Effects of substance P during the recovery of hearing function after noise-induced hearing loss

Kanagawa, Eiju; Sugahara, Kazuma; Hirose, Yoshio; Mikuriya, Takefumi; Shimogori, Hiroaki; Yamashita, Hiroshi

doi:10.1016/j.brainres.2014.07.024

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Somatosensory nociceptors can become sensitized and release CGRP-α and substance P after tissue damage ( Andrew and Greenspan, 1999 ; Li et al, 2008 ; Smith et al, 2013 ; Murthy et al, 2018 ). Previous studies have shown an effect of substance P directly on SGNs and a protective effect of substance P after acoustic trauma ( Nario et al, 1995 ; Ito et al, 2002 ; Sun et al, 2004 ; Kanagawa et al, 2014 ). Therefore, additional study of the effect of substance P on type II afferents in the context of acute damage is needed.…”

Section: Discussionmentioning

confidence: 96%

Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea

Nowak

Wood

Glowatzki

et al. 2021

eNeuro

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Auditory stimuli travel from the cochlea to the brainstem through type I and type II cochlear afferents. While type I afferents convey information about the frequency, intensity, and timing of sounds, the role of type II afferents remains unresolved. Limited recordings of type II afferents from cochlear apex of pre-hearing rats reveal they are activated by widespread outer hair cell stimulation, ATP, and by the rupture of nearby outer hair cells. Altogether, these lines of evidence suggest that type II afferents sense loud, potentially damaging levels of sound. To explore this hypothesis further, calcium imaging was used to determine the impact of acoustic trauma on the activity of type II cochlear afferents of young adult mice of both sexes. Two known marker genes (Th, Drd2) and one new marker gene (Tac1), expressed in type II afferents and some other cochlear cell types, drove GCaMP6f expression to reveal calcium transients in response to focal damage in the organ of Corti in all turns of the cochlea. Mature type II afferents responded to acute photoablation damage less often but at greater length compared to pre-hearing neurons. In addition, days after acoustic trauma, acute photoablation triggered a novel response pattern in type II afferents and surrounding epithelial cells, delayed bursts of activity occurring minutes after the initial response subsided. Overall, calcium imaging can report type II afferent responses to damage even in mature and noise-exposed animals and reveals previously unknown tissue hyperactivity subsequent to acoustic trauma.

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Section: Discussionmentioning

confidence: 96%

Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea

Nowak

Wood

Glowatzki

et al. 2021

eNeuro

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“…Это обусловлено преимущественно особенностями ее слухового восприя тия, включающего частотный диапазон человека [10]. В литературе широко представлены акустические стиму лы, применяемые при создании моделей акустической травмы с использованием этих животных, которые отли чаются по спектру, интенсивности и продолжительно сти [11][12][13][14][15]. Изучается и вопрос применения комбиниро ванного (шумо-вибрационного) воздействия [16].…”

Section: Introductionunclassified

Evaluation of the impact of a special sound signal on the functional state of the hearing organ (experimental study)

Dvoryanchikov

Kuznetsov

Logatkin³

et al. 2022

Medicinskij sovet

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Introduction. The integration of special acoustic means into the safety system makes it relevant to conduct biomedical research to evaluate the impact of their effects on the hearing organs. Objective. To study the characteristics of a special sound signal and its effect on the hearing organ of an experimental biological model. Materials and methods. The study was conducted on 6 males (12 ears) guinea pigs (Cavia porcellus) weighing 200–250 grams at the age of 4 weeks. A set of special audio equipment was used to generate an acoustic signal. The study was conducted in a room with an area of about 47 m2. The time of a single exposure to experimental animals was 3 minutes at a sound level of 127–128 dBA. Before exposure and at different times after exposure (after 24 and 72 hours), the otoscopic picture was evaluated, a Preyer’s reflex and distortion-product otoacoustic emissions (DPOAEs) was carried out. Results. The special sound signal was characterized by distinct frequency components and can be attributed to tonal noises. After acoustic exposure to a special sound signal, a normal otoscopic picture was observed in experimental animals. Restoration of the Preyer’s reflex occurred 24 hours after exposure. The restoration of the DPOAEs to background values at frequencies from 1.5 to 3.3 kHz occurred 24 hours after acoustic exposure, at a frequency of 4.2 kHz there was a significant tendency to recovery. Conclusions. With a short-term (within three minutes) single exposure to a special sound signal with a sound level of 127 to 128 dBA on biological models (guinea pigs), no pathology of the hearing organ was detected. Given the greater resistance of humans to acoustic effects, compared to guinea pigs, this can equally be extended to humans.

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“…Due to importance of palm oil industry in Malaysia, any hazard that poses a threat to the health of organization cannot be underestimated. A significantly high number of researches had investigated on the potential of noise-induced hearing loss in terms of auditory effects [1], [2], [3], [4], [5], [6]. However, there is a lake of attention is being paid to the non-auditory effects of noise.…”

Section: Introductionmentioning

confidence: 99%

Environmental Noise and the Association with Occupational Stress among Palm Oil Mill Workers

Naeini¹,

Tamrin²,

Hashim³

et al. 2015

IJSER

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ABSTRACT:In palm oil mills the environmental sound level, resulting from operating machineries, is usually exceeding the action level of noise (85dB(A)). Whereas the excessive noise can develop chronic job stress, thus this study aims to determine the relationship between personal noise exposure and occupational stress among palm oil mill workers. A cross sectional study was done among 173 workers at five selected mills namely in Perak, Selangor and Negeri Sembilan. Environmental noise and personal noise exposure measured using Sound Level Meter (Model: Lutron SL-4112) and Dosimeter (Model: wireless110A) respectively. Alpha-amylase activity was used to determine the non-auditory effects of noise through determining the stress level. Results showed that, 100% of the workers among exposed group (PNE≥85 dB (A)) experiencing stress condition while 43% of non-exposed group (PNE<85dB (A)) experiencing stress condition. Statistically alpha amylase activity in stimulated condition among exposed group was significantly higher than non-exposed group (t-value=-3.983, p-value=0.000). As the conclusion, there is a significant relationship between alpha amylase activity and personal noise exposure among palm oil mill workers. (rs=0.725, p-value=0.000)

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Effects of substance P during the recovery of hearing function after noise-induced hearing loss

Cited by 5 publications

References 44 publications

Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea

Prior Acoustic Trauma Alters Type II Afferent Activity in the Mouse Cochlea

Evaluation of the impact of a special sound signal on the functional state of the hearing organ (experimental study)

Environmental Noise and the Association with Occupational Stress among Palm Oil Mill Workers

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