Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial

Park, Insung; Ochiai, Ryuji; Ogata, Hiroyasu; Kayaba, Momoko; Hari, Sayaka; Hibi, Masanobu; Katsuragi, Yoshihisa; Satoh, Makoto; Tokuyama, Kumpei

doi:10.1017/s0007114517000587

Cited by 48 publications

(44 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has already been reported that ELE has an appetite suppressing effect by inhibiting the parasympathetic nervous system, which controls the gastrointestinal tract [16]. On the other hand, chlorogenic acid, one of the major components of ELE, is known to potentiate parasympathetic nerves [21]. From these reports and our results, it can be assumed that the effect of ELE on the parasympathetic nervous system may be reversed between the active and inactive periods due to diurnal variation.…”

Section: Resultssupporting

confidence: 76%

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

Oikawa¹,

Miyazaki²,

Nishide³

et al. 2017

Glob Drugs Therap

View full text Add to dashboard Cite

IntroductionDu-zhong tea is a common drink ingested for health purposes. The tea is made by roasting the leaves of the Eucommia ulmoides tree. In recent years, the study of Eucommia leaf extract (ELE) has been focused on its efficacy in maintaining human health. Reports on the biogenic effectiveness of ELE ingestion have identified the following benefits: 1) antihyperlipidemic effects that reduce visceral fat and suppress elevated levels of triglyceride and cholesterol in the blood [1][2][3][4][5][6][7]; 2) effects on bone, such as preventing the onset of postmenopausal osteoporosis and promoting calcium accumulation in osteoblasts [8][9][10]; 3) antihypertensive effects that slowly decrease blood pressure by maintaining the flexibility of the blood vessels and promoting arterial smooth muscle relaxation [2,11]; 4) rapid eye movement sleep and non-rapid eye movement sleep inducing effect [12]; and 5) preventative effects on ulcerative colitis by asperuloside, one of the major components of ELE [13]. Thus, ELE promotes systemic health. Among the effects of ELE, many anti-obesity effects have been studied from the viewpoint of preventing lifestyle diseases. Therefore, we proposed that ELE ingestion might prevent the obesity caused by nocturnal eating, as ELE ingestion reduces food intake and water consumption during the light phase (i.e., inactive period) in rats [7,14,15]. On the other hand, it has been reported that appetite suppression due to the inhibition of the parasympathetic nervous system, which controls the gastrointestinal tract, is related to the suppression of feeding and the improvement AbstractEucommia leaf extract (ELE) is known to have a preventive effect on obesity. The effect of ELE partially depends on the inhibition of locomotor activity during inactive periods and indirect inhibition of food and water consumption. Moreover, it has been reported that suppression of the parasympathetic nervous system is involved in appetite suppression and that lipid metabolism is improved by ELE ingestion. However, there is no evidence that food and water consumption during the inactive period occur as a result of regulation of the parasympathetic nervous system. Therefore, in this study, the involvement of the parasympathetic nervous system was examined using water intake during the inactive period of rats as an index. Rats were fed a high-fat diet (35% fat; HFD) or an HFD + ELE 5% diet and were observed for 3 days during which pilocarpine (10 mg/kg/day, intraperitoneally; i.p.) or saline (i.p.; used as a control) was administered daily. When compared with the control group, no effect of pilocarpine was observed in the dark phase (active period) or light phases (inactive period). The slightly increased water consumption of the HFD + ELE 5% group was not affected by the administration of pilocarpine in the active period. However, the markedly decreased amount of water consumption in the inactive period that was due to ELE ingestion was restored to the control level by the administration of pilocarpine. These r...

show abstract

Section: Resultssupporting

confidence: 76%

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

Oikawa¹,

Miyazaki²,

Nishide³

et al. 2017

Glob Drugs Therap

View full text Add to dashboard Cite

show abstract

“…The results of the current study suggest that the quality of sleep in the second half of week 2 decreased due to the accumulation of psychological stress in daily work. In contrast, this decrease in sleep quality was suppressed in the active group in the second half of week 2, suggesting that CGAs consumed at a dose lower than that previously reported (Park et al., ) may be sufficient to improve sleep quality. Park et al.…”

Section: Discussioncontrasting

confidence: 60%

“…Park et al. reported that CGAs act in part by increasing parasympathetic nervous system activation (Park et al., ). Furthermore, acute psychological stress has been reported to decrease sleep quality and parasympathetic nerve activity during sleep (Hall et al., ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of chlorogenic acids on fatigue and sleep in healthy males: A randomized, double‐blind, placebo‐controlled, crossover study

Ochiai

Tomonobu

Ikushima

2018

Food Science & Nutrition

Self Cite

View full text Add to dashboard Cite

Chlorogenic acids (CGAs) are found in abundance in coffee beans and have numerous health benefits. This study investigated the effect of CGAs extracted from coffee beans on fatigue and sleep in healthy participants. This crossover study involved 16 men (aged 30–54 years) who were daytime workers with weekends off work. The participants were randomized into two groups: One group was given a placebo beverage, and the other was given an active beverage containing 300 mg of CGAs. The test beverages were consumed for 13 days starting on a Sunday. The evaluation criteria were feelings of fatigue and sleep quality, sleep‐related indices recorded by an activity meter, and biomarkers. Feelings of fatigue and sleep‐related indices during the first (first half of week 1) and second (second half of week 2) halves of the consumption periods were compared. Within the first half of week 1, no differences in feelings of fatigue were observed between the groups. However, during the second half of week 2, fatigue upon awakening and sleep quality in the active group were significantly improved compared with those in the placebo group. Sleep efficiency and total nocturnal awakening time were significantly deteriorated in the second half of week 2 compared with the first half of week 1 in the placebo group. Furthermore, significant differences in these indices were observed between the two groups in the second half of week 2. These results suggest that the daily consumption of CGA‐containing beverages may improve fatigue upon awakening and sleep quality.

show abstract

“…The methods employed to measure sleep outcomes varied across studies. Seven studies used subjective measures (i.e., diaries/logbooks and sleep questionnaires) [31][32][33][34][35][36][37], while one study used PSG/EEG [38,39], and five studies used a combination of PSG/EEG or actigraphy, and subjective measures [39][40][41][42][43].…”

Section: Dietary Supplementsmentioning

confidence: 99%

Effects of Diet on Sleep: A Narrative Review

et al. 2020

View full text Add to dashboard Cite

Many processes are involved in sleep regulation, including the ingestion of nutrients, suggesting a link between diet and sleep. Aside from studies investigating the effects of tryptophan, previous research on sleep and diet has primarily focused on the effects of sleep deprivation or sleep restriction on diet. Furthermore, previous reviews have included subjects with clinically diagnosed sleep-related disorders. The current narrative review aimed to clarify findings on sleep-promoting foods and outline the effects of diet on sleep in otherwise healthy adults. A search was undertaken in August 2019 from the Cochrane, MEDLINE (PubMed), and CINAHL databases using the population, intervention, control, outcome (PICO) method. Eligible studies were classified based on emerging themes and reviewed using narrative synthesis. Four themes emerged: tryptophan consumption and tryptophan depletion, dietary supplements, food items, and macronutrients. High carbohydrate diets, and foods containing tryptophan, melatonin, and phytonutrients (e.g., cherries), were linked to improved sleep outcomes. The authors posit that these effects may be due in part to dietary influences on serotonin and melatonin activity.

show abstract

Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: a randomised, placebo-controlled, double-blinded cross-over trial

Cited by 48 publications

References 45 publications

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

Effect of Eucommia leaf extract on water consumption in rats is mediated by the parasympathetic nervous system

Effect of chlorogenic acids on fatigue and sleep in healthy males: A randomized, double‐blind, placebo‐controlled, crossover study

Effects of Diet on Sleep: A Narrative Review

Contact Info

Product

Resources

About