Effects of subchronic lead intoxication of rats on the myocardium contractility

Protsenko, Yuri; Katsnelson, Boris A.; Klinova, Svetlana V.; Lookin, Oleg; Балакин, А. А.; Никитина, Л. В.; Gerzen, Oksana P.; Minigalieva, Ilzira A.; Privalova, Larisa I.; Gurvich, Vladimir B.; Sutunkova, Marina P.; Katsnelson, Leonid B.

doi:10.1016/j.fct.2018.07.034

Cited by 22 publications

(7 citation statements)

References 69 publications

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“…Turning back to the hematological features of lead intoxication, only some of the white blood indices revealed a noticeable, although statistically insignificant increase. These shifts are also noteworthy because they are fairly typical of experimental lead intoxications and, in some studies, were even more substantial than in the present one and statistically significant at that (e.g., [20][21][22][23][24]).…”

Section: Controlsupporting

confidence: 63%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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Outbred female rats were exposed to inhalation of lead oxide nanoparticle aerosol produced right then and there at a concentration of 1.30 ± 0.10 mg/m3 during 5 days for 4 h a day in a nose-only setup. A control group of rats were sham-exposed in parallel under similar conditions. Even this short-time exposure of a relatively low level was associated with nanoparticles retention demonstrable by transmission electron microscopy in the lungs and the olfactory brain. Some impairments were found in the organism’s status in the exposed group, some of which might be considered lead-specific toxicological outcomes (in particular, increase in reticulocytes proportion, in δ-aminolevulinic acid (δ-ALA) urine excretion, and the arterial hypertension’s development).

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Section: Controlsupporting

confidence: 63%

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Sutunkova

Solovyeva

Chernyshov

et al. 2020

IJMS

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“…At the same time, it is particularly relevant to the study of cardiotoxicity mechanisms because it has been shown that under subchronic lead intoxication, the in vitro contractile activity of muscle preparations extracted from rat myocardium undergoes a number of essential changes. 25 Meantime, one of the possible hypotheses concerning the mechanisms of decreased cardiomyocyte contractility under different NP impacts might be decreased ATP levels due to mitochondrial damage and dysfunction. 26 As concerns the effects of NP exposure which might be considered really specific to cardiomyocytes, we sought to identify possible changes in 2 indices: mean cell size and frequency of Ca 2þ spikes.…”

Section: Cell Line Characterization In Vitro Exposure Technique and mentioning

confidence: 99%

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

et al. 2020

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Spherical nanoparticles (NPs) of cadmium and lead sulfides (diameter 37 ± 5 and 24 ± 4 nm, respectively) have been found to be cytotoxic for HL-1 cardiomyocytes as evidenced by decrease in adenosine triphosphate–dependent luminescence. Cadmium sulfide (CdS)-NPs were discovered to produce a much greater cytotoxic impact than lead sulphide (PbS)-NP. Given the same dose range, CdS-NP reduced the number of calcium spikes. A similar effect was observed for small doses of PbS-NP. In addition to cell hypertrophy under the impact of certain doses of CdS-NP and PbS-NP, doses causing cardiomyocyte size reduction were identified. For these 3 outcomes, we obtained both monotonic “dose–response” functions (well approximated by the hyperbolic function) and different variants of non-monotonic ones for which we found adequate mathematical expressions by modifying certain models of hormesis available in the literature. Data analysis using a response surface linear model with a cross-term provided new support to the previously established postulate that a diversity of types of joint action characteristic of one and the same pair of damaging agents is one of the important assertions of the general theory of combined toxicity.

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“…Inflammation, also a characteristic of lead intoxication, was confirmed by increased leukocytes and lymphocytes levels 20 . Elevated number of platelets and the thrombocrit observed correspond to lead poisoning 21 .…”

Section: Blood Functional Indices -Lead Intoxicationmentioning

confidence: 94%

Blood metabolic fingerprinting of rats, subjected to subchronic lead exposure

Chemezov¹,

Sutunkova²,

Minigalieva³

et al. 2021

Public Health Toxicol

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INTRODUCTION Environmental pollution with heavy metals is vital issue in the present time. Lead, as one of the environmental contaminators, deserves attention due to its applicability in human activity and its xenobiotic character. METHODS In this study we used an untargeted metabolomic approach -the metabolomic fingerprinting method. Lead acetate was intraperitoneally injected to rats within the framework of a subchronical experiment and blood samples were analyzed by UHPLC-MS. Metabolite expression was qualitatively compared between treated and control groups. For substances with a significant content difference, tandem CID spectra for structure elucidation were obtained using an exact mass search by generating a list of potential formulas, by a characteristic fragments database search, using in silico mass spectra prediction, and by looking for a specific fragmentation rearrangement. RESULTS Untargeted metabolomic analysis shows 37 metabolites with significant changes in expression in comparing the control and exposure group. Annotation

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Effects of subchronic lead intoxication of rats on the myocardium contractility

Cited by 22 publications

References 69 publications

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Manifestation of Systemic Toxicity in Rats after a Short-Time Inhalation of Lead Oxide Nanoparticles

Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations

Blood metabolic fingerprinting of rats, subjected to subchronic lead exposure

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