as the vehicle, and controls received an equivalent volume (1 ml/ 100 g).…”

Section: Experimental Designmentioning

confidence: 99%

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Depletion by Styrene of Glutathione in Plasma and Bronchioalveolar Lavage Fluid of Non-Swiss Albino (NSA) Mice

Carlson

2010

Journal of Toxicology and Environmental Health, Part A

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Styrene is a widely used chemical, but it is known to produce lung and liver damage in mice. This may be related to oxidative stress associated with the decrease in the levels of reduced glutathione (GSH) in the target tissues. The purpose of this study was to investigate the effect of styrene and its primary metabolites R-styrene oxide (R-SO) and S-styrene oxide (S-SO) on GSH levels in the lung lumen, as determined by amounts of GSH in bronchioalveolar lavage fluid (BALF) and in plasma. When non-Swiss albino (NSA) mice were administered styrene (600 mg/kg, ip), there was a significant fall in GSH levels in both BALF and plasma within 3 h. These returned to control levels by 12 h. The active metabolite R-SO (300 mg/kg, ip) also produced significant decreases in GSH in both BALF and plasma, but S-SO was without marked effect. Since GSH is a principal antioxidant in the lung epithelial lining fluid, this fall due to styrene may exert a significant influence on the ability of the lung to buffer oxidative damage.

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Section: Resultssupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

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Depletion by Styrene of Glutathione in Plasma and Bronchioalveolar Lavage Fluid of Non-Swiss Albino (NSA) Mice

Carlson

2010

Journal of Toxicology and Environmental Health, Part A

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“…To show its application the fabricated SPME fiber was used to determine styrene residue since it can adversely affect human health [28,29]. Cooked rice contained in polystyrene food package which is widely used in many food shops or supermarket was tested as real sample due to the possibility of the transferring of styrene monomer [30,31].…”

Section: Introductionmentioning

confidence: 99%