Effects of submucosally administered platelet-rich plasma on the rate of tooth movement:

Abstract

Objectives To evaluate the effects of submucosally administered platelet-rich plasma (PRP) on the rate of maxillary canine retraction. Levels of soluble receptor activator of nuclear factor-κb ligand (sRANKL) and osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) were also measured over 2 months. Materials and Methods This split-mouth trial involved 20 sites in 10 subjects randomly assigned to PRP (experimental) side and control side. After alignment, the freshly prepared PRP was injected submucosally distal to the experimental side maxillary canine, and retraction was performed using NiTi closed-coil springs (150 g) on 0.019 × 0.025-inch stainless steel wire. The rate of canine movement was assessed using digital model superimposition at 0, 30, and 60 days. The OPG and sRANKL were assayed using enzyme-linked immunosorbent assay from GCF collected at 0, 1, 7, 21, 30, and 60 days. Results Twenty sites were analyzed using paired t test. The rate of tooth movement increased significantly by 35% on the PRP side compared with the control side in the first month (P = .0001) and by 14% at the end of the second month (P = .015). Using the Mann–Whitney U test, OPG levels were found to be significantly decreased on the 7th (P = .003) and 30th day on the PRP side (P = .01), while sRANKL became detectable by the third week postinjection on the PRP side (P = .069). Conclusions Submucosal injection of platelet-rich plasma significantly increased tooth movement during the 60-day observation period. Local injection of PRP significantly altered the levels of OPG and sRANKL in GCF.

The effect of platelet-rich concentrates on orthodontic tooth movement: A review of randomized controlled trials

“…Then, 36 articles remained after screening the titles and abstracts. 27 studies were excluded with reasons (Supplementary Table 2) and 9 were included in the systematic review ( Figure 1 ) [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].

Figure 1 PRISMA flow-chart diagram of literature selection.

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“…A total of 158 patients were examined, with mean age ranging from 16.45 22 to 33 years [ 21 ]. Among 9 RCTs included, 8 adopted split-mouth design [ 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 ]. 3 studies tested PRP [ 20 , 26 , 27 ], and the other 6 investigated PRF, of which 1 applied PRF clot [ 19 ], 1 applied PRF membrane [ 21 ], and 4 applied PRF injection [ 22 , 23 , 24 , 25 ].…”

“…Among 9 RCTs included, 8 adopted split-mouth design [ 19 , 20 , 21 , 22 , 23 , 25 , 26 , 27 ]. 3 studies tested PRP [ 20 , 26 , 27 ], and the other 6 investigated PRF, of which 1 applied PRF clot [ 19 ], 1 applied PRF membrane [ 21 ], and 4 applied PRF injection [ 22 , 23 , 24 , 25 ]. The OTM rate was measured by space closure in 1 study [ 19 ], incisor retraction in 1 study [ 24 ] and canine distalization in another 7 studies [ 20 , 21 , 22 , 23 , 25 , 26 , 27 ], with periods lasting from 4 weeks [ 24 ] to 1.5 years [ 26 ].…”

“… PRP injection Canine distalization: distance between mandibular canine cusp tip and first molar central fossa evaluated using digital Vernier caliper. 9 Angel 2022 [ 27 ] India Split-mouth design 10 patients, 6 females, 4 males. Age: 19.05 ± 3.3 years, range 16–24 years.…”

“… PRP injection accelerated OTM rate by 1.24 times. Moderate 9 Angel 2022 [ 27 ] T0: before canine retraction. T2-T3: 30 or 60 days.…”