Objectives: In self reports, abstinent ecstasy/polydrug users claim that they experience certain ongoing affective and psychological changes including elevated anxiety, arousal and depression. In addition, various aspects of cognition (e.g. everyday memory, reasoning, executive functioning) appear to be affected. The present paper investigated the link between these two psychological sequelae. Methods: 95 ecstasy/polydrug users completed tests of reasoning, intelligence, information processing speed, executive functioning, and everyday memory. Affect was measured via a mood adjective checklist. Adverse effects attributed to ecstasy were measured via responses to adjectives reflecting changes in users since they started using the drug. In addition, indicators of sleep quality and daytime sleepiness were obtained.Results: Users attributed a number of adverse effects to ecstasy, namely heightened irritability, depression, paranoia and deteriorating health. Adverse effects were significantly and negatively correlated with aspects of intelligence, everyday memory and sleep quality. Length of use of ecstasy use was positively correlated with adverse effects. Conclusions: While many users attribute a number of adverse affects to their use of ecstasy it remains unclear whether these self perceptions are a corollary of the psychopharmacological effects of the drug or reflect factors which in fact predate its use.Keywords: ecstasy, mood, adverse effects, intelligence 3 The present research is concerned with those individuals who consume the street drug ecstasy, usually along with a range of other illicit substances. The main ingredient of ecstasy is 3, 4-methylenedioxymethamphetamine (MDMA). In a review of the literature, Parrott (2004) notes that since the late 1990s, in terms of psychoactive ingredients, chemical analysis reveals that most ecstasy tablets consisted of between 80-100% MDMA with the typical dose increasing during the first half of the present decade. Previous research from our laboratory has revealed that ecstasy/polydrug users are impaired on a range of cognitive measures compared to non-ecstasy using controls (Montgomery, Fisk, & Newcombe, 2005a; Montgomery, Fisk, Newcombe, & Murphy, 2005b;Montgomery, Fisk, Newcombe, Wareing & Murphy, 2005c;. However, it has sometimes proved difficult to establish a link between indicators of the level of ecstasy use (e.g. measures of lifetime use) and cognitive outcomes. It is possible that different patterns of drug taking may be associated with different levels of risk. For example, it may be the case that those persons who take ecstasy while engaging in excessive physical activity for prolonged periods of time in hot environments without adequately monitoring fluid intake are at particular risk from ecstasy-related neurotoxicity, (Parrott, Rodgers, Buchanan, Ling, Heffernan, & Scholey, 2006).Alternatively it may be the number of tablets typically taken on each occasion of use (Thomasius, Petersen, Buchert, Andresen, Zapletalova, Wartberg, et al. 2003) whic...