Effects of subcutaneous verapamil on the duration of local anesthetic blockade

Laurito, Charles E.; Cohn, Stephan J.; Becker, Gerald L.

doi:10.1016/s0952-8180(05)80014-5

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…Choe et al [8], demonstrated that addition of verapamil to bupivacaine administered epidurally resulted in less post-operative analgesic requirement. Laurito et al [9], demonstrated that verapamil failed to prolong duration of lignocaine anaesthesia when given subcutaneously.…”

Section: Discussionmentioning

confidence: 99%

Verapamil as an Adjunct to Local Anaesthetic for Brachial Plexus Blocks

Lalla

Anant

Nanda³

2010

Medical Journal Armed Forces India

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Section: Discussionmentioning

confidence: 99%

Verapamil as an Adjunct to Local Anaesthetic for Brachial Plexus Blocks

Lalla

Anant

Nanda³

2010

Medical Journal Armed Forces India

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“…demonstrated that verapamil failed to prolong the duration of lignocaine anesthesia when given subcutaneously. [ 22 ] Del Pozo et al . found that subcutaneous verapamil failed to exhibit antinociceptive effects, but analgesic effect was seen when administered by intracerebroventricular route in rats.…”

Section: Discussionmentioning

confidence: 99%

Effect of verapamil as an adjuvant to levobupivacaine in supraclavicular brachial plexus block

et al. 2017

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Background:Many adjuvants have been used with local anesthetics to reduce the time of onset and prolong the duration of analgesia in brachial plexus blocks. However, few studies are there using verapamil as an adjuvant with levobupivacaine.Aims:This study aims to study the effects of verapamil as adjuvant to levobupivacaine in supraclavicular block for upper extremity surgery.Methods:In this double-blinded clinical trial, 60 American Society of Anesthesiologist Class I and II patients posted to undergo upper extremity surgery were divided into 2 different groups randomly. In Group A, the patients received 30 ml levobupivacaine 0.5% plus 2 ml normal saline and Group B patients received 30 ml levobupivacaine 0.5% plus 5 mg verapamil diluted to 2 ml normal saline for supraclavicular block. Time of request for rescue analgesia, onset and duration of sensory motor blocks and changes in hemodynamic parameters were studied and analyzed. P < 0.001 was considered statistically significant.Results:Time for a request for rescue analgesia was 425.80 ± 90.46 min in Group B and 366.13 ± 70.42 min in Group A which was clinically significant. The mean of sensory and motor block onset time in Group B was less than in Group A, the difference between the two groups being statistically significant (P < 0.001). In Group A, mean duration of sensory block was 316.13 ± 91.08 min and in Group B was 375.83 ± 114.48 min, which was statistically significant (P < 0.001).Conclusion:The addition of verapamil as an adjuvant to levobupivacaine in brachial plexus blockade delayed the requirement of rescue analgesia with decreased onset time and prolonged duration of sensory and motor block characteristics.

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“…Intramuscular administration of propranolol in masseter muscle of volonteers reduced the pain caused by intramuscular injection of serotonin, as shown in the study of Ernberg et al 17 . On the other hand, Charles et al 18 showed that subcutaneous coadministration of verapamil and lidocaine shortened duration of local anesthesia in comparison to the lidocaine only. Propranolol demonstrates local anesthetic effect comparable to that of lidocaine by decreasing sodium and calcium influx 19 .…”

Section: Discussionmentioning

confidence: 99%

“…Although in our study the anesthetized area was not different among the groups, local anesthesia started earlier, dissipated more rapidly and lasted shorter in the patients with chronic cardiovascular therapy. In the study of Charles and associates 18 about the subcutaneous application of verapamil and lidocaine on volar forearm compared to lidocaine itself it was shown that duration of action of anesthesia was shorter after coadministration of the two drugs. This result could have been caused by vasodilating effect of verapamil causing local erythema and/or edema, physicochemical reactions with lidocaine, or both; both actions can decrease bioavailability of lidocaine 18 .…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Charles and associates 18 about the subcutaneous application of verapamil and lidocaine on volar forearm compared to lidocaine itself it was shown that duration of action of anesthesia was shorter after coadministration of the two drugs. This result could have been caused by vasodilating effect of verapamil causing local erythema and/or edema, physicochemical reactions with lidocaine, or both; both actions can decrease bioavailability of lidocaine 18 . Like in this study, systemically administered anti-hypertensive drugs with universal vasodilating properties in our study caused significantly shorter duration of anesthesia in groups of patients who were on chronic cardiovascular therapy.…”

Section: Discussionmentioning

confidence: 99%

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The impact of cardiovascular drugs on the efficacy of local anesthesia in dentistry

Milosavljević¹,

Janković²

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background and Aim. Drugs used chronically by patients with diseases of the cardiovascular system (group C of the ATC classification) may act on adrenergic receptors and/or certain ion channels, which gives them the potential to interact with the action of local dental anesthetics. The aim of the study was to investigate the effect of systemically administered chronic cardiovascular medication (oral route) on the efficacy of intraoral local anesthesia in patients with diseases of the cardiovascular system. Patients and Methods. This was a prospective cohort study which analyzed the efficacy of local terminal anesthesia (onset of anesthesia, duration anesthetized area) in the upper jaw of 70 patients: 40 patients on medication for cardiovascular system disorders and 30 patients who were not using these drugs (the control group). The following cardiovascular drugs were used: beta blockers, angiotensin converting enzyme inhibitors, calcium channel blockers, vasodilatators, diuretics, angiotensin receptor blockers, antiarrhythmics, statins and alfa blockers. Results. The onset of anesthesia on the vestibular side was faster in those taking cardiovascular drugs (40.50±19.87 s) than the control patients (58.93±31.07 s; P = 0.004) and duration of anesthesia on this side was shorter. Although the difference was not significant, it was evident that on vestibular and palatal side the anesthetized area was more rapidly reduced in the patients taking cardiovascular drugs. The duration of cardiovascular therapy also had a significant impact on the anesthetized area. Conclusion. Drugs acting on cardiovascular system may influence the effect of local anesthetics used in dentistry, possibly through interaction with autonomic receptors and ion channels.

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Effects of subcutaneous verapamil on the duration of local anesthetic blockade

Cited by 7 publications

References 2 publications

Verapamil as an Adjunct to Local Anaesthetic for Brachial Plexus Blocks

Verapamil as an Adjunct to Local Anaesthetic for Brachial Plexus Blocks

Effect of verapamil as an adjuvant to levobupivacaine in supraclavicular brachial plexus block

The impact of cardiovascular drugs on the efficacy of local anesthesia in dentistry

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