Effects of subchronic exposure manganese oxide nanoparticles on the central nervous system, lipid peroxidation and antioxidant enzymes in rats

Зайцева, Н. В.; Zemlyanova, M.A.; Zvezdin, V.N.; Akafyeva, Т.I.; Mazunina, D.L.; Dovbish, А.А.

doi:10.21668/health.risk/2014.4.09.eng

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Introduction of manganese to an organism may induce pathologic changes both in internals and in the skin cover [38]. The earlier studies [39,40] showed that manganese oxide nanoparticles can enter the brain owing to their high permeability, be accumulated in the cells and cause functional impairment in the brain departments. In addition, it was established that the fatal dose (LD50) upon a single probe-feeding injection of an aqueous suspension of nanodispersed manganese oxide (15-29 nm in particle size) is 2340.0±602.6 mg kg −1 of body mass for BALB/C mice and 2577.0±669.6 mg kg −1 for Wistar rats.…”

Section: In Vivo Oncolytic Activity Of Np Mno Against Sw620 Xenograft...mentioning

confidence: 99%

Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells

Разумов¹,

Troitskii²,

Solovieva³

et al. 2022

Adv. Nat. Sci: Nanosci. Nanotechnol.

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A promising area of oncotherapy is the use of nanomaterials for diagnostics and imaging, as well as for delivering drugs and direct effect agents to tumour cells. We used earlier manganese oxide nanoparticles (NP MnO) as magnetic resonance imaging agents for visualisation and suppression of in vitro and in vivo growth of human glioblastoma cells. The present study was to demonstrate the selective antitumor effect of NP MnO against human tumour cells of different tissue origins, in particular, cells SW620, human colorectal adenocarcinoma. It was shown that NP MnO can inhibit selectively in vitro growth of SW620 cells; the index of selective cytotoxicity against human colorectal adenocarcinoma cells was 20. The range of optimal NP MnO doses was determined using subcutaneous introduction of the nanoparticles to SCID mice; the doses no more than 0.96 mgMn kg−1 had practically no local toxic effect in the animals. The subcutaneous administration of NP MnO in the specified dose range inhibited the growth of SW620 xenografts in SCID mice and led to an increase in their life expectancy. With administered NP MnO in doses of 0.32 and 0.96 mgMn kg−1, the index of inhibition of tumour growth for 21 days from the beginning of the introduction of nanoparticles was 43.0% and 69.8%, respectively. NP MnO seem promising for developing nanotheranostics agents for the visualisation and treatment of human tumours of different tissue origins.

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Section: In Vivo Oncolytic Activity Of Np Mno Against Sw620 Xenograft...mentioning

confidence: 99%

Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells

Разумов¹,

Troitskii²,

Solovieva³

et al. 2022

Adv. Nat. Sci: Nanosci. Nanotechnol.

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“…But when a dose was equal to 5 mg/kg of body weight a day, morphologic picture of brain and cerebellum tissues corresponded to that of control group; structure patterns were preserved in all the sections (Figure 14). [41]. [41].…”

Section: Studying Subchronic and Chronic Toxicity Of Nanodisperse Manmentioning

confidence: 99%

“…There are dilated perivascular and pericellular spaces in brain cortex layers. Painted with hematoxylin and eosin, magnification ×400[41].…”

mentioning

confidence: 99%

Toxicologic Characteristics of Nanodisperse Manganese Oxide: Physical-Chemical Properties, Biological Accumulation, and Morphological-Functional Properties at Various Exposure Types

Зайцева¹,

Zemlyanova²

2020

Heavy Metal Toxicity in Public Health

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Nanosized manganese oxide has excellent prospects. Some data imply that its particles can be toxic when introduced in various ways, and it requires further examination of this nanomaterial. The authors conducted research of nanodisperse MnO 2 water suspension at intragastric, inhalation, and skin-resorptive introduction into small rodents and obtained profound characteristics of its toxic effects, determined target organs and revealed dose-dependent effects. The substance was characterized with acute toxicity, and its bioaccumulation under long-term exposure caused morphofunctional disorders in brain, lipid peroxidation activation, and lower antioxidant system activity. The authors detected vessel hyperemia, subarachnoid hemorrhages, brain edema with perivascular and pericellular spaces dilatation, nerve fiber demyelinization, and focal dystrophic changes in vessels endothelium. After a long-term introduction in doses from 0.25 to 2.5 mg/kg, oxidizing-antioxidant imbalance occurred, neurotransmitters and electrolytes balance was violated, and there was also brush border epithelium insufficiency. Nanodisperse MnO 2 water suspension in doses equal to 2.5 and 0.25 mg/kg at intragastric introduction into Wistar rats did not have embryotoxic or teratogenic effects. It did not have any mutagenic effects in doses equal to 10.3 and 5.15 mg/kg or gonadotoxic effects either when introduced into Wistar male rats in doses equal to 10.3-5.15 mg/kg via gastric tube.

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Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells

et al. 2017

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Toxicity of different types of manganese nanoparticles against glioblastoma U-87MG and U-251 cells and normal human cells was studied using MTT test. The selectivity of the toxic effect of nanoparticles was evaluated as the ratio of 50% cytotoxic concentration (СС) for human embryos fibroblasts (FECh-15) to their СС for tumor cells. Five of 6 samples of tested nanoparticles demonstrated selective toxic effect in vitro. Manganese oxide nanoparticles were characterized by maximum selectivity (СС 6.9 nM and 2.1 nM for U-87MG and U-251 cells, respectively): selectivity index for glioblastoma U-87MG and U-251 cells was 29 and 95.2, respectively. Manganese oxide nanoparticles used for MRI detection of gliomas can be used for designing an oncolytic agent for the treatment of glial tumors in humans.

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Effects of subchronic exposure manganese oxide nanoparticles on the central nervous system, lipid peroxidation and antioxidant enzymes in rats

Cited by 4 publications

References 12 publications

Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells

Manganese oxide nanoparticles inhibit selectively the in vitro and in vivo growth of human colorectal SW620 adenocarcinoma cells

Toxicologic Characteristics of Nanodisperse Manganese Oxide: Physical-Chemical Properties, Biological Accumulation, and Morphological-Functional Properties at Various Exposure Types

Selective Cytotoxicity of Manganese Nanoparticles against Human Glioblastoma Cells

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