Effects of Subchronic Exposure to Cadmium and Diazinon on Testis and Epididymis in Rats

Abstract

The present study aimed to elucidate the structural changes in testis and epididymis of adult rats following subchronic peroral administration of cadmium at 30 mg/L, diazinon at 40 mg/L, cadmium at 30 mg/L, and diazinon at 40 mg/L, respectively. At the end of 90-day experiment, the samples of the testes and epididymis were assayed by qualitative and quantitative histological methods. The testis and epididymis weights increased following exposure to cadmium and simultaneous exposure to cadmium and diazinon. Testicular damage following cadmium and diazinon coexposure was significantly less expressive than in groups with individual administration of these compounds. Cadmium caused a significant thickening of seminiferous epithelium, cellular degeneration, and necrosis. Desquamation of immature germ cells resulted in a significant increase of intraepithelial spaces and reduced tubule volume in all experimental groups. Vascular dilation and congestion were detected in the interstitial tissue. The changes in epididymal histology in the group exposed to cadmium and group exposed simultaneously included a reduction of epithelium, necrotic epithelial cells, vasoconstriction, and interstitial edema together with mononuclear cell infiltration. Results did not indicate a synergistic or any additional effect from the simultaneous administration of both toxicants. Further research is needed to determine the significance and the mechanism of the adverse effects.

Effects of ethanol extract of <i>Bersama engleriana</i> leaves on oxidative stress and reproductive parameters in male Guinea pig (<i>Cavia porcellus</i>) exposed to cypermethrin

“…It is empirically used to treat many diseases such as malaria, headache, diabetes, typhoid, haemorrhoid etc. (Bosch, 2008;Lather et al, 2010). The study of Kuete et al (2008) showed that extracts from all parts (leaves, stem bark and roots) of this plant have antioxidant effects.…”

Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

“…Environmental pollutants such as pesticides and heavy metals are known to cause serious health effects through the induction of wide range of toxicological events and biochemical dysfunctions. Some earlier studies on combined exposure to pesticides and heavy metals have reported among others, immunotoxic, hematologic, and calcium homeostasis disruptive effects of these environmental contaminants [28,29]. There is however, a paucity of information on the use of natural agents in preventing or ameliorating these toxic effects.…”

Propolis alcohol extract attenuates prostate specific antigen disorders and prostate necrosis induced by the cadmium toxicity in rats

“…Prostate and testis are the target tissues and are highly sensitive to Cd. 25,26 Cd, at high dose, induces prostate epithelial cell damage associated with the irregular acini forms. Cd triggers a necrosis of stroma associated with the solid parenchyma areas.…”