Effects of sucromalt on postprandial responses in human subjects

Abstract

Backgroud/Objective: To compare postprandial responses elicited by sucromalt, a nutritive sweetener produced by treating a blend of sucrose and corn syrup with an enzyme from Leuconostoc mesenteroides, with those after 42% of high-fructose corn syrup (HFCS), and to see if the reduced responses after sucromalt could be accounted for by carbohydrate malabsorption. Subject and Methods: Three experiments were performed in separate groups of normal subjects studied after overnight fasts using double-blind, randomized, cross-over designs. HFCS was used as the control because it contained a similar amount of fructose as sucromalt. Experiment 1 (n ¼ 10): plasma glucose and insulin were measured after 50 g sucromalt and 50 g HFCS. Experiment 2 (n ¼ 10): metabolic profiles were measured after 80 g HFCS, 80 g sucromalt or 56 g fructose/glucose blend plus 24 g inulin. Experiment 3 (n ¼ 20): the glycaemic indices of sucromalt and HFCS were determined. Results: Mean glucose and insulin responses after sucromalt were 66 and 62%, respectively, of those after HFCS (Po0.05). The inulin treatment, used to mimic the effects of carbohydrate malabsorption, elicited higher breath hydrogen (H 2 ), lower glucose and insulin responses, and a significantly earlier rise in serum free fatty acids (FFA) than those of HFCS (all Po0.05). Sucromalt elicited no rise in breath H 2 , and delayed falls in glucose and insulin, and a delayed rebound of FFA compared to HFCS (all Po0.05). Conclusions:The reduced glucose and insulin responses elicited by sucromalt are not explained by malabsorption and are more likely related to differences in either rate of digestion and absorption or postabsorptive handling by body.

Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models

“…These substances contained primarily a-(1,3) and a-(1,6) linkages. These findings are consistent with previous reports on Sucromalt, which is composed of similar linkages and is hydrolysed to glucose in in vitro and human models (Grysman et al 2008;Lee et al 2016).…”

“…With regard to the substances that were used as highly digestible controls in the in vitro and animal experiments, maltodextrin is formed from units of glucose with a-(1,4) bonds (Eliasson 2006), whereas PSF (purified Sucromalt fraction) has an average DP of 10 and comprises glucoses that are linked by alternating a-(1,3) and a-(1,6) linkages, except for the terminal glucose molecules, which are joined by an a-(1,4) bond (Grysman et al 2008;Lee et al 2016). PDX, the low-digestible control, has an average DP of 12, a molecular weight of approximately 2 Â 10 3 g/mol, and all various combinations of aand b-linked (1,2), (1,3), (1,4) and (1,6) glycosidic linkages, of which (1,6) linkages predominate (Lahtinen et al 2010), but it is not easily digested due to its highly branched polymeric structure (Craig et al 1998).…”

Índice glicémico, carga glicémica e insulina posprandial a dos fórmulas isoglucídicas con distintos edulcorantes y fibra en adultos sanos y diabéticos tipo 2

“…Los carbohidratos digeridos lentamente pueden viajar más abajo en el intestino delgado antes de ser absorbidos y estimular un incremento plasmático tardío del GLP-1 (25). Tal es el caso de la sucromaltosa (análogo natural de la sacarosa, de menor impacto glucémico) (18,25), con incremento sostenido del GLP-1 durante cuatro horas postingesta de 50/80 g, lo que confirma su lenta absorción (25). Esto sugiere que la cantidad/calidad de los CHO podría mejorar la función de las células beta del DM2 en tiempo prolongado (2).…”

Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract

“…It has also been reported that alternan oligosaccharides derived from alternanase activity are used as low-glycemic sweeteners. Some studies state that these oligosaccharides are potential prebiotics (Leathers, Hayman, and Côt e 1997), however in vivo trials in humans showed that they are slowly but fully digestible by human digestive enzymes in the gastrointestinal track (2008, Grysman, Carlson, andWolever 2008;Vanschoonbeek et al 2009). A recent study on a-glucan oligomers containing (a1!6) and (a1!3) linkages with DP ranging from 3-12, showed similar glucose and insulin response curves as the dextrose control in humans.…”